Abstract
One underlying contribution to aging-associated immune remodeling might be aging of the stem cell that all immune cells are derived from, the hematopoietic stem cell (HSC). A defined canonical set of phenotypic and functional features separates young from aged HSCs. Molecular mechanisms that contribute to aging of HSCs have been recently identified and comprise stem cell-intrinsic mechanisms as well as influences stemming from an aged stem cell niche. Aging of stem cells is reversible, and rejuvenation of aged HSCs might contribute to healthy aging.
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Leins, H., Geiger, H. (2018). Lymphohematopoietic Stem Cells and Their Aging. In: Fulop, T., Franceschi, C., Hirokawa, K., Pawelec, G. (eds) Handbook of Immunosenescence. Springer, Cham. https://doi.org/10.1007/978-3-319-64597-1_30-1
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DOI: https://doi.org/10.1007/978-3-319-64597-1_30-1
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