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Tamoxifen: An Update

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Hysteroscopy

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Abstract

Tamoxifen is a selective estrogen receptor modulator (SERM). These agents act as competitive inhibitors of estrogens, binding to estrogen receptors (ERs) and, depending on the tissue of action, having an agonist or antagonist effect on these receptors. The mechanism of action and main effects of tamoxifen on endometrium will be reviewed in this chapter. Tamoxifen has shown to slightly increase the risk of atypical endometrial lesions, which can be diagnosed with hysteroscopy. An optimal baseline evaluation and follow-up of patients treated with tamoxifen, in order to diagnose and treat these lesions has not been established.

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Author information

Authors and Affiliations

  1. Diagnostic—Surgical Hysteroscopy Unit, Obstetrics and Gynecology Service, Hospital 12 October, School of Medicine, Complutense University, Avda Cordoba s/n 28041, Madrid, Spain

    Jesus S. Jimenez M.D., Ph.D., Alvaro Diez M.D. & Alejandro Olloqui M.D.

Authors
  1. Jesus S. Jimenez M.D., Ph.D.
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  2. Alvaro Diez M.D.
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  3. Alejandro Olloqui M.D.
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Corresponding author

Correspondence to Jesus S. Jimenez M.D., Ph.D. .

Editor information

Editors and Affiliations

  1. Department of Obstetrics and Gynaecology, Ospedale Vito Fazzi, Lecce, Italy

    Andrea Tinelli

  2. Hysteroscopy Unit, Gutenberg Institute, Malaga, Spain

    Luis Alonso Pacheco

  3. Hysteroscopy Unit, Hospital Del Mar, Barcelona, Spain

    Sergio Haimovich

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Jimenez, J.S., Diez, A., Olloqui, A. (2018). Tamoxifen: An Update. In: Tinelli, A., Alonso Pacheco, L., Haimovich, S. (eds) Hysteroscopy. Springer, Cham. https://doi.org/10.1007/978-3-319-57559-9_30

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  • DOI: https://doi.org/10.1007/978-3-319-57559-9_30

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  • Publisher Name: Springer, Cham

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  • Online ISBN: 978-3-319-57559-9

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