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The Effect of Menopause and HRT on Coronary Heart Disease

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Pre-Menopause, Menopause and Beyond

Part of the book series: ISGE Series ((ISGE))

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Abstract

Loss of ovarian function at the menopause results in adverse metabolic and vascular changes that increase the risk for coronary heart disease (CHD). Hormone replacement therapy (HRT) will reverse many of these changes, although this will be dependent on the type of hormones used, the dose of hormones at initiation of treatment, and in some cases the route of administration. Many observational studies have shown the association between postmenopausal HRT use and reduced incidence of CHD, and there is now increasing randomised clinical trial evidence to support this benefit. Given appropriately, HRT has the potential to be a major therapy for prevention of CHD in postmenopausal women.

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Author information

Authors and Affiliations

  1. National Heart and Lung Institute, Imperial College London, Royal Brompton Hospital, London, SW3 6NP, UK

    John C. Stevenson

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  1. John C. Stevenson
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Correspondence to John C. Stevenson .

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Editors and Affiliations

  1. Professor emeritus for Gynaecological Endocrinology and Reproductive Medicine, University of Bern, Bern, Switzerland

    Martin Birkhaeuser

  2. International Society of Gynecological Endocrinology, Pisa, Italy

    Andrea R. Genazzani

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© 2018 International Society of Gynecological Endocrinology

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Stevenson, J.C. (2018). The Effect of Menopause and HRT on Coronary Heart Disease. In: Birkhaeuser, M., Genazzani, A. (eds) Pre-Menopause, Menopause and Beyond. ISGE Series. Springer, Cham. https://doi.org/10.1007/978-3-319-63540-8_15

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  • DOI: https://doi.org/10.1007/978-3-319-63540-8_15

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-63539-2

  • Online ISBN: 978-3-319-63540-8

  • eBook Packages: MedicineMedicine (R0)

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