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Epithelial Barrier Function in Gut-Bone Signaling

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Understanding the Gut-Bone Signaling Axis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1033))

Abstract

The intestinal epithelial barrier plays an essential role in maintaining host homeostasis. The barrier regulates nutrient absorption as well as prevents the invasion of pathogenic bacteria in the host. It is composed of epithelial cells, tight junctions, and a mucus layer. Several factors, such as cytokines, diet, and diseases, can affect this barrier. These factors have been shown to increase intestinal permeability, inflammation, and translocation of pathogenic bacteria. In addition, dysregulation of the epithelial barrier can result in inflammatory diseases such as inflammatory bowel disease. Our lab and others have also shown that barrier disruption can have systemic effects including bone loss. In this chapter, we will discuss the current literature to understand the link between intestinal barrier and bone. We will discuss how inflammation, aging, dysbiosis, and metabolic diseases can affect intestinal barrier-bone link. In addition, we will highlight the current suggested mechanism between intestinal barrier and bone.

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Author notes

  1. Laura R. McCabe and Narayanan Parameswaran equally contributed to this work and are co-senior authors.

Authors and Affiliations

  1. Comparative Medicine and Integrative Biology Program, East Lansing, MI, USA

    Naiomy Deliz Rios-Arce & Narayanan Parameswaran

  2. Department of Physiology, Michigan State University, East Lansing, MI, USA

    Naiomy Deliz Rios-Arce, Fraser L. Collins, Jonathan D. Schepper, Michael D. Steury, Sandi Raehtz, Heather Mallin, Danny T. Schoenherr & Narayanan Parameswaran

  3. Department of Physiology and Department of Radiology, Biomedical Imaging Research Centre, Michigan State University, East Lansing, MI, USA

    Laura R. McCabe

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    Laura R. McCabe

  2. Comparative Medicine and Integrative Biology Program, East Lansing, Michigan, USA

    Narayanan Parameswaran

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Rios-Arce, N.D. et al. (2017). Epithelial Barrier Function in Gut-Bone Signaling. In: McCabe, L., Parameswaran, N. (eds) Understanding the Gut-Bone Signaling Axis. Advances in Experimental Medicine and Biology, vol 1033. Springer, Cham. https://doi.org/10.1007/978-3-319-66653-2_8

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