Abstract
Maternal metabolic diseases such as diabetes mellitus with diabetogenic hypoinsulinemia and hyperglycemia change periconceptional developmental conditions in utero. In preimplantation rabbit embryos, all major metabolic pathways are affected. Alterations in protein, lipid and glucose metabolism, adipokines, advanced glycation end products (AGEs) and reactive oxygen species (ROS) are described in this review. The embryonic metabolism is characterized by a high plasticity which enables survival of most preimplantation embryos under the non-physiological developmental conditions in diabetic mothers. Adiponectin, for example, compensates for the missing insulin-driven glucose supply and stimulates intracellular lipid accumulation in embryonic cells. AGEs and ROS are clear indicators of metabolic stress. The price paid for survival, however, needs to be taken into consideration. It is an increase in lipogenesis and proteinogenesis, leading to metabolic stress and with potentially negative long-term health effects.
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Acknowledgements
The work described was funded by EU (FP7-EpiHealth (No. 278418), EpiHealthNet (No. 317146), Cost Actions TD 1101 (RGB-Net), FA1201 (EPICONCEPT) and BM 1308 (SALAAM)), the Wilhelm Roux Programme of the MLU Faculty of Medicine and the German Research Council (DFG (NA 418/4-2)).
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Fischer, B. et al. (2017). The Long-Term Effect of the Periconception Period on the Embryo’s Epigenetic Profile and Phenotype: The Role of Maternal Disease Such as Diabetes and How the Effect Is Mediated (Example from a Rabbit Model). In: Fazeli, A., Holt, W. (eds) Periconception in Physiology and Medicine. Advances in Experimental Medicine and Biology, vol 1014. Springer, Cham. https://doi.org/10.1007/978-3-319-62414-3_6
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DOI: https://doi.org/10.1007/978-3-319-62414-3_6
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