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Store-Operated Ca²⁺ Entry (SOCE) Pathways pp 217–237Cite as

New Aspects of the Contribution of ER to SOCE Regulation: The Role of the ER and ER-Plasma Membrane Junctions in the Regulation of SOCE

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 993))

Abstract

The junctions between the endoplasmic reticulum and the plasma membrane are essential platforms for the activation of store-operated Ca2+ influx. These junctions have specific dimensions and are nonuniformly distributed in polarized cells. The mechanisms involved in the formation of the junctions are currently undergoing vigorous investigation, and significant progress was attained in this research area during the last 10 years. Some cell types display stationary junctions, while in other cells, new junctions can form rapidly following cytosolic Ca2+ signals and/or the reduction of the Ca2+ concentration in the lumen of the endoplasmic reticulum; furthermore, in moving cells, junctions can undergo saltatory formation, long distance sliding, and dissolution. The proteins involved in the activation of the Ca2+ influx could be also involved in the formation of the junctions. The architecture, dynamics, and localization of the junctions are important for the regulation of Ca2+ signaling cascades and their downstream events.

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Authors and Affiliations

  1. School of Biosciences, Cardiff University, Cardiff, UK

    Hayley Dingsdale

  2. The Physiological Laboratory, Department of Cellular and Molecular Physiology, Institute of Translational Medicine, The University of Liverpool, Crown Street, Liverpool, L69 3BX, UK

    Emmanuel Okeke, Lee Haynes & Alexei V. Tepikin

  3. Department of Neurobiology, Yale School of Medicine, New Haven, CT, USA

    Gyorgy Lur

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  1. Hayley Dingsdale
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  2. Emmanuel Okeke
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  3. Lee Haynes
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  4. Gyorgy Lur
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  5. Alexei V. Tepikin
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Correspondence to Hayley Dingsdale or Alexei V. Tepikin .

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  1. Institute of Biophysics, Medical University of Graz, Graz, Austria

    Klaus Groschner

  2. Institute of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria

    Wolfgang F. Graier

  3. Institute of Biophysics, Johannes Kepler University Linz, Linz, Austria

    Christoph Romanin

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Dingsdale, H., Okeke, E., Haynes, L., Lur, G., Tepikin, A.V. (2017). New Aspects of the Contribution of ER to SOCE Regulation: The Role of the ER and ER-Plasma Membrane Junctions in the Regulation of SOCE. In: Groschner, K., Graier, W., Romanin, C. (eds) Store-Operated Ca²⁺ Entry (SOCE) Pathways. Advances in Experimental Medicine and Biology, vol 993. Springer, Cham. https://doi.org/10.1007/978-3-319-57732-6_12

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