Cell Cycle and Cell Differentiation

1. Front Matter

   Pages I-XI

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2. Myogenesis: A Cell Lineage Interpretation

   • S. R. Dienstman, H. Holtzer

   Pages 1-25

3. The Organization of Red Cell Differentiation

   • Harold Weintraub

   Pages 27-42

4. The Cell Cycle, Cell Lineage, and Neuronal Specificity

   • R. K. Hunt

   Pages 43-62

5. Neurogenesis and the Cell Cycle

   • Creighton H. Phelps, S. E. Pfeiffer

   Pages 63-83

6. The Cell Cycle and Cell Differentiation in the Drosophila Ovary

   • Robert C. King

   Pages 85-109

7. The Cell Cycle and Cellular Differentiation in Insects

   • Peter Lawrence

   Pages 111-121

8. Nuclear Transplantation and the Cyclic Reprogramming of Gene Expression

   • J. B. Gurdon

   Pages 123-131

9. Morphogenesis during the Cell Cycle of the Prokaryote, Caulobacter crescentus

   • Nancy B. Wood, Lucille Shapiro

   Pages 133-149

10. Cell Division and the Determination Phase of Cytodifferentiation in Plants

    • Frederick Meins Jr.

    Pages 151-175

11. The Cell Cycle and Tumorigenesis in Plants

    • Armin C. Braun

    Pages 177-196

12. Cell Cycle and Liver Function

    • R. Tsanev

    Pages 197-248

13. Histones, Differentiation, and the Cell Cycle

    • Thaddeus W. Borun

    Pages 249-290

14. Cell Changes in Neurospora

    • R. E. Nelson, C. P. Selitrennikoff, R. W. Siegel

    Pages 291-310

15. Back Matter

    Pages 311-334

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It is instructive to compare the response of biologists to the two themes that comprise the title of this volume. The concept of the cell cycle-in contra­ distinction to cell division-is a relatively recent one. Nevertheless biologists of all persuasions appreciate and readily agree on the central problems in this area. Issues ranging from mechanisms that initiate and integrate the synthesis of chro­ mosomal proteins and DNA during S-phase of mitosis to the manner in which assembly of microtubules and their interactions lead to the segregation of metaphase chromosomes are readily followed by botanists and zoologists, as well as by cell and molecular biologists. These problems are crisp and well-defined. The current state of "cell differentiation" stands in sharp contrast. This, one of the oldest problems in experimental biology, almost defies definition today. The difficulties arise not only from a lack of pertinent information on the regulatory mechanisms, but also from conflicting basic concepts in this field. One of the ways in which this situation might be improved would be to find a broader experimental basis, including a better understanding of the relationship between the cell cycle and cell differentiation.

• DNA
• Zelldifferenzierung
• biology
• cell
• cell cycle
• cell differentiation
• cell division
• chromosome
• proteins

• Department of Anatomy, University of Pennsylvania, Philadelphia, USA

  Howard Holtzer

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