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NGF, Regulation during Inflammation

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Encyclopedia of Pain

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Definition

In inflamed tissue, there is increased expression of nerve growth factor (NGF), which affects afferent neuron function, and contributes to the development and resolution of the inflammatory process. Pharmacological tools that can modify inflammation-induced NGF biosynthesis are, therefore, of potential therapeutic value.

Characteristics

Nerve growth factor (NGF) belongs to a family of structurally related neurotrophins. During inflammation, there is a rapid increase in local NGF biosynthesis. The local increase in NGF in inflamed tissues leads to changes in the phenotype of a subset of primary afferent neurons, with consequences for the transmission of noxious afferent input (Mendell et al. 1999).

In addition to its neurotrophic properties, NGF has been shown to affect immune cell function (Aloe et al. 1999). Direct neuronal effects (Mendell et al. 1999), as well as effects on immune cells (Bennett et al. 1998; Schuligoi 1998), seem to contribute to NGF-induced sensitization...

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References

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Author information

Authors and Affiliations

  1. Medical University Graz, Graz, Austria

    Rainer Amann

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  1. Rainer Amann
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Editor information

Editors and Affiliations

  1. Physiological Institute, University of Würzburg, Würzburg, Germany

    Robert F. Schmidt

  2. Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas, USA

    William D. Willis

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© 2007 Springer-Verlag Berlin Heidelberg

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Amann, R. (2007). NGF, Regulation during Inflammation. In: Schmidt, R., Willis, W. (eds) Encyclopedia of Pain. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-29805-2_2720

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  • DOI: https://doi.org/10.1007/978-3-540-29805-2_2720

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-43957-8

  • Online ISBN: 978-3-540-29805-2

  • eBook Packages: MedicineReference Module Medicine

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