Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of NO-synthase. It is generated during proteolysis of methylated proteins. ADMA is removed either by renal excretion or metabolic degradation by the enzyme dimethylarginine dimethylaminohydrolase. ADMA can be produced and degraded by several cell types including human endothelial and tubular cells. Elevated ADMA concentrations in the blood are found in a number of chronic diseases associated with endothelial dysfunction such as hypercholesterolemia, hypertension, arteriosclerosis, chronic renal failure, and chronic heart failure.
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© 2012 Springer-Verlag Berlin Heidelberg
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(2012). ADMA. In: Mooren, F.C. (eds) Encyclopedia of Exercise Medicine in Health and Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-29807-6_14425
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DOI: https://doi.org/10.1007/978-3-540-29807-6_14425
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