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Choledocholithiasis

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Emergency General Surgery
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Abstract

Choledocholithiasis, the presence of gallstones in the common bile duct, is a common complication of cholelithiasis. It is diagnosed using the combination of history and physical examination findings, laboratory values suggestive of cholestasis, and imaging, including ultrasound, CT scan, and various forms of cholangiography. Once choledocholithiasis is diagnosed, stone extraction is recommended, which can be accomplished by ERCP, PTC, or common bile duct exploration. Same-admission cholecystectomy should follow stone extraction. Physicians who manage choledocholithiasis must also be aware of the acute and chronic complications. This chapter reviews the epidemiology, pathophysiology, diagnosis, management, and complications of choledocholithiasis.

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References

  1. Stinton L, Shaffer E. Epidemiology of gallbladder disease: cholelithaisis and cancer. Gut Liver. 2012;6(2):172–87.

    Article  Google Scholar 

  2. Krawczyk M, Stoeks C, Lammert F. Genetics and treatment of bile duct stones: new approaches. Curr Opin Gastroenterol. 2013;29(3):329–35.

    Article  CAS  Google Scholar 

  3. Peng WK, Sheikh Z, Paterson-Brown S, et al. Role of liver function tests in predicting common bile duct stones in patients with acute calculous cholecystitis. Br J Surg. 2005;92:1241–7.

    Article  CAS  Google Scholar 

  4. Onken JE, Brazer SR, Eisen GM, et al. Predicting the presence of choledocholithiasis in patients with symptomatic cholelithiasis. Am J Gastroenterol. 1996;91:762–7.

    CAS  PubMed  Google Scholar 

  5. Abboud PAC, Malet PF, Berlin JA, Staroscik R, Cabana MDC, Clarke JR, Shea JA, Schwartz JS, Williams SV. Predictors of common bile duct stones prior to cholecystectomy: a meta-analysis. Gastrointest Endosc. 1996;44:450–9.

    Article  CAS  Google Scholar 

  6. Padda MS, Singh S, Tang SJ, Rockey DC. Liver test patterns in patients with acute calculous cholecystitis and/or choledocholithiasis. Aliment Pharmacol Ther. 2009;29:1011–8.

    Article  CAS  Google Scholar 

  7. Bourgouin S, Truchet X, Lamblin G, De Roulhae J, Platel JP, Balandraud P. Dynamic analysis of commonly used biochemical parameters to predict common bile duct stones in patients undergoing laparoscopic cholecystectomy. Surg Endosc. 2017;31(11):4725–34. Epub ahead of print.

    Article  Google Scholar 

  8. American Society for Gastrointestinal Endoscopy. The role of endoscopy in the evaluation of suspected choledocholithiasis. Gastrointest Endosc. 2010;71(1):1–9.

    Article  Google Scholar 

  9. Barkun AN, Barkun JS, Fried GM, et al. Useful predictors of bile duct stones in patients undergoing laparoscopic cholecystectomy. Ann Surg. 1994;220:32–9.

    Article  CAS  Google Scholar 

  10. Tse F, Barkun JS, Barkun AN. The elective evaluation of patients with suspected choledocholithiasis undergoing laparoscopic cholecystectomy. Gastrointest Endosc. 2004;60(3):437–48.

    Article  Google Scholar 

  11. Epelboym I, Winner M, Allendorf JD. MRCP is not a cost-effective strategy in the management of silent common bile duct stones. J Gastrointest Surg. 2013;17:863–71.

    Article  Google Scholar 

  12. Verma D, Kapadia A, Eisen GM, et al. EUS vs MRCP for detection of choledocholithiasis. Gastrointest Endosc. 2006;64:248–54.

    Article  Google Scholar 

  13. Romagnuolo J, Bardou M, Rahme E, et al. Magnetic resonance cholangiopancreatography: a meta-analysis of test performance in suspected biliary disease. Ann Intern Med. 2003;139:547–57.

    Article  Google Scholar 

  14. Machi J, Tateishi T, Oishi AJ, et al. Laparoscopic ultrasonography versus operative cholangiography during laparoscopic cholecystectomy: review of the literature and a comparison with open intraoperative ultrasonography. J Am Coll Surg. 1999;188:361–7.

    Article  Google Scholar 

  15. Garrow D, Miller S, Sinha D, et al. Endoscopic ultrasound: a meta-analysis of test performance in suspected biliary obstruction. Clin Gastroenterol Hepatol. 2007;6:616–23.

    Article  Google Scholar 

  16. Sahu MJ, Chacko A, Dutta AK, Prakash JAJ. Microbial profile and antibiotic sensitivity pattern in acute bacterial cholangitis. Indian J Gastroenterol. 2011;30(5):204–8.

    Article  Google Scholar 

  17. Solomkin JS, Mazuski JE, Baron EJ, Sawyer RG, Nathens AB, DiPiro JT, Buchman T, Dellinger EP, Jernigan J, Gorbach S, Chow AW, Bartlett J. Guidelines for the selection of anti-infective agents for complicated intra-abdominal infections. Clin Infect Dis. 2003;37:997–1005.

    Article  Google Scholar 

  18. Lai KH, Chan HH, Tsai TJ, Cheng JS, Hsu PI. Reappraisal of endoscopic papillary balloon dilation for the management of common bile duct stones. World J Gastrointest Endosc. 2015;7:77–86.

    Article  Google Scholar 

  19. Yasuda I, Fujita N, Maguchi H, Hasebe O, Igarashi Y, Murakami A, Mukai H, Fujii T, Yamao K, Maeshiro K, Tada T, Tsujino T, Komatsu Y. Long-term outcomes after endoscopic sphincterotomy versus endoscopic papillary balloon dilation for bile duct stones. Gastrointest Endosc. 2010;72(6):1185–91.

    Article  Google Scholar 

  20. Fujita N, Maguchi H, Komatsu Y, Yasuda I, Hasebe O, Igarashi Y, Murakami A, Mukai H, Fujii T, Yamao K, Maeshiro K, JESED Study Group. Endoscopic sphincterotomy and endoscopic papillary balloon dilatation for bile duct stones: a prospective randomized controlled multicenter trial. Gastrointest Endosc. 2003;57(2):151–5.

    Article  Google Scholar 

  21. Binmoeller KF, Bruckner M, Thonke F, Soehendra N. Treatment of difficult bile duct stones using mechanical, electrohydraulic, and extracorporeal shock wave lithotripsy. Endoscopy. 1993;25:201–6.

    Article  CAS  Google Scholar 

  22. Wan XJ, Xu ZJ, Zhu F, Li L. Success rate and complications of endoscopic extraction of common bile duct stones over 2 cm in diameter. Hepatobiliary Pancreat Dis Int. 2011;10(4):403–7.

    Article  Google Scholar 

  23. Freeman ML, Nelson DB, Sherman S, Haber GB, Herman ME, Dorsher PJ, Moore JP, Fennerty MB, Ryan ME, Shaw MJ, Lande JD, Pheley AM. Complications of endoscopic biliary sphincterotomy. N Engl J Med. 1986;335:909–18.

    Article  Google Scholar 

  24. Surick B, Washington M, Ghazi A. Endoscopic retrograde cholangiopancreatography in conjunction with laparoscopic cholecystectomy. Surg Endosc. 1993;7(5):388–92.

    Article  CAS  Google Scholar 

  25. Cohen S, Bacon BR, Berlin JA, Fleischer D, Hecht GA, Loehrer PJ, McNair AE, Mulholland M, Norton NJ, Rabeneck L, Ransohoff DF, Sonnenberg A, Vannier MW. Gastrointest Endosc. 2002;56(6):803–9.

    Article  Google Scholar 

  26. Topal B, Aerts R, Penninckx F. Laparoscopic common bile duct stone clearance with flexible choledochoscopy. Surg Endosc. 2007;21:2317–21.

    Article  CAS  Google Scholar 

  27. Mellinger JD, MacFayden BD. Laparoscopic common bile duct exploration. In: Cameron JL, editor. Current surgical therapy. 9th ed. Philadelphia: Mosby; 2008.

    Google Scholar 

  28. Tinoco R, Tinoco A, El-Kadre L, Peres L, Sueth D. Laparoscopic common bile duct exploration. Ann Surg. 2008;247:674–9.

    Article  Google Scholar 

  29. Petelin JB. Laparoscopic common bile duct exploration. Surg Endosc. 2003;17:1705–15.

    Article  CAS  Google Scholar 

  30. Zhang W, Li G, Chen YL. Should T-tube drainage be performed for choledocholithiasis after laparoscopic common bile duct exploration? A systematic review and meta-analysis of randomized controlled trials. Surg Laparosc Endosc Percutan Tech. 2017.; Epub ahead of print.;27:415.

    Article  Google Scholar 

  31. Podda M, Polignano FM, Luhmann A, Wilson MS, Kulli C, Tait IS. Systematic review with meta-analysis of studies comparing primary duct closure and T-tube drainage after laparoscopic common bile duct exploration for choledocholithiasis. Surg Endosc. 2016;30(3):845–61.

    Article  Google Scholar 

  32. Gurusamy KS, Koti R, Davidson BR. T-tube drainage versus primary closure after open common bile duct exploration. Cochrane Database Syst Rev. 2013;21(6):CD005640.

    Google Scholar 

  33. da Costa DW, Bouwense SA, Schepers NJ, Besselink MG, van Santvoort HC, van Brunschot S, Bakker OJ, Bollen TL, Dejong CH, van Goor H, Boermeester MA, Bruno MJ, van Eijck CH, Timmer R, Weusten BL, Consten EC, Brink MA, Spanier BWM, Bilgen EJS, Nieuwenhuijs VB, Hofker HS, Rosman C, Voorburg AM, Bosscha K, Duijvendijk v, Gerritsen JJ, Heisterkamp J, de Hingh IH, Witteman BJ, Kruyt PM, Scheepers JJ, Molenaar IQ, Schaapherder AF, Manusama ER, van der Waaij LA, van Unen J, Dijkgraaf MG, van Ramshorst B, Gooszen HG, Boerma D, Dutch Pancreatitis Study Group. Same-admission versus interval cholecystectomy for mild gallstone pancreatitis (PONCHO): a multicenter randomised controlled trial. Lancet. 2015;386:1261–8.

    Article  Google Scholar 

  34. da Costa DW, Dijksman LM, Bouwense SA, Schepers NJ, Besselink MG, van Santvoort HC, Boerma D, Gooszen HG, Dijkgraaf MG, Dutch Pancreatitis Study Group. Cost-effectiveness of same-admission versus interval cholecystectomy after mild gallstone pancreatitis in the PONCHO trial. Br J Surg. 2016;103(12):1695–703.

    Article  Google Scholar 

  35. Mattila A, Mrena J, Kellokumpu I. Cost-analysis and effectiveness of one-stage laparoscopic versus two-stage endolaparoscopic mangement of cholecystocholedocholithiasis: a retrospective cohort study. BMC Surg. 2017;17:79–86.

    Article  Google Scholar 

  36. Baucom RB, Feurer ID, Shelton JS, Kummerow K, Holzman MD, Poulose BK. Surgeons, ERCP, and laparoscopic common bile duct exploration: do we need a standard approach for common bile duct stones? Surg Endosc. 2016;30(2):414–23.

    Article  Google Scholar 

  37. Saik RP, Greenburg AG, Farris JM, Peskin GW. Spectrum of cholangitis. Am J Surg. 1975;130(2):143–50.

    Article  CAS  Google Scholar 

  38. Kiriyama S, Takada T, Strasberg SM, Solomkin JS, Mayumi T, Pitt HA, Gouma DJ, Garden J, Buchler MW, Yokoe M, Kimura Y, Tsuyuguchi T, Itoi T, Yoshida M, Miura F, Yamashita Y, Okamoto K, Gabata T, Hata J, Higuchi R, Windsor JA, Bornnman PC, Fan ST, Singh H, de Santibanes E, Gomi H, Kusachi S, Murata A, Chen XP, Jagannath P, Lee SG, Padbury R, Chen MF, Dervenis C, Chan ACW, Supe AN, Liau KH, Kim MH, Kim SW. TG13 guidelines for diagnosis and severity grading of acute cholangitis. J Hepatobiliary Pancreat Sci. 2013;20:24–34.

    Article  Google Scholar 

  39. Forsmark CE, Baillie J, AGA Institute Clinical Practice and Economics Committee, AGA Institute Governing Board. AGA Institute technical review on acute pancreatitis. Gastroenterology. 2007;132(5):2022–44.

    Article  CAS  Google Scholar 

  40. Hernandez V, Pascual I, Almela P, Anon R, Herreros B, Sanchiz V, Minguez M, Benages A. Recurrence of acute gallstone pancreatitis and relationship with cholecystectomy or endoscopic sphincterotomy. Am J Gastroenterol. 2004;99(12):2417–23.

    Article  Google Scholar 

  41. Mori T, Sugiyama M, Atomi Y. Gallstone disease: management of intrahepatic stones. Best Pract Res Clin Gastroenterol. 2006;20(6):1117–37.

    Article  Google Scholar 

  42. Kim YT, Byun JS, Kim J, Jang YH, Lee WJ, Ryu JK, Kim SW, Yoon YB, Kim CY. Factors predicting concurrent cholangiocarcinomas associated with hepatolithiasis. Hepato-Gastroenterology. 2003;50(49):8–12.

    PubMed  Google Scholar 

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Correspondence to Meghan Lewis .

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Schellenberg, M., Lewis, M. (2019). Choledocholithiasis. In: Brown, C., Inaba, K., Martin, M., Salim, A. (eds) Emergency General Surgery. Springer, Cham. https://doi.org/10.1007/978-3-319-96286-3_11

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  • DOI: https://doi.org/10.1007/978-3-319-96286-3_11

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