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Zusammenfassung

Die chirurgischen Pathologien der Milz umfassen Verletzungen, hämatologische Erkrankungen und seltener fokale Veränderungen. Wenn früher bei einer traumatischen Milzruptur eine Splenektomie vorgenommen wurde, wird heute wegen der unerwünschten Folgen des Milzverlustes (»overwhelming postsplenectomy infection«) nach Möglichkeit eine Organerhaltung angestrebt. Milzerhaltende Eingriffe stellen aber wegen der hohen operativ-technischen Anforderungen eine neue Herausforderung für den Chirurgen dar. Bei verschiedenen gutartigen und malignen hämatologischen Erkrankungen nimmt wegen raffinierterer diagnostischer Verfahren und hochwirksamer Chemotherapie die diagnostische Splenektomie an Bedeutung ab. Die Indikationen zur therapeutischen Splenektomie sind bei Verdrängungssymptomatik durch sehr große Milzen und bei den Folgen des Hypersplenismus mit Anämie und/oder hämorrhagischer Diathese gegeben.

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Literatur

  • Abi F, Fares EL, Khaiz D, Bouzidi A (1989) Les localisations inhabituelles du kyste hydatique. J Surg 126:307–312

    CAS  Google Scholar 

  • Aguado MT, Mannik M (1987) Clearance kinetics and organ uptake of complement-solubilized immune complexes in mice. Immunology 60:255–260

    PubMed  CAS  Google Scholar 

  • Arnoletti JP, Karam J, Brodsky J (1999) Early postoperative complications of splenectomy for hematologic disease. Am J Clin Oncol 22:114–118

    Article  PubMed  CAS  Google Scholar 

  • Bader-Meunier B, Gauthier F, Archambaud F et al. (2001) Long-term evaluation of the beneficial effort of subtotal splenectomy for management of hereditary spherocytosis. Blood 97:399–403

    Article  PubMed  CAS  Google Scholar 

  • Bar-Maor JA (1993) Partial splenectomy in Gaucher’s disease: follow-up report. J Pediatr Surg 28:686–688

    Article  PubMed  CAS  Google Scholar 

  • Berman RS, Mansfield PF, Hemmila MR et al. (1999) Laparoscopic splenectomy in patients with hematologic malignancies. Am J Surg 178:530–534

    Article  PubMed  CAS  Google Scholar 

  • Bohner H, Tirier C, Rotzscher VM, Heit W (1997) Indications for and results of splenectomy in different hematological disorders. Langenbecks Arch Chir 382:79–82

    PubMed  CAS  Google Scholar 

  • Buchino JJ (1998) Thoracic splenosis. South Med J 91:1054–1056

    PubMed  CAS  Google Scholar 

  • Campos Christo M (1962) Segmental resections of the spleen: report on the first eight cases operated on. O Hosp 62:575–590

    Google Scholar 

  • Celebrezze JP, Cottrell DJ, Williams GB (1998) Spontaneous splenic rupture due to isolated splenic peliosis. South Med J 91:763–764

    PubMed  Google Scholar 

  • Chaffanjon PC, Brichon PY, Ranchou Y et al. (1998) Portal vein thrombosis following splenectomy for hematologic disease: prospective study with Doppler color flow imaging. World J Surg 22:1082–1086

    Article  PubMed  CAS  Google Scholar 

  • Charleux H, Julien M, Bousquet R et al. (1989) Splenectomy in hematologic diseases. Indications, technis and early results. A retrospective study of 1095 cases. Chirurgie 115:494–499

    PubMed  CAS  Google Scholar 

  • Christensen BE, Jonsson V, Matre R, Tonder O (1978) Traffic of T-and B-lymphocytes in the normal spleen. Scand J Haematol 20:246–257

    Article  PubMed  CAS  Google Scholar 

  • Cogbill TH, Moore EE, Jurkovitch GJ et al. (1989) Nonoperative management of blunt splenic trauma: a multicenter experience. J Trauma 29:1312–1317

    PubMed  CAS  Google Scholar 

  • Consentino CM, Luck SR, Barthel MJ et al. (1990) Transfusion requirements in conservative nonoperative management of blunt splenic and hepatic injuries during childhood. J Pediatr Surg 25:950–954

    Article  Google Scholar 

  • Delaitre B, Champault G, Barrat C et al. (2000) Splenectomie par voie coelioscopique. A propos de 275 cas. Ann Chir 125:522–529

    Article  PubMed  CAS  Google Scholar 

  • Delaitre B, Maignien B (1991) Splenectomie par voie coelioscopique. Presse Med 20:2263–2265

    PubMed  CAS  Google Scholar 

  • Domini A, Baccarani U, Terruso G, Corno V (1999) Laparoscopic versus open splenectomy in the management of hematologic diseases. Surg Endosc 13:1220–1224

    Article  Google Scholar 

  • Ellison EC, Fabri PJ (1983) Complications of splenectomy: etiology, prevention and management. Surg Clin N Am 63:1313–1330

    PubMed  CAS  Google Scholar 

  • Esposito TJ, Gamelli G (1997) Injury to the spleen. In: Feliciano DV, Moore EE, Mattox KL (Hrsg): Trauma, 3. Aufl. Appleton + Lange, Stanford Conn., pp 525–550

    Google Scholar 

  • Farah RA, Rogers ZR, Thomson WR, Hicks BA (1997) Comparison of laparoscopic and open splenectomy in children with hematologic disorders. J Pediatr 131:41–46

    Article  PubMed  CAS  Google Scholar 

  • Fotiadis C, Kontzoglou C, Dousaitou P et al. (1992) Indications and early results of splenectomy in hematologic diseases. Chirurgie 118:309–314

    PubMed  CAS  Google Scholar 

  • Golomb HM, Vardiman HW (1983) Response to splenectomy in 65 patients with hairy cell leukemia: an evaluation of spleen weight and bone marrow involvement. Blood 61:349–352

    PubMed  CAS  Google Scholar 

  • Gratwohl A, Goldman J, Gluckman E, Zwaan F (1985) Effect of splenectomy before bone-marrow transplantation on survival in chronic granulocytic leukaemia. Lancet 8467:1290–1291

    Article  Google Scholar 

  • Groom AC (1987) Microcirculation of the spleen: new concepts, new challenges. Microvasc Res 34:269–298

    Article  PubMed  CAS  Google Scholar 

  • Guth AA, Pachter HL, Jacobowitz GR (1996) Rupture of the pathologic spleen. Is there a role for nonoperative therapy? J Trauma 41:214–218

    PubMed  CAS  Google Scholar 

  • Hellman P, Arvidsson D, Rastad J (2000) HandPort-assisted laparoscopic splenectomy in massive splenomegaly. Surg Endosc 14:1177–9

    Article  PubMed  CAS  Google Scholar 

  • Hoefer RA, Scullin DC, Silver LF, Weakley SD (1991) Splenectomy for hematologic disorders: a 20 year experience. J Ky Med Assoc 89:446–449

    PubMed  CAS  Google Scholar 

  • Holdsworth RJ, Cuschieri A (1994) The epidemiology, pathogenesis and prevention of postsplenectomy sepsis. In: Cuschieri A, Forbes CD (eds) Disorders of the spleen. Blackwell Scientific Publications, Oxford, pp 229–239

    Google Scholar 

  • Horowitz J, Smith JL, Weber TK (1996) Postoperative complications after splenectomy for hematologic malignancies. Ann Surg 223:290–296

    Article  PubMed  CAS  Google Scholar 

  • Jockovich M, Mendeenhall NP, Sombeck MD et al. (1994) Long term complications of laparotomy in Hodgkin’s disease. Ann Surg 219:615–624

    PubMed  CAS  Google Scholar 

  • Johnson M, Shatney D (1986) Splenic injuries in adults: selective nonoperative management. South Med J 79:5–8

    PubMed  Google Scholar 

  • Katkhouda N, Mavor E (2000) Laparoscopic splenectomy. Surg Clin N Am 80:1285–1297

    Article  PubMed  CAS  Google Scholar 

  • Kehila M, Khelif A, Kharrat H et al. (1994) La splénectomie partielle au cours des thalassemies majeures. A propos de 19 cas. J Chir 131:99–103

    CAS  Google Scholar 

  • Lam KY, Yip KH, Peh WC (1999) Splenic vascular lesions: unusual features and a review of the literature. Aust N Z J Surg 69:422–425

    Article  PubMed  CAS  Google Scholar 

  • MacRae HM, Takimets WW, Reynolds T (1992) Perioperative complications of splenectomy for hematologic disease. Can J Surg 35:432–436

    PubMed  CAS  Google Scholar 

  • Mahon D, Rhodes M (2003) Laparoscopic splenectomy: size matters. Ann R Coll Surg Engl. 85:248–251

    Article  PubMed  Google Scholar 

  • Majewski JA, Upshur JK (1978) Asplenia syndrome: a study of congential anomalies in 16 cases. JAMA 240:1508–1510

    Article  Google Scholar 

  • McCormick PA, Murphy KM (2000) Splenomegaly hypersplenism and coagluation abnormalities in liver disease. Baillieres Best Pract Res Clin Gastroenterol 14:1009–1031

    Article  PubMed  CAS  Google Scholar 

  • Mesa RA, Elliott MA, Tefferi A (2000) Splenectomy in chronic myeloid leukemia and myelofibrosis with myeloid metaplasia. Blood Rev 14:121–129

    Article  PubMed  CAS  Google Scholar 

  • Moore EE, Cogbill TH, Jurkovish GJ et al. (1995) Organ injury scaling: spleen and liver. J Trauma 38:323–324

    Article  PubMed  CAS  Google Scholar 

  • Morgenstern L, Skandalakis JE (1997) Anatomy and embryology of the spleen. In: Hiatt JR, Phillips EH, Morgenstern L (eds) Surgical disease of the spleen. Springer, Berlin Heidelberg New York Tokyo, pp 15–24

    Google Scholar 

  • Morgenstern L, Rosenberg I, Geller SA (1985) Tumors of the spleen. World J Surg 9:468–476

    Article  PubMed  CAS  Google Scholar 

  • Morgenstern L, Bello JM, Fisher BL, Verham RP (1992) Clinical spectrum of lymphangiomas and lymphangiomatosis of the spleen. Am Surg 58:599–604

    PubMed  CAS  Google Scholar 

  • Narasimharao KL, Venkateswarlu K, Mitra SK, Metah S (1987) Hydatid disease of the spleen treated by cyst enucleation and splenic salvage. J Pediatr Surg 22:138–142

    Article  PubMed  CAS  Google Scholar 

  • Neal TF, Tefferi A, Witzig TE et al. (1992) Splenectomy in advanced chronic lymphocytic leukemia: a single institution experience with 50 patients. Am J Med 93:434–440

    Article  Google Scholar 

  • Nelson EW, Mone MC (1999) Splenectomy in high-risk patients with splenomegaly. Am J Surg 178:581–586

    Article  PubMed  CAS  Google Scholar 

  • Neuhauser TS, Derringer GA, Thompson LDR et al. (2000) Splenic angiosarcoma: a clinicopathologic and immunophenotypic study of 28 cases. Mod Pathol 13:978–987

    Article  PubMed  CAS  Google Scholar 

  • Nieuwenhuis P, Ford WL (1976) Comparative migration of B-and T-lymphocytes in the rat spleen and lymphnodes. Cell Immunol 23:254–67

    Article  PubMed  CAS  Google Scholar 

  • Oller B, Armergo IM, Camps I et al. (1991) Nonoperative management of splenic injuries. Am Surg 57:409–413

    PubMed  CAS  Google Scholar 

  • Park AE, Birgisson G, Mastrangelo MJ et al. (2000) Laparoscopic splenectomy: outcomes and lessons learned from over 200 cases. Surgery 128:660–667

    Article  PubMed  CAS  Google Scholar 

  • Peters AM (1983) Splenic blood flow and blood cell kinetics. Clin Haematol 12:421–447

    PubMed  CAS  Google Scholar 

  • Phillips EH, Korman JE, Friedman D (1997) Laparoscopic splenectomy. In: Hiatt JR, Phillips EH, Morgenstern L (eds) Surgical diseases of the spleen. Springer, Berlin Heidelberg New York Tokyo, pp 211–232

    Google Scholar 

  • Rau HG, Schauer R, Pickelmann S et al. (2001) Dissektionstechniken in der Leberchirurgie. Chirurg 72:105–112

    Article  PubMed  CAS  Google Scholar 

  • Ruiz-Arguelles GJ, Velazquez BM, Perez-Tamayo R et al. (1998) Splenectomy complications in hematological diseases. Rev Invest Clin 50:347–50

    PubMed  CAS  Google Scholar 

  • Sagar PM, McMahon MJ (1988) Partial splenectomy for splenic cysts. Br J Surg 75:488–490

    PubMed  CAS  Google Scholar 

  • Schnitzer B, Sodeman T, Mead ML, Cantacos PG (1972) Pitting function of the spleen in malaria. Science 177:175–177

    Article  PubMed  CAS  Google Scholar 

  • Simanski DA, Schiby G, Drezmik Z, Jacob ET (1986) Rapid progressive dissemination of hemangiosarcoma of the spleen following spontaneous rupture. World J Surg 10:142–145

    Article  Google Scholar 

  • Sirinek KR, Livingston CD, Bova JG, Levine BA (1984) Bowel obstruction due to infarcted splenosis. South Med J 77:764–767

    Article  PubMed  CAS  Google Scholar 

  • Skandalakis JE, Gray SW, Rowe JS (1989) Anatomisch bedingte Komplikationen in der Allgemeinchirurgie. Thieme, Stuttgart New York, pp 160–171

    Google Scholar 

  • Stevovic D, Digalic D, Pesko P et al. (1989) Early postoperative complications in elective splenectom yin hematologic diseases. Acta Chir Iugosl 36:257–267

    PubMed  CAS  Google Scholar 

  • Targaronna EM, Espert JJ, Cerdan G, Balague C (1999) Effect of spleen size on splenectomy outcome. A comparison of open and laparoscopic surgery. Surg Endosc 13:559–564

    Article  Google Scholar 

  • Tefferi A, Mesa RA, Nagorney DM et al. (2000) Splenectomy in myelofibrosis with myeloid metaplasia: a single-institution experience with 223 patients. Blood 95:2226–2233

    PubMed  CAS  Google Scholar 

  • Touloukian RJ, Seashore JH (1987) Partial splenic decapsulation: a simplified operation for splenic pseudosyst. J Pediatr Surg 22:137–137

    Article  Google Scholar 

  • Trunkey DD, Mulka F, Mullins RJ (1997) Splenic trauma. In: Hiatt JR, Phillips EH, Morgenstern L (eds) Surgical diseases of the spleen. Springer, Berlin Heidelberg New York Tokyo, pp 233–261

    Google Scholar 

  • Uranus S, Kronberger L, Kraft-Kine J (1994) Partial splenic resection using the TA-stapler. Am J Surg 168:49–53

    Article  PubMed  CAS  Google Scholar 

  • Vara-Thorbeck R, Rosell J, Riuz-Morales M (1991) Echinokokkose der Milz — die konservativ-chirurgische Behandlung. Zentralbl Chir 116:1411–1416

    PubMed  CAS  Google Scholar 

  • Van Ewijk W, Nieuwenhuis P (1985) Compartments, domains and migration pathways of lymphoid cells in the splenic pulp. Experienta 41:199–208

    Article  Google Scholar 

  • Van’t Riet M, Burger JW, van Muiswinkel JM et al. (2000) Diagnosis and treatment of portal vein thrombosis following splenectomy. Br J Surg 87:1229–1233

    Article  Google Scholar 

  • Velanovich V, Shurafa MS (2001) Clinical and quality of life outcomes of laparoscopic and open splenectomy fo haematological diseases. Eur J Surg 167:23–28

    Article  PubMed  CAS  Google Scholar 

  • Waghorn DJ (2001) Overwhelming infection in asplenic patients: current best practice preventive measures are not being followed. J Cvlin Pathol 54:214–218

    Article  CAS  Google Scholar 

  • Walsh RM, Brody F, Brown N (2004) Laparoscopic splenectomy for lymphoproliferative disease. Surg Endosc 18:272–275

    Article  PubMed  CAS  Google Scholar 

  • Williams RA, Mueller M, Wilson SE (1994) Splanchnic artery aneurysms. In: Veith FJ, Hobson RW, Williams RA (eds) Vascual surgery, principles and practice, 2. Aufl. McGraw-Hill, New York St. Louis, pp 580–588

    Google Scholar 

  • Wolf O, Lenner V (1998) Cystische Echinokokoose der Milz. Chirurg 69:208–211

    Article  PubMed  CAS  Google Scholar 

  • Xiros N, Economopoulos T, Christodoulidis C et al. (2000) Splenectomy in patients with malignant non-Hodgkin’s lymphoma. Eur J Haematol 64:145–150

    Article  PubMed  CAS  Google Scholar 

  • Yagmur Y, Kara IH, Aldemir M et al. (2000) Spontaneous rupture of malarial spleen. Two case reports and review of literature. Crit Care 4:309–313

    Article  PubMed  CAS  Google Scholar 

  • Yavorski CC, Greason KL, Egan MC (1998) Splenic cysts: a new approach to partial splenectomy — case report and review of the literature. Am Surg 64:795–798

    PubMed  CAS  Google Scholar 

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Oertli, D., Zuber, M. (2006). Milz. In: Schumpelick, V., Siewert, J.R., Rothmund, M. (eds) Praxis der Viszeralchirurgie. Springer, Berlin, Heidelberg . https://doi.org/10.1007/978-3-540-29042-1_97

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  • DOI: https://doi.org/10.1007/978-3-540-29042-1_97

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