Abstract
The neural system, including the brain and the spinal cord, consists of its structural units, the neurons whose main characteristic is the incapacity for reproduction or renewal, resulting to damages not being able to be repaired. Consequently, there are a number of diseases called neurodegenerative diseases, which affect the neurons of the human brain. They are a type of diseases that are widely spread, significantly preoccupying the scientific community, as the number of patients is expected to rise even more in the following years. The diseases are classified into two main categories based on the clinical picture of the patients and the topography of the dominant lesions. There will be description of the main diseases, namely Alzheimer’s, Parkinson, Huntington, ALS, as to the causes and the symptoms both emotionally and behaviorally. The main aim is the contact with the neurodegenerative diseases, their causes, their symptomatology as well as with the factors that reinforce the possibilities of their appearance which are grouped into two types, genetic and environmental. There has been significant progress in their treatment and in the guidelines given to caretakers. Nonetheless, they both result in the deceleration of the disease course and not in the complete cure as the brain damages are permanent.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Defne A. Amado, Beverly L. Davidson, Gene Therapy for ALS: A Review, 2021, (https://www.sciencedirect.com/science/article/pii/S1525001621001957)
Miquel Baquero, Nuria Martin, Depressive Symptoms in Neurodegenerative Disease, 2015, (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539408/)
Biba Stanton, Nigel Leigh, Robert Howard, Gareth Barker, Richard Brown, Behavioural and Emotional Symptoms of Apathy are Associated with Distinct Patterns of Brain Atrophy in Neurodegenerative Disorders, (https://link.springer.com/article/10.1007/s00415-013-6989-9)
Casey Brown, Sandy Lwi, Madeleine Goodkind, Katherine Rankin, Jennifer Merrilees, Bruce Miller, Robert Levenson, Empathic Accuracy Deficits in Patients with Neurodegenerative Disease: Association with Caregiver Depression, 2018 (https://www.sciencedirect.com/science/article/abs/pii/S106474811730516X)
Johnathan Cooper-Knock, Rare Variant Burden Analysis within Enhancers Identifies CAV1 as an ALS Risk Gene, 2020, (https://www.sciencedirect.com/science/article/pii/S2211124720314455)
Nur Eliza, Alzheimer, 2020, (https://www.academia.edu/43825463/Alzheimer)
Francis Grenn, Anni Moore, Sara Bandres-Ciga, Lynne Krohn, Cornelis Blauwendraat, Assessment of ANG Variants in Parkinson’s Disease, 2021, (https://www.sciencedirect.com/science/article/pii/S019745802100097X)
Harleen Kohli, Pravir Kumar, Rashmi Ambasta, In Silico Designing of Putative Peptides for Targeting Pathological Protein Htt in Huntington’s Disease, (https://www.sciencedirect.com/science/article/pii/S2405844021001936)
Robert W. Levenson, Virginia E. Sturm, Claudia M. Haase, Emotional and Behavioral Symptoms in Neurodefenerative Disease: A Model for Studying the Neural Bases of Psychopathology, 2014, (https://www.annualreviews.org/doi/full/10.1146/annurev-clinpsy-032813-153653)
Ratko Radakovic, Sharon Abrahams, Current Opinion in Behavioral Sciences, 2018 (https://www.sciencedirect.com/science/article/pii/S2352154617302140)
P Robert, C U Onyike, A F G Leentjens, K Dujardin, P Aalten, S Starkstein, F R J Verhey, J Yessavage, J P Clement, D Drapier, F Bayle, M Benoit, P Boyer, P M Lorca, F Thibaut, S Gauthier, G Grossberg, B Vellas, J Byrne, Proposed diagnostic criteria for apathy in Alzheimer's disease and other neuropsychiatric disorders, 2009, (https://pubmed.ncbi.nlm.nih.gov/19201579/)
Jennifer Shadrach, Translatomic Analysis of Regenerating and Degenerating Spinal Motor Neurone in Injury and ALS, 2021 (https://www.sciencedirect.com/science/article/pii/S2589004221006684)
Si Ching LIM, Managing behavioral and Psychological Symptoms of Dementia-from a Geriatricians Perspective, 2017 (https://www.alliedacademies.org/articles/managing-behavioral-and-psychological-symptoms-of-dementia-from-a-geriatricians-perspective-8032.html)
Gregory Sprenger, The prevalence of pain in Huntington’s Disease in a large worldwide cohort, 2021, (https://www.sciencedirect.com/science/article/pii/S1353802021002273)
Josh Woolley, Baber Khan, Nikhil Murthy, Bruce Miller, Katherine Rankin, The Diagnostic Challenge of Psychiatric Symptoms in Neurodegenerative Disease: Rates if and Risk Factors for Prior Psychiatric Diagnosis in Patients With Early Neurodegenerative Disease, 2010, (https://www.psychiatrist.com/jcp/depression/diagnostic-challenge-psychiatric-symptoms-neurodegenerative/)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2023 Springer Nature Switzerland AG
About this entry
Cite this entry
Lamprini, K. (2023). Emotional and Behavioral Symptoms in Neurodegenerative Diseases. In: Vlamos, P., Kotsireas, I.S., Tarnanas, I. (eds) Handbook of Computational Neurodegeneration. Springer, Cham. https://doi.org/10.1007/978-3-319-75922-7_3
Download citation
DOI: https://doi.org/10.1007/978-3-319-75922-7_3
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-75921-0
Online ISBN: 978-3-319-75922-7
eBook Packages: Biomedical and Life SciencesReference Module Biomedical and Life Sciences