Thrombosis, Arterial and Fibrinogen

Cate, Hugo Ten

doi:10.1007/978-3-540-29676-8_633

Hugo Ten Cate²

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Synonyms

A alpha polypeptide; FGA

Definition and Characteristics

Fibrinogen is a 340 kD glycoprotein of three nonidentical polypeptides linked by disulfide bonds. The promoter regions from these genes contain hepatic nuclear factor 1 and interleukin-6 responsive elements. The latter may be responsible for most of the biological variation during acute phase reactions. Thrombin causes a limited proteolysis of fibrinogen releasing fibrinopeptides A and B from the N terminal regions of the alpha and beta chains respectively. Thrombin also activates factor XIII (fibrin-stabilizing factor), which enables cross linking of fibrin molecules into a polymerized fibrin meshwork.

Prevalence

Nine and five percent of fibrinogen variability is accountable to beta chain polymorphisms detected by BclI and HaeIII, respectively [1]. The –455 A allele is present in ~20% of the population and these individuals have ~10% higher fibrinogen levels compared to those with the GG genotype [2].

Genes

Evidence...

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References

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Kottke-Marchant K (2002) Genetic polymorphisms associated with venous and arterial thrombosis. Arch Pathol Lab Med 126:295–304
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Authors and Affiliations

Laboratory for Clinical Thrombosis and Hemostasis, Department of Internal Medicine, Maastricht University, Maastricht, The Netherlands
Hugo Ten Cate

Authors

Hugo Ten Cate
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Editor information

Editors and Affiliations

Institute of Physiology, University of Tuebingen, Tuebingen, Germany
Florian Lang (Prof.) (Prof.)

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Cate, H.T. (2009). Thrombosis, Arterial and Fibrinogen. In: Lang, F. (eds) Encyclopedia of Molecular Mechanisms of Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-29676-8_633

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DOI: https://doi.org/10.1007/978-3-540-29676-8_633
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-67136-7
Online ISBN: 978-3-540-29676-8
eBook Packages: Biomedical and Life SciencesReference Module Biomedical and Life Sciences

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