Abstract
Sorghum bicolor is the fifth most important cereal crop in the world after rice, wheat, barley and maize and is grown worldwide in the semi-arid and arid regions. Functional identification of proteins and a detailed study of protein-protein interactions in Sorghum are very essential to understand the biological process underlying the various traits of crops such as salt stress, yield and drought response. The molecular mechanisms that exists among them are still unclear due to the limited studies available in the literature and databases. In this paper, salt stress tolerance responsive protein-protein interaction network has been constructed using STRING database. A comprehensive bioinformatics analysis of this network has been performed using Cytoscape, through the computation of centrality measures and functional enrichment study. This study has resulted in the identification of Sb02g023480.1, Sb01g040040.1, Sb09g027910.1, Sb03g031310.1, Sb10g002460.1 as salt stress tolerant proteins in Sorghum bicolor. However, experimental studies are required to confirm this observation.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Barabasi, A.L., Zoltan, N.O.: Network biology: understanding the cell’s functional organization. Nat. Rev. Genet. 5(2), 101–113 (2004)
Bhattacharyya, M., Saikat, C.: Identification of important interacting proteins (IIPs) in Plasmodium falciparum using large-scale interaction network analysis and in-silico knock-out studies. Malaria J. 14, 1–17 (2015)
Brewis, I.A., Brennan, P.: Proteomics technologies for the global identification and quantification of proteins. Adv. Protein Chem. Struct. Biol. 80(15), 1–44 (2010)
Deng, M., Zhang, K., Mehta, S., Chen, T., Sun, F.: Prediction of protein function using protein-protein interaction data. J. Comput. Biol. 10(6), 947–960 (2003)
El-Omari, R., Nhiri, M.: Adaptive response to salt stress in sorghum (Sorghum bicolor). Am.-Eur. J. Agric. Environ. Sci. 15(7), 1351–1360 (2015)
Jiang, Y., Yang, B., Harris, N.S., Deyholos, M.K.: Comparative proteomic analysis of NaCl stress-responsive proteins in Arabidopsis roots. J. Exp. Bot. 58(13), 359–3607 (2007)
Karabekmez, M.E., Betul, K.: A novel topological centrality measure capturing biologically important proteins. Mol. BioSyst. 12(2), 666–673 (2016)
Kasuga, M., Qiang, L., Setsuko, M., Kazuko, Y.S., Kazuo, S.: Improving plant drought, salt, and freezing tolerance by gene transfer of a single stress-inducible transcription factor. Nat. Biotechnol. 17(3), 287–291 (1999)
Neumann, P.M., Azaizeh, H., Leon, D.: Hardening of root cell walls: a growth inhibitory response to salinity stress. Plant Cell Environ. 17(3), 303–309 (1994)
Rai, K.N., Murty, D.S., Andrews, D.J., Bramel-Cox, P.J.: Genetic enhancement of pearl millet and sorghum for the semi-arid tropics of Asia and Africa. Genome. 42(4), 617–628 (1999)
Scardoni, G., Michele, P., Carlo, L.: Analyzing biological network parameters with CentiScaPe. Bioinformatics 25(21), 2857–2859 (2009)
Shannon, P., Markiel, A., Ozier, O., Baliga, N.S., Wang, J.T., Ramage, D., Amin, N., Schwikowski, B., Ideker, T.: Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 13(11), 2498–2504 (2003)
Shinozaki, K., Kazuko, Y.S., Motoaki, S.: Regulatory network of gene expression in the drought and cold stress responses. Curr. Opin. Plant Biol. 6(5), 410–417 (2003)
Steudle, E.: Water uptake by roots: effects of water deficit. J. Exp. Bot. 51, 1531–1542 (2000)
Tanga, Y., Lia, M., Wanga, J., Pana, Y., Wu, F.X.: CytoNCA: a cytoscape plugin for centrality analysis and evaluation of protein interaction networks. Biosystems. 127, 67–72 (2015)
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2017 Springer International Publishing AG
About this paper
Cite this paper
Rajeswari, S., Indhumathy, M., Somasundaram, A., Sood, N., Arumugam, S. (2017). Identification of Salinity Stress Tolerant Proteins in Sorghum Bicolor Computational Approach. In: Arumugam, S., Bagga, J., Beineke, L., Panda, B. (eds) Theoretical Computer Science and Discrete Mathematics. ICTCSDM 2016. Lecture Notes in Computer Science(), vol 10398. Springer, Cham. https://doi.org/10.1007/978-3-319-64419-6_41
Download citation
DOI: https://doi.org/10.1007/978-3-319-64419-6_41
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-64418-9
Online ISBN: 978-3-319-64419-6
eBook Packages: Computer ScienceComputer Science (R0)