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Thyroiditis, Subacute

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Encyclopedia of Molecular Mechanisms of Disease

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Synonyms

De Quervain’s thyroiditis; Giant-cell thyroiditis; Pseudogranulomatous thyroiditis; Subacute painful thyroiditis; Subacute granulomatous thyroiditis [1]

Definition and Characteristics

Sudden onset of thyroid pain radiating to the jaw or ear with symptoms of hyperthyroidism transiently suppressed levels of TSH, low radioiodine uptake, elevated erythrocyte sedimentation rate, fever, malaise, which last several weeks to months [2–4]. It frequently follows an upper respiratory tract infection, and its incidence is highest in summer [2,3].

Prevalence

Subacute thyroiditis is the most common cause of thyroid pain and occurs in up to 5% of patients with clinical thyroid disease [3]. The disease is more prevalent in females than males [2,4], in a ratio of 3–6:1 [4].

Genes

There is an apparent genetic predisposition to subacute thyroiditis with human leukocyte antigen (HLA)–Bw35 association in many ethnic groups [5].

Molecular and Systemic Pathophysiology

The subacute thyroiditis is...

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References

  1. Farwell AP (2005) Subacute thyroiditis and acute infectious thyroiditis. In: Braverman LE, Utiger RD (eds) The thyroid. Lippincott Williams-Wilkins Publishers, Philadelphia, pp 536–547

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  2. Fatourechi V, Aniszewski JB, Fatourechi GZ et al. (2003) Clinical features and outcome of subacute thyroiditis in an incidence cohort: Olmsted County, Minnesota, study. J Clin Endocrinol Metab 88:2100–2105

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  3. Pearce EN, Farwell AP, Bravermann LE (2003) Thyroiditis. N Engl J Med 348:2646–2655

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  4. Tomer Y, Davies TF (1993) Infections, thyroid disease, and autoimmunity. Endocr Rev 14(1):107–120

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  5. Kramer AB, Roozendaal C, Dullaart PF (2004) Familial occurrence of subacute thyroiditis associated with human leukocyte antigen-B35. Thyroid 14(7):544–547

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Author information

Authors and Affiliations

  1. Marmara University Medical School, Istanbul, Turkey

    Seda Sancak

  2. III Medical Department, University of Leipzig, Leipzig, Germany

    Ralf Paschke

Authors
  1. Seda Sancak
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  2. Ralf Paschke
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Editor information

Editors and Affiliations

  1. Institute of Physiology, University of Tuebingen, Tuebingen, Germany

    Florian Lang (Prof.) (Prof.)

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© 2009 Springer-Verlag GmbH Berlin Heidelberg

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Sancak, S., Paschke, R. (2009). Thyroiditis, Subacute. In: Lang, F. (eds) Encyclopedia of Molecular Mechanisms of Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-29676-8_1746

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