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Stem Cell Therapy

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Drug Discovery and Evaluation: Methods in Clinical Pharmacology

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Abstract

Stem cell therapy and regenerative medicine have a tremendous potential for the treatment of a wide variety of currently fatal diseases. So far, routine stem cell based therapies are limited to the treatment of hematologic and dermatologic malignancies, but the field is continuously evolving. One research focus lies on mesenchymal stem cells (MSCs) which have an immunomodulatory potential and support regenerative processes throughout the body. Pluripotent stem cells, on the other hand, can be differentiated into every cell type and might be able to replace damaged tissue in the future. Currently, stem cell based clinical trials are ongoing for a broad range of diseases affecting every organ, and the number of therapies that are obtaining approval, at least in certain countries, is continuously increasing. In this chapter we summarize the current state of research regarding stem cell based therapies. We introduce stem cell sources along with selected indications for their use and relevant clinical trials. We discuss options as well as limitations and risks of these treatments.

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  1. Institute for Stem Cell Research and Regenerative Medicine, Heinrich Heine University, Düsseldorf, Germany

    Nina Graffmann, Lucas-Sebastian Spitzhorn, Soraia Martins, Md Shaifur Rahman, Lisa Nguyen & James Adjaye

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  1. Nina Graffmann
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  2. Lucas-Sebastian Spitzhorn
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  3. Soraia Martins
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  4. Md Shaifur Rahman
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  5. Lisa Nguyen
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  6. James Adjaye
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Correspondence to James Adjaye .

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  1. CorDynamics, Dieburg, Germany

    Franz J. Hock

  2. CorDynamics, Chicago, IL, USA

    Michael R. Gralinski

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Graffmann, N., Spitzhorn, LS., Martins, S., Rahman, M.S., Nguyen, L., Adjaye, J. (2020). Stem Cell Therapy. In: Hock, F., Gralinski, M. (eds) Drug Discovery and Evaluation: Methods in Clinical Pharmacology. Springer, Cham. https://doi.org/10.1007/978-3-319-68864-0_72

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