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Tissue Bioengineering in Transplantation

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Technological Advances in Organ Transplantation

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Abstract

Organ transplantation has emerged in recent decades as one of the most effective modalities for the treatment of end-stage organ disease. Over 100,000 transplants are performed worldwide each year; however, the supply has not been able to keep up with increasing demand. Furthermore, transplant recipients are committed to a lifelong regimen of brutal immunosuppressive medications that themselves carry significant side effect profiles, influencing clinical outcomes. Recent advances in the fields of tissue engineering and regenerative medicine are beginning to offer alternative solutions that could potentially improve the longevity, functionality, and biocompatibility profiles of transplants. Decellularization technology to produce extracellular matrix scaffolds represents one of the most promising strategies currently under investigation. Such methods can produce bioengineered, transplantable organs using autologous cells that would bypass the need for immunosuppression and its associated side effects. Furthermore, bioengineering strategies in general are not bound by supply constraints imposed by organ donation.

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Abbreviations

ECM:

Extracellular matrix

ESC:

Embryonic stem cell

iPSC:

Induced pluripotent stem cell

MSC:

Mesenchymal stem cell

PEG:

Polyethylene glycol

TE:

Tissue engineering

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Authors and Affiliations

  1. Wake Forest School of Medicine, Winston Salem, NC, USA

    Ravi Katari, Lauren Edgar, Kevin Enck & Riccardo Tamburrini

  2. General Surgery, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy

    Andrea Peloso

  3. Department of Surgery, Section of Transplantation, Wake Forest School of Medicine, Winston Salem, NC, USA

    Giuseppe Orlando MD, PhD

  4. Wake Forest Baptist Hospital, Medical Center Blvd, Winston Salem, NC, 27157, USA

    Giuseppe Orlando MD, PhD

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  1. Ravi Katari
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  1. Medical University of South Carolina, Charleston, South Carolina, USA

    Satish N. Nadig

  2. Northwestern University, Chicago, Illinois, USA

    Jason A. Wertheim

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Katari, R., Edgar, L., Enck, K., Peloso, A., Tamburrini, R., Orlando, G. (2017). Tissue Bioengineering in Transplantation. In: Nadig, S., Wertheim, J. (eds) Technological Advances in Organ Transplantation. Springer, Cham. https://doi.org/10.1007/978-3-319-62142-5_8

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