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Neurogenic Inflammation, Vascular Regulation

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Encyclopedia of Pain

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Definition

Neuropeptides, such as neurokinins (substance P, neurokinin A) and CGRP, are the mediators of neurogenic inflammation. Their primary targets are blood vessels within the microvasculature where they elicit vasodilation and, by increasing the leakiness of the blood-tissue-barrier, plasma extravasation. Neurokinin effects may, in part, be mediated indirectly by the activation of mast cells and endothelial cells. At the neurovascular junction, neurokinins and CGRP interact with sympathetic neurotransmitters, vasoactive hormones and autacoids produced by the endothelium that are involved in the on-going regulation of the vasculature.

Characteristics

Vascular Effects of Neurokinins and CGRP

Both neurokinins and CGRP act primarily on blood vessels, but their efficacy in evoking vasodilation and plasma extravasation is different. The neurokinins substance P and neurokinin A are the main mediators of neurogenic plasma extravasation. They act on neurokinin 1 (NK1) receptors on...

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Authors and Affiliations

  1. FH Bonn-Rhein-Sieg, Rheinbach, Germany

    Heinz-Joachim Häbler

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  1. Heinz-Joachim Häbler
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Editor information

Editors and Affiliations

  1. Physiological Institute, University of Würzburg, Würzburg, Germany

    Robert F. Schmidt

  2. Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas, USA

    William D. Willis

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© 2007 Springer-Verlag Berlin Heidelberg

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Häbler, HJ. (2007). Neurogenic Inflammation, Vascular Regulation. In: Schmidt, R., Willis, W. (eds) Encyclopedia of Pain. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-29805-2_2645

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  • DOI: https://doi.org/10.1007/978-3-540-29805-2_2645

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-43957-8

  • Online ISBN: 978-3-540-29805-2

  • eBook Packages: MedicineReference Module Medicine

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