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The Cellular and Molecular Mechanisms of Hematopoiesis

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Bone Marrow Failure

Part of the book series: Pediatric Oncology ((PEDIATRICO))

Abstract

Hematopoiesis is a complex and dynamic process where mature blood cells of the myeloid and lymphoid lineages are produced from a common hematopoietic progenitor cell. In adult mammals, this process occurs within the bone marrow where hematopoietic progenitors integrate signals and cues from the microenvironment to activate gene expression programs that control lineage specification and maturation. In this chapter, we will review the cellular intrinsic and extrinsic factors that contribute to the regulation of hematopoiesis in the adult bone marrow.

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Authors and Affiliations

  1. Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA

    Erinn B. Rankin

  2. Department of Obstetrics and Gynecologic Oncology, Stanford University School of Medicine, Stanford, CA, USA

    Erinn B. Rankin

  3. Division of Hematology/Oncology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA

    Kathleen M. Sakamoto

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  1. Erinn B. Rankin
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  2. Kathleen M. Sakamoto
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Correspondence to Kathleen M. Sakamoto .

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  1. Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA

    Gary M. Kupfer

  2. Department of Pediatrics, George Washington University, Washington, DC, USA

    Gregory H. Reaman

  3. Medpace, Cincinnati, OH, USA

    Franklin O. Smith

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Rankin, E.B., Sakamoto, K.M. (2018). The Cellular and Molecular Mechanisms of Hematopoiesis. In: Kupfer, G., Reaman, G., Smith, F. (eds) Bone Marrow Failure. Pediatric Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-61421-2_1

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