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Clinical Neuroradiology pp 1–17Cite as

Neuroimaging in Normal Brain Aging

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Abstract

In the evaluation of age-related neurological diseases in clinical neuroradiology, knowledge on the background of “normal” brain aging and its associated changes is important but often overlooked. Radiological techniques applied to assess neurodegeneration will also show a variety brain changes that may be part of the “normal” aging spectrum, such as brain atrophy, white matter hyperintensities, silent brain infarcts, cerebral microbleeds, enlarged perivascular spaces, and iron accumulation. This chapter describes typical structural brain changes seen on imaging studies in “normal” aging and includes practical guidelines for application in daily clinical neuroradiology practice to identify abnormality.

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Author information

Authors and Affiliations

  1. Department of Epidemiology, Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands

    Meike W. Vernooij

  2. Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands

    Frederik Barkhof

  3. Department of Neuroradiology, University College London, Institute of Neurology, London, UK

    Frederik Barkhof

Authors
  1. Meike W. Vernooij
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  2. Frederik Barkhof
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Corresponding author

Correspondence to Meike W. Vernooij .

Editor information

Editors and Affiliations

  1. Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands

    Frederik Barkhof

  2. National Hosp.f Neurology & Neurosurgery, UCL National Hosp.f Neurology & Neurosurgery, London, United Kingdom

    Rolf Jager

  3. Division of Neuroradiology, University Hospital Vienna Division of Neuroradiology, Wien, Austria

    Majda Thurnher

  4. Department of Neuroradiology, Hospital Vall d’Hebrón Department of Neuroradiology, Barcelona, Spain

    Alex Rovira Cañellas

Section Editor information

  1. Affidea, Geneva, Switzerland

    Sven Haller

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Vernooij, M.W., Barkhof, F. (2018). Neuroimaging in Normal Brain Aging. In: Barkhof, F., Jager, R., Thurnher, M., Rovira Cañellas, A. (eds) Clinical Neuroradiology. Springer, Cham. https://doi.org/10.1007/978-3-319-61423-6_63-1

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  • DOI: https://doi.org/10.1007/978-3-319-61423-6_63-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-61423-6

  • Online ISBN: 978-3-319-61423-6

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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