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Acute Appendicitis

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Emergency General Surgery

Abstract

The treatment of acute appendicitis, one of the most common acute surgical conditions in the United States, has gone through significant changes and still has several areas of controversy. The diagnostic approach heavily relies on imaging. A negative ultrasound cannot rule out appendicitis and should be followed by CT scan. The use of antibiotics alone as the primary treatment modality for uncomplicated appendicitis has gained popularity, but although the evidence suggests it is a safe alternative to appendectomy, it is associated with significant failure rates. Patients presenting with a right lower quadrant phlegmon or abscess are better treated with nonoperative management, as immediate surgical treatment is associated with increased morbidity.

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References

  1. Fitz RH. Perforating inflammation of the vermiform appendix. Am J Med Sci 1886;92:321–346.

    Google Scholar 

  2. McBurney C. II. The indications for early laparotomy in appendicitis. Ann Surg 1891;13(4):233–254.

    Article  CAS  Google Scholar 

  3. McBurney C. IV. The incision made in the Abdominal Wall in cases of appendicitis, with a description of a new method of operating. Ann Surg 1894;20(1):38–43.

    Article  CAS  Google Scholar 

  4. Cantrell JR, Stafford ES. The diminishing mortality from appendicitis. Ann Surg 1955;141(6):749–758.

    Article  CAS  Google Scholar 

  5. Addiss DG, Shaffer N, Fowler BS, Tauxe RV. The epidemiology of appendicitis and appendectomy in the United States. Am J Epidemiol 1990;132(5):910–925.

    Article  CAS  Google Scholar 

  6. Alvarado A. A practical score for the early diagnosis of acute appendicitis. Ann Emerg Med 1986;15(5):557–564.

    Article  CAS  Google Scholar 

  7. Ohle R, O'Reilly F, O'Brien KK, Fahey T, Dimitrov BD. The Alvarado score for predicting acute appendicitis: a systematic review. BMC Med 2011;9:139.

    Google Scholar 

  8. Sun JS, Noh HW, Min YG, Lee JH, Kim JK, Park KJ, et al. Receiver operating characteristic analysis of the diagnostic performance of a computed tomographic examination and the Alvarado score for diagnosing acute appendicitis: emphasis on age and sex of the patients. J Comput Assist Tomogr 2008;32(3):386–391.

    Article  Google Scholar 

  9. SCOAP Collaborative, Cuschieri J, Florence M, Flum DR, Jurkovich GJ, Lin P, et al. Negative appendectomy and imaging accuracy in the Washington state surgical care and outcomes assessment program. Ann Surg 2008;248(4):557–563.

    Google Scholar 

  10. Poortman P, Oostvogel HJM, Bosma E, Lohle PNM, Cuesta MA, de Lange-de Klerk ESM, et al. Improving diagnosis of acute appendicitis: results of a diagnostic pathway with standard use of ultrasonography followed by selective use of CT. J Am Coll Surg 2009;208(3):434–441.

    Article  Google Scholar 

  11. Cobben L, Groot I, Kingma L, Coerkamp E, Puylaert J, Blickman J. A simple MRI protocol in patients with clinically suspected appendicitis: results in 138 patients and effect on outcome of appendectomy. Eur Radiol 2009;19(5):1175–1183.

    Article  Google Scholar 

  12. Singh A, Danrad R, Hahn PF, Blake MA, Mueller PR, Novelline RA. MR imaging of the acute abdomen and pelvis: acute appendicitis and beyond. Radiographics 2007;27(5):1419–1431.

    Article  Google Scholar 

  13. Tekin A, Kurtoğlu HC, Can I, Öztan S. Routine interval appendectomy is unnecessary after conservative treatment of appendiceal mass. Color Dis 2008;10(5):465–8.

    Article  CAS  Google Scholar 

  14. Rosen MP, Ding A, Blake MA, Baker ME, Cash BD, Fidler JL, et al. ACR appropriateness criteria® right lower quadrant pain—suspected appendicitis. J Am Coll Radiol 2011;8(11):749–755.

    Article  Google Scholar 

  15. Varadhan KK, Neal KR, Lobo DN. Safety and efficacy of antibiotics compared with appendicectomy for treatment of uncomplicated acute appendicitis: meta-analysis of randomised controlled trials. BMJ 2012;344:e2156.

    Article  Google Scholar 

  16. Vons C, Barry C, Maitre S, Pautrat K, Leconte M, Costaglioli B, et al. Amoxicillin plus clavulanic acid versus appendicectomy for treatment of acute uncomplicated appendicitis: an open-label, non-inferiority, randomised controlled trial. Lancet 2011;377(9777):1573–1579.

    Article  CAS  Google Scholar 

  17. Styrud J, Eriksson S, Nilsson I, Ahlberg G, Haapaniemi S, Neovius G, et al. Appendectomy versus antibiotic treatment in acute appendicitis. A prospective multicenter randomized controlled trial. World J Surg 2006;30(6):1033–1037.

    Article  Google Scholar 

  18. Hansson J, Körner U, Ludwigs K, Johnsson E, Jönsson C, Lundholm K. Antibiotics as first-line therapy for acute appendicitis: evidence for a change in clinical practice. World J Surg 2012;36(9):2037–2038.

    Article  Google Scholar 

  19. Eriksson S, Granström L. Randomized controlled trial of appendicectomy versus antibiotic therapy for acute appendicitis. Br J Surg 1995;82(2):166–169.

    Article  CAS  Google Scholar 

  20. Farahnak M, Talaei-Khoei M, Gorouhi F, Jalali A, Gorouhi F. The Alvarado score and antibiotics therapy as a corporate protocol versus conventional clinical management: randomized controlled pilot study of approach to acute appendicitis. Am J Emerg Med 2007;25(7):3–3.

    Article  Google Scholar 

  21. Mason RJ, Moazzez A, Sohn H, Katkhouda N. Meta-analysis of randomized trials comparing antibiotic therapy with appendectomy for acute uncomplicated (no abscess or phlegmon) appendicitis. Surg Infect 2012;13(2):74–84.

    Article  Google Scholar 

  22. Di Saverio S, Sibilio A, Giorgini E, Biscardi A, Villani S, Coccolini F, et al. The NOTA study (non operative treatment for acute appendicitis): prospective study on the efficacy and safety of antibiotics (amoxicillin and clavulanic acid) for treating patients with right lower quadrant abdominal pain and long-term follow-up of conservatively treated suspected appendicitis. Ann Surg 2014;260(1):109–117.

    Google Scholar 

  23. Salminen P, Paajanen H, Rautio T, Nordström P, Aarnio M, Rantanen T, et al. Antibiotic therapy vs appendectomy for treatment of uncomplicated acute appendicitis: the APPAC randomized clinical trial. JAMA 2015;313(23):2340–2348.

    Article  CAS  Google Scholar 

  24. Livingston E, Vons C. Treating appendicitis without surgery. JAMA 2015;313(23):2327–2328.

    Article  CAS  Google Scholar 

  25. Flum DR. Clinical practice. Acute appendicitis--appendectomy or the “antibiotics first” strategy. N Engl J Med 2015;372(20):1937–1943.

    Article  Google Scholar 

  26. Andersson RE, Petzold MG. Nonsurgical treatment of appendiceal abscess or phlegmon: a systematic review and meta-analysis. Ann Surg 2007;246(5):741–748.

    Article  Google Scholar 

  27. Semm K. Endoscopic appendectomy. Endoscopy 1983;15(2):59–64.

    Article  CAS  Google Scholar 

  28. Anderson JE, Bickler SW, Chang DC, Talamini MA. Examining a common disease with unknown etiology: trends in epidemiology and surgical Management of Appendicitis in California, 1995-2009. World J Surg 2012, 36, 2787.

    Article  Google Scholar 

  29. Bulian DR, Knuth J, Sauerwald A, Ströhlein MA, Lefering R, Ansorg J, et al. Appendectomy in Germany-an analysis of a nationwide survey 2011/2012. Int J Color Dis 2012;28(1):127–138.

    Article  Google Scholar 

  30. Ingraham AM, Cohen ME, Bilimoria KY, Ko CY, Hall BL, Russell TR, et al. Effect of delay to operation on outcomes in adults with acute appendicitis. Arch Surg 2010;145(9):886–892.

    Article  Google Scholar 

  31. Ingraham AM, Cohen ME, Bilimoria KY, Pritts TA, Ko CY, Esposito TJ. Comparison of outcomes after laparoscopic versus open appendectomy for acute appendicitis at 222 ACS NSQIP hospitals. Surgery 2010;148(4):625–35–discussion635–7..

    Article  Google Scholar 

  32. Kim MJ, Fleming FJ, Gunzler DD, Messing S, Salloum RM, Monson JRT. Laparoscopic appendectomy is safe and efficacious for the elderly: an analysis using the National Surgical Quality Improvement Project database. Surg Endosc 2011;25(6):1802–1807.

    Article  Google Scholar 

  33. Page AJ, Pollock JD, Perez S, Davis SS, Lin E, Sweeney JF. Laparoscopic versus open appendectomy: an analysis of outcomes in 17,199 patients using ACS/NSQIP. J Gastrointest Surg 2010;14(12):1955–1962.

    Article  Google Scholar 

  34. Martin LC, Puente I, Sosa JL, Bassin A, Breslaw R, McKenney MG, et al. Open versus laparoscopic appendectomy. A prospective randomized comparison. Ann Surg 1995;222(3):256–61–discussion261–2..

    Article  CAS  Google Scholar 

  35. Tan-Tam C, Yorke E, Wasdell M, Barcan C, Konkin D, Blair P. The benefits of laparoscopic appendectomies in obese patients. Am J Surg 2012;203(5):609–612.

    Article  Google Scholar 

  36. Tuggle KR-M, Ortega G, Bolorunduro OB, Oyetunji TA, Alexander R, Turner PL, et al. Laparoscopic versus open appendectomy in complicated appendicitis: a review of the NSQIP database. J Surg Res 2010;163(2):225–228.

    Article  Google Scholar 

  37. Katkhouda N, Mason RJ, Towfigh S, Gevorgyan A, Essani R. Laparoscopic versus open appendectomy: a prospective randomized double-blind study. Ann Surg 2005;242(3):439.

    Google Scholar 

  38. Mason RJ, Moazzez A, Moroney JR, Katkhouda N. Laparoscopic vs open appendectomy in obese patients: outcomes using the American College of Surgeons National Surgical Quality Improvement Program database. J Am Coll Surg 2012;215(1):88–99–discussion99–100..

    Article  Google Scholar 

  39. Tzovaras G, Baloyiannis I, Kouritas V, Symeonidis D, Spyridakis M, Poultsidi A, et al. Laparoscopic versus open appendectomy in men: a prospective randomized trial. Surg Endosc 2010;24(12):2987–2992.

    Article  Google Scholar 

  40. Li X, Zhang J, Sang L, Zhang W, Chu Z, Li X, et al. Laparoscopic versus conventional appendectomy--a meta-analysis of randomized controlled trials. BMC Gastroenterol 2010;10:129.

    Google Scholar 

  41. Guller U, Hervey S, Purves H, Muhlbaier LH, Peterson ED, Eubanks S, et al. Laparoscopic versus open appendectomy: outcomes comparison based on a large administrative database. Ann Surg 2004;239(1):43–52.

    Article  Google Scholar 

  42. Sauerland S, Jaschinski T, Neugebauer EA. Laparoscopic versus open surgery for suspected appendicitis. Cochrane Database Syst Rev 2010;(10):CD001546.

    Google Scholar 

  43. Fleming FJ, Kim MJ, Messing S, Gunzler D, Salloum R, Monson JR. Balancing the risk of postoperative surgical infections: a multivariate analysis of factors associated with laparoscopic appendectomy from the NSQIP database. Ann Surg 2010;252(6):895–900.

    Article  Google Scholar 

  44. Yardeni D, Hirschl RB, Drongowski RA, Teitelbaum DH, Geiger JD, Coran AG. Delayed versus immediate surgery in acute appendicitis: do we need to operate during the night? J Pediatr Surg 2004;39(3):464–469.

    Article  Google Scholar 

  45. Abou-Nukta FF, Bakhos CC, Arroyo KK, Koo YY, Martin JJ, Reinhold RR, et al. Effects of delaying appendectomy for acute appendicitis for 12 to 24 hours. Arch Surg 2006;141(5):504–507.

    Article  Google Scholar 

  46. Kearney D, Cahill RA, O'Brien E, Kirwan WO, Redmond HP. Influence of delays on perforation risk in adults with acute appendicitis. Dis Colon Rectum 2008;51(12):1823–1827.

    Article  CAS  Google Scholar 

  47. Stahlfeld K, Hower J, Homitsky S, Madden J. Is acute appendicitis a surgical emergency? Am Surg 2007 73(6):626–9–discussion629–30..

    Google Scholar 

  48. Busch M, Gutzwiller FS, Aellig S, Kuettel R, Metzger U, Zingg U. In-hospital delay increases the risk of perforation in adults with appendicitis. World J Surg 2011;35(7):1626–1633.

    Article  Google Scholar 

  49. Ditillo MFM, Dziura JDJ, Rabinovici RR. Is it safe to delay appendectomy in adults with acute appendicitis? Ann Surg 2006;244(5):656–660.

    Article  Google Scholar 

  50. Omundsen M, Dennett E. Delay to appendicectomy and associated morbidity: a retrospective review. ANZ J Surg 2006;76(3):153–155.

    Article  Google Scholar 

  51. Teixeira PGR, Sivrikoz E, Inaba K, Talving P, Lam L, Demetriades D. Appendectomy timing: waiting until the next morning increases the risk of surgical site infections. Ann Surg 2012;256(3):538–543.

    Article  Google Scholar 

  52. Solomkin JS, Mazuski JE, Bradley JS, Rodvold KA, Goldstein EJC, Baron EJ, et al. Diagnosis and management of complicated intra-abdominal infection in adults and children: guidelines by the surgical infection society and the Infectious Diseases Society of America. Surg Infect 2010;11(1):79–109.

    Article  Google Scholar 

  53. van Rossem CC, Schreinemacher MHF, Treskes K, van Hogezand RM, van Geloven AAW. Duration of antibiotic treatment after appendicectomy for acute complicated appendicitis. Br J Surg 2014;101(6):715–719.

    Article  CAS  Google Scholar 

  54. van Rossem CC, Schreinemacher MHF, van Geloven AAW, Bemelman WA, Snapshot appendicitis collaborative study group. Antibiotic duration after laparoscopic appendectomy for acute complicated appendicitis. JAMA Surg 2016;151(4):323–329.

    Article  Google Scholar 

  55. Tamir IL, Bongard FS, Klein SR. Acute appendicitis in the pregnant patient. Am J Surg 1990;160(6):571–5–discussion575–6..

    Article  CAS  Google Scholar 

  56. Mazze RI, Källén B. Appendectomy during pregnancy: a Swedish registry study of 778 cases. Obstet Gynecol 1991;77(6):835–840.

    Google Scholar 

  57. Wei P-L, Keller JJ, Liang H-H, Lin H-C. Acute appendicitis and adverse pregnancy outcomes: a nationwide population-based study. J Gastrointest Surg 2012;16(6):1204–1211.

    Article  Google Scholar 

  58. Andersen B, Nielsen TF. Appendicitis in pregnancy: diagnosis, management and complications. Acta Obstet Gynecol Scand 1999;78(9):758–762.

    Article  CAS  Google Scholar 

  59. Yilmaz HG, Akgun Y, Bac B, Celik Y. Acute appendicitis in pregnancy--risk factors associated with principal outcomes: a case control study. Int J Surg 2007;5(3):192–7.

    Article  Google Scholar 

  60. Ueberrueck T, Koch A, Meyer L, Hinkel M, Gastinger I. Ninety-four appendectomies for suspected acute appendicitis during pregnancy. World J Surg 2004;28(5):508–511.

    Article  Google Scholar 

  61. Hale DA, Molloy M, Pearl RH, Schutt DC, Jaques DP. Appendectomy: a contemporary appraisal. Ann Surg 1997;225(3):252–261.

    Article  CAS  Google Scholar 

  62. Hée P, Viktrup L. The diagnosis of appendicitis during pregnancy and maternal and fetal outcome after appendectomy. Int J Gynaecol Obstet 1999;65(2):129–135.

    Article  Google Scholar 

  63. McGory ML, Zingmond DS, Tillou A, Hiatt JR, Ko CY, Cryer HM. Negative appendectomy in pregnant women is associated with a substantial risk of fetal loss. J Am Coll Surg 2007;205(4):534–540.

    Article  Google Scholar 

  64. Lim HK, Bae SH, Seo GS. Diagnosis of acute appendicitis in pregnant women: value of sonography. AJR Am J Roentgenol 1992;159(3):539–542.

    Article  CAS  Google Scholar 

  65. Jaffe TA, Miller CM, Merkle EM. Practice patterns in imaging of the pregnant patient with abdominal pain: a survey of academic centers. AJR Am J Roentgenol 2007;189(5):1128–1134.

    Article  Google Scholar 

  66. Kanal EE, Borgstede JPJ, Barkovich AJA, Bell CC, Bradley WGW, Felmlee JPJ, et al. 2002 American College of Radiology White Paper on MR safety. AJR. 178, 1335–1347.

    Article  Google Scholar 

  67. Hunter JG, Swanstrom L, Thornburg K. Carbon dioxide pneumoperitoneum induces fetal acidosis in a pregnant ewe model. Surg Endosc 1995;9(3):272–7–discussion277–9..

    Google Scholar 

  68. Wilasrusmee C, Sukrat B, McEvoy M, Attia J, Thakkinstian A. Systematic review and meta-analysis of safety of laparoscopic versus open appendicectomy for suspected appendicitis in pregnancy. Br J Surg 2012;99(11):1470–1478.

    Article  CAS  Google Scholar 

  69. Wen SW, Hernandez R, Naylor CD. Pitfalls in nonrandomized outcomes studies. The case of incidental appendectomy with open cholecystectomy. JAMA 1995;274(21):1687–1691.

    Article  CAS  Google Scholar 

  70. Sugimoto T, Edwards D. Incidence and costs of incidental appendectomy as a preventive measure. Am J Public Health 1987;77(4):471–475.

    Article  CAS  Google Scholar 

  71. Wang HT, Sax HC. Incidental appendectomy in the era of managed care and laparoscopy. J Am Coll Surg 2001;192(2):182–188.

    Google Scholar 

  72. Puapong D, Lee SL, Haigh PI, Kaminski A, Liu I-LA, Applebaum H. Routine interval appendectomy in children is not indicated. J Pediatr Surg 2007;42(9):1500–1503.

    Article  Google Scholar 

  73. Hall NJ, Jones CE, Eaton S, Stanton MP, Burge DM. Is interval appendicectomy justified after successful nonoperative treatment of an appendix mass in children? A systematic review. J Pediatr Surg 2011;46(4):767–771.

    Article  Google Scholar 

  74. Oliak D, Yamini D, Udani VM, Lewis RJ, Arnell T, Vargas H, et al. Initial nonoperative management for periappendiceal abscess. Dis Colon Rectum 2001;44(7):936–941.

    Article  CAS  Google Scholar 

  75. Willemsen PJ, Hoorntje LE, Eddes E-H, Ploeg RJ. The need for interval appendectomy after resolution of an Appendiceal mass questioned. Dig Surg 2002;19(3):216–222.

    Article  Google Scholar 

  76. Lugo JZ, Avgerinos DV, Lefkowitz AJ, Seigerman ME, Zahir IS, Lo AY, et al. Can interval appendectomy be justified following conservative treatment of perforated acute appendicitis? J Surg Res 2010;164(1):91–94.

    Article  Google Scholar 

  77. Eriksson S, Styrud J. Interval appendicectomy: a retrospective study. Eur J Surg 2003;164(10):771–774.

    Article  Google Scholar 

  78. Iqbal CW, Knott EM, Mortellaro VE, Fitzgerald KM, Sharp SW, St Peter SD. Interval appendectomy after perforated appendicitis: what are the operative risks and luminal patency rates? J Surg Res 2012;177(1):127–130.

    Article  Google Scholar 

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Correspondence to Pedro G. R. Teixeira .

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Bankhead-Kendall, B., Teixeira, P.G.R. (2019). Acute Appendicitis. In: Brown, C., Inaba, K., Martin, M., Salim, A. (eds) Emergency General Surgery. Springer, Cham. https://doi.org/10.1007/978-3-319-96286-3_21

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