Skip to main content

Abstract

Classification of emphysema patterns is believed to be useful for improved diagnosis and prognosis of chronic obstructive pulmonary disease. Emphysema patterns can be assessed visually on lung CT scans. Visual assessment is a complex and time-consuming task performed by experts, making it unsuitable for obtaining large amounts of labeled data. We investigate if visual assessment of emphysema can be framed as an image similarity task that does not require expert. Substituting untrained annotators for experts makes it possible to label data sets much faster and at a lower cost. We use crowd annotators to gather similarity triplets and use t-distributed stochastic triplet embedding to learn an embedding. The quality of the embedding is evaluated by predicting expert assessed emphysema patterns. We find that although performance varies due to low quality triplets and randomness in the embedding, we still achieve a median \(F_1\) score of 0.58 for prediction of four patterns.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Notes

  1. 1.

    https://www.mturk.com.

  2. 2.

    https://github.com/gcr/cython_tste.

  3. 3.

    https://cran.r-project.org/web/packages/nnet.

References

  1. Albarqouni, S., Baur, C., Achilles, F., Belagiannis, V., Demirci, S., Navab, N.: Aggnet: deep learning from crowds for mitosis detection in breast cancer histology images. IEEE TMI 35(5), 1313–1321 (2016)

    Google Scholar 

  2. Cheplygina, V., Perez-Rovira, A., Kuo, W., Tiddens, H.A.W.M., de Bruijne, M.: Early experiences with crowdsourcing airway annotations in chest CT. In: Carneiro, G., Mateus, D., Peter, L., Bradley, A., Tavares, J.M.R.S., Belagiannis, V., Papa, J.P., Nascimento, J.C., Loog, M., Lu, Z., Cardoso, J.S., Cornebise, J. (eds.) LABELS/DLMIA 2016. LNCS, vol. 10008, pp. 209–218. Springer, Cham (2016). doi:10.1007/978-3-319-46976-8_22

    Google Scholar 

  3. From the Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD) (2015)

    Google Scholar 

  4. Kovashka, A., Russakovsky, O., Fei-Fei, L., Grauman, K.: Crowdsourcing in computer vision. Found. Trends. Comput. Graph. Vis. 10(3), 177–243 (2016)

    Article  Google Scholar 

  5. Lo, P., Sporring, J., Ashraf, H., Pedersen, J.J.H.: Vessel-guided airway tree segmentation: a voxel classification approach. Med. Image Anal. 14(4), 527–538 (2010)

    Article  Google Scholar 

  6. Maier-Hein, L., Mersmann, S., Kondermann, D., Bodenstedt, S., Sanchez, A., Stock, C., Kenngott, H.G., Eisenmann, M., Speidel, S.: Can masses of non-experts train highly accurate image classifiers? In: Golland, P., Hata, N., Barillot, C., Hornegger, J., Howe, R. (eds.) MICCAI 2014. LNCS, vol. 8674, pp. 438–445. Springer, Cham (2014). doi:10.1007/978-3-319-10470-6_55

    Google Scholar 

  7. McFee, B., Lanckriet, G.: Learning multi-modal similarity. J. Mach. Learn. Res. 12, 491–523 (2011)

    MathSciNet  MATH  Google Scholar 

  8. Mitry, D., Zutis, K., Dhillon, B., Peto, T., Hayat, S., Khaw, K.-T., Morgan, J.E., Moncur, W., Trucco, E., Foster, P.J.: The accuracy and reliability of crowdsource annotations of digital retinal images. Trans. Vis. Sci. Technol. 5(5), 6–6 (2016)

    Article  Google Scholar 

  9. Nishio, M., Nakane, K., Kubo, T., Yakami, M., Emoto, Y., Nishio, M., Togashi, K.: Automated prediction of emphysema visual score using homology-based quantification of low-attenuation lung region. PLOS ONE 12(5), 1–12 (2017)

    Article  Google Scholar 

  10. Pedersen, J.H., Ashraf, H., Dirksen, A., Bach, K., Hansen, H., Toennesen, P., Thorsen, H., Brodersen, J., Skov, B.G., Døssing, M., Mortensen, J., Richter, K., Clementsen, P., Seersholm, N.: The Danish randomized lung cancer CT screening trial-overall design and results of the prevalence round. J. Thorac. Oncol. 4(5), 608–614 (2009)

    Article  Google Scholar 

  11. Nyboe Ørting, S., Petersen, J., Wille, M., Thomsen, L., de Bruijne, M.: Quantifying emphysema extent from weakly labeled CT scans of the lungs using label proportions learning. In: MICCAI PIA, pp. 31–42. CreateSpace Independent Publishing Platform (2016)

    Google Scholar 

  12. van der Maaten, L., Weinberger, K.: Stochastic triplet embedding. In: IEEE MLSP, pp. 1–6 (2012)

    Google Scholar 

  13. Wah, C., Van Horn, G., Branson, S., Maji, S., Perona, P., Belongie, S.: Similarity comparisons for interactive fine-grained categorization. In: IEEE CVPR, pp. 859–866 (2014)

    Google Scholar 

  14. Wille, M.M., Thomsen, L.H., Dirksen, A., Petersen, J., Pedersen, J.H., Shaker, S.B.: Emphysema progression is visually detectable in low-dose CT in continuous but not in former smokers. Eur. Radiol. 24(11), 2692–2699 (2014)

    Article  Google Scholar 

Download references

Acknowledgments

We would like to thank family, friends and coworkers at the University of Copenhagen, Erasmus MC - University Medical Center Rotterdam, Eindhoven University of Technology, and the start-up understand.ai for their help in testing prototype versions of the crowdsourcing tasks. This study was financially supported by the Danish Council for Independent Research (DFF) and the Netherlands Organization for Scientific Research (NWO).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Silas Nyboe Ørting .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing AG

About this paper

Cite this paper

Ørting, S.N., Cheplygina, V., Petersen, J., Thomsen, L.H., Wille, M.M.W., de Bruijne, M. (2017). Crowdsourced Emphysema Assessment. In: Cardoso, M., et al. Intravascular Imaging and Computer Assisted Stenting, and Large-Scale Annotation of Biomedical Data and Expert Label Synthesis. LABELS STENT CVII 2017 2017 2017. Lecture Notes in Computer Science(), vol 10552. Springer, Cham. https://doi.org/10.1007/978-3-319-67534-3_14

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-67534-3_14

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-67533-6

  • Online ISBN: 978-3-319-67534-3

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics