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Teratogenic Influences on Cerebellar Development

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Development of the Cerebellum from Molecular Aspects to Diseases

Part of the book series: Contemporary Clinical Neuroscience ((CCNE))

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Abstract

The effects of environmental agents on cerebellar development are profound, and this organ has not been given the attention that is deserving of it, based on its importance in motor, cognitive, and behavioral functions. This chapter will review select agents associated with teratogenic effects on cerebellar structure and function. Mechanisms of teratogenesis and genetic influences will be addressed. The emerging role of effects of environmental agents and effect on the epigenetic mechanisms and gene expression are discussed. Prenatal alcohol exposure and fetal alcohol spectrum disorder will be discussed in greater detail, as this disorder is the most common teratogenic disorder affecting humans. Indeed, many of the phenotypic effects of FASD are the result of cerebellar injury and dysfunction.

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  1. Departments of Paediatrics and Child Health and Biochemistry and Medical Genetics, Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Manitoba, Canada

    Albert E. Chudley MD

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  1. Department of Human Anatomy and Cell Science, The Children’s Hospital Research Institute of Manitoba (CHRIM), Max Rady College of Medicine, Rady Faculty of Health Science, University of Manitoba, Winnipeg, MB, Canada

    Hassan Marzban

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Chudley, A.E. (2017). Teratogenic Influences on Cerebellar Development. In: Marzban, H. (eds) Development of the Cerebellum from Molecular Aspects to Diseases. Contemporary Clinical Neuroscience. Springer, Cham. https://doi.org/10.1007/978-3-319-59749-2_14

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