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Chiral N-Heterocyclic Carbenes as Stereodirecting Ligands in Asymmetric Catalysis

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N-Heterocyclic Carbenes in Transition Metal Catalysis

Part of the book series: Topics in Organometallic Chemistry ((TOPORGAN,volume 21))

Abstract

After the first attempts to use chiral NHC ligands in asymmetric catalysis in the late 1990s, which initially met with only limited success, several novel structural concepts have emerged since the beginning of this decade that have led, literally, to an explosion in the field. With a significant number of highly selective chiral catalysts based on chiral NHCs having been reported very recently, several general trends in the design of new NHC-containing molecular catalysts for stereo-selective transformations in organic synthesis have emerged. This development is the focus of this review.

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Authors and Affiliations

  1. Anorganisch-Chemisches Institut, Universität Heidelberg, Im Neuenheimer Feld 270, 69120, Heidelberg, Germany

    Lutz H. Gade

  2. Laboratoire de Chimie Organométallique et de Catalyse, Institut Le Bel, Université Louis Pasteur, 4 rue Blaise Pascal, 67000, Strasbourg, France

    Stéphane Bellemin-Laponnaz

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  1. Lutz H. Gade
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  2. Stéphane Bellemin-Laponnaz
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Correspondence to Lutz H. Gade .

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Gade, L.H., Bellemin-Laponnaz, S. (2006). Chiral N-Heterocyclic Carbenes as Stereodirecting Ligands in Asymmetric Catalysis. In: N-Heterocyclic Carbenes in Transition Metal Catalysis. Topics in Organometallic Chemistry, vol 21. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-36930-1_5

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