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Multiple Iterative Seeding of Surface Plasmon Enhanced Cobalt-Iron Oxide Nanokernels for Cancer Theranostics

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Design and Evaluation of Plasmonic/Magnetic Au-MFe2O4 (M-Fe/Co/Mn) Core-Shell Nanoparticles Functionalized with Doxorubicin for Cancer Therapeutics

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Abstract

Cancer is the second leading disease which causes major mortality and morbidity worldwide [1]. In cancer therapy, it is crucial to increase the drug specificity and drug efficacy to minimize or completely eradicate significant side effects on patients [2]. Cancer nanotherapeutics overcome many serious drawbacks of chemotherapy such as nonspecific targeting, lower efficacy, insolubility of drug moieties in water, and oral bioavailability [3]. Accordingly, Superparamagnetic Iron Oxide Nanoparticles (SPIONs) are exploited as an important nanomaterial for cancer detection as well as therapeutics [4]. Such magnetic nanoparticles (NPs) gained its momentum because of their single-domain ordering along with their large surface-to-volume ratio (providing large surface area for attachment of biological entities). Hence, this property makes them a suitable candidate as a contrast agent, drug-carrying cargo, and hyperthermal agent [5]. The doping of SPIONs with cobalt ions further enhances their magnetic property, thus forming CoFe2O4 nanokernels (Nks). These spinel ferrite Nks possess ca. 20–30 times higher magneto-crystalline anisotropy as compared to SPIONs; this increases the performance of materials for biomedical applications [6–8]. Specifically, these Nks are mostly used in biomedicine than any other spinel structure because of their enhanced magnetic property and large anisotropy [9]. The increased superparamagnetism makes them an efficient system for theranostics [10–12].

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  1. Center for Research and Advanced Studies of the National Polytechnic Institute, Mexico City, Mexico

    Ravichandran Manisekaran

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Manisekaran, R. (2018). Multiple Iterative Seeding of Surface Plasmon Enhanced Cobalt-Iron Oxide Nanokernels for Cancer Theranostics. In: Design and Evaluation of Plasmonic/Magnetic Au-MFe2O4 (M-Fe/Co/Mn) Core-Shell Nanoparticles Functionalized with Doxorubicin for Cancer Therapeutics. Springer Theses. Springer, Cham. https://doi.org/10.1007/978-3-319-67609-8_5

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  • DOI: https://doi.org/10.1007/978-3-319-67609-8_5

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