Skip to main content

Hysteroscopy in Patients with Repeated Implantation Failure

  • Chapter
  • First Online:
Hysteroscopy
  • 2484 Accesses

Abstract

Repeated implantation failure is a major clinical challenge and is the cause of considerable stress to patients and clinicians in assisted reproductive technology (ART). Hysteroscopy enables the clinician evaluate the uterine abnormalities such as endometrial polyps, submucous myomas, adhesions, septa, tubal ostia, and inflammatory endometrial pathologies like endometrial tuberculosis and chronic endometritis. Hysteroscopy also allows the diagnosis as well as the treatment of the intrauterine pathology in the same setting, thereby increasing the pregnancy rate in subfertility.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

References

  1. Bouwmans CA, Lintsen BM, Eijkemans MJ, Habbema JD, Braat DD, Hakkaart L. A detailed cost analysis of in vitro fertilization and intracytoplasmic sperm injection treatment. Fertil Steril. 2008;89(2):331–41.

    Article  PubMed  Google Scholar 

  2. Rogers PA, Milne BJ, Trounson AO. A model to show human uterine receptivity and embryo viability following ovarian stimulation for in vitro fertilization. J In Vitro Fert Embryo Transf. 1986;3(2):93–8.

    Article  CAS  PubMed  Google Scholar 

  3. Shamma FN, Lee G, Gutmann JN, Lavy G. The role of office hysteroscopy in in vitro fertilization. Fertil Steril. 1992;58(6):1237–9.

    Article  CAS  PubMed  Google Scholar 

  4. La Sala GB, Montanari R, Dessanti L, Cigarini C, Sartori F. The role of diagnostic hysteroscopy and endometrial biopsy in assisted reproductive technologies. Fertil Steril. 1998;70(2):378–80.

    Article  PubMed  Google Scholar 

  5. Oliveira FG, Abdelmassih VG, Diamond MP, Dozortsev D, Nagy ZP, Abdelmassih R. Uterine cavity findings and hysteroscopic interventions in patients undergoing in vitro fertilizationembryo transfer who repeatedly cannot conceive. Fertil Steril. 2003;80(6):1371–5.

    Article  PubMed  Google Scholar 

  6. Hinckley MD, Milki AA. 1000 officebased hysteroscopies prior to in vitro fertilization: feasibility and findings. JSLS. 2004;8(2):103–7.

    PubMed  PubMed Central  Google Scholar 

  7. Demirol A, Gurgan T. Effect of treatment of intrauterine pathologies with office hysteroscopy in patients with recurrent IVF failure. Reprod Biomed Online. 2004;8(5):590–4.

    Article  PubMed  Google Scholar 

  8. Doldi N, Persico P, Di Sebastiano F, Marsiglio E, De Santis L, Rabellotti E, Fusi F, Brigante C, Ferrari A. Pathologic findings in hysteroscopy before in vitro fertilizationembryo transfer (IVFET). Gynecol Endocrinol. 2005;21(4):235–7.

    Article  PubMed  Google Scholar 

  9. Rama Raju GA, Shashi Kumari G, Krishna KM, Prakash GJ, Madan K. Assessment of uterine cavity by hysteroscopy in assisted reproduction programme and its influence on pregnancy outcome. Arch Gynecol Obstet. 2006;274(3):160–4.

    Article  CAS  PubMed  Google Scholar 

  10. Bosteels J, Weyers S, Puttemans P, Panayotidis C, Van Herendael B, Gomel V, Mol BW, Mathieu C, D'Hooghe T. The effectiveness of hysteroscopy in improving pregnancy rates in subfertile women without other gynaecological symptoms: a systematic review. Hum Reprod Update. 2010;16(1):1–11.

    Article  PubMed  Google Scholar 

  11. Fatemi HM, Kasius JC, Timmermans A, van Disseldorp J, Fauser BC, Devroey P, Broekmans FJ. Prevalence of unsuspected uterine cavity abnormalities diagnosed by office hysteroscopy prior to in vitro fertilization. Hum Reprod. 2010;25(8):1959–65.

    Article  CAS  PubMed  Google Scholar 

  12. ElMazny A, AbouSalem N, ElSherbiny W, Saber W. Outpatient hysteroscopy: a routine investigation before assisted reproductive techniques? Fertil Steril. 2011;95(1):272–6.

    Article  Google Scholar 

  13. Makrakis E, Pantos K. The outcomes of hysteroscopy in women with implantation failures after invitro fertilization: findings and effect on subsequent pregnancy rates. Curr Opin Obstet Gynecol. 2010;22(4):339–43.

    PubMed  Google Scholar 

  14. Crosignani PG, Rubin BL. Optimal use of infertility diagnostic tests and treatments, The ESHRE Capri Workshop Group. Hum Reprod. 2000;15(3):723–32.

    Article  CAS  PubMed  Google Scholar 

  15. Smit JG, Kasius JC, Eijkemans MJ, Koks CA, Van Golde R, Oosterhuis JG, Nap AW, Scheffer GJ, Manger PA, Hoek A, Kaplan M, Schoot DB, van Heusden AM, Kuchenbecker WK, Perquin DA, Fleischer K, Kaaijk EM, Sluijmer A, Friederich J, Laven JS, van Hooff M, Louwe LA, Kwee J, Boomgaard JJ, de Koning CH, Janssen IC, Mol F, Mol BW, Torrance HL, Broekmans FJ. The inSIGHT study: costs and effects of routine hysteroscopy prior to a first IVF treatment cycle. A randomised controlled trial. BMC Womens Health. 2012;12:22.

    Article  PubMed  PubMed Central  Google Scholar 

  16. National Collaborating Centre for Women’s and Children’s Health (UK). Fertility: assessment and treatment for people with fertility problems. London, UK: RCOG Press; 2004. NICE Clinical Guidelines, No. 11. Available from: https://www.ncbi.nlm.nih.gov/books/NBK45935

    Google Scholar 

  17. Gera PS, Allemand MC, Tatpati LL, Galanits TM, Morbeck D, Coddington CC. Role of saline infusion sonography in uterine evaluation before frozen embryo transfer cycle. Fertil Steril. 2008;89(3):562–6.

    Article  PubMed  Google Scholar 

  18. Bosteels J, Kasius J, Weyers S, Broekmans FJ, Mol BW, D'Hooghe TM. Hysteroscopy for treating subfertility associated with suspected major uterine cavity abnormalities. Cochrane Database Syst Rev. 2015;(2).

    Google Scholar 

  19. Bozdag G, Aksan G, Esinler I, Yarali H. What is the role of office hysteroscopy in women with failed IVF cycles? Reprod Biomed Online. 2008;17(3):410–5.

    Article  PubMed  Google Scholar 

  20. Cenksoy P, Ficicioglu C, Yıldırım G, Yesiladali M. Hysteroscopic findings in women with recurrent IVF failures and the effect of correction of hysteroscopic findings on subsequent pregnancy rates. Arch Gynecol Obstet. 2013;287(2):357–60.

    Article  PubMed  Google Scholar 

  21. Woelfer B, Salim R, Banerjee S, Elson J, Regan L, Jurkovic D. Reproductive outcomes in women with congenital uterine anomalies detected by three-dimensional ultrasound screening. Obstet Gynecol. 2001;98(6):1099–103.

    CAS  PubMed  Google Scholar 

  22. Propst AM, Hill JA. Anatomic factors associated with recurrent pregnancy loss. Semin Reprod Med. 2000;18(4):341–50.

    Article  CAS  PubMed  Google Scholar 

  23. Creasy RK, Resnik R. Maternal-fetal medicine: principles and practice. Philadelphia: W.B. Saunders; 1994. p. 447.

    Google Scholar 

  24. Buttram VC, Gibbons WE. Mullerian anomalies: a proposed classification. (An analysis of 144 cases). Fertil Steril. 1979;32(1):40–6.

    Article  PubMed  Google Scholar 

  25. Tripathy SN, Tripathy SN. Endometrial tuberculosis. J Indian Med Assoc. 1987;85(5):136–40.

    CAS  PubMed  Google Scholar 

  26. Schaefer G. Female genital tuberculosis. Clin Obstet Gynecol. 1976;19(1):223–39.

    Article  CAS  PubMed  Google Scholar 

  27. Siegler AM, Kontppoulous V. Female genital tuberculosis and the role of hysterosalpingography. Semin Roentgenol. 1979;14:295.

    Article  CAS  PubMed  Google Scholar 

  28. Kumar A, Kumar A. Endometrial tuberculosis. J Am Assoc Gynecol Laparosc. 2004;11(1):2.

    Article  PubMed  Google Scholar 

  29. Kumar A, Kumar A. Unusual appearing tubercular deposits at hysteroscopy. J Minim Invasive Gynecol. 2007;14(2):144.

    Article  PubMed  Google Scholar 

  30. Kumar A, Kumar A. Intraluminal tubal adhesions. Fertil Steril. 2008;89(2):434–5.

    Article  PubMed  Google Scholar 

  31. Kumar A, Kumar A. Hysteroscopic findings of starry sky appearance and impregnated cobwebs in endometrial tuberculosis. Int J Gynaecol Obstet. 2014;126(3):280–1.

    Article  PubMed  Google Scholar 

  32. Kumar A, Kumar A. Relook hysteroscopy after antitubercular therapy. Fertil Steril. 2008;89(3):701–2.

    Article  PubMed  Google Scholar 

  33. Kumar A, Kumar A. Surface architecture in endometrial tuberculosis. J Minim Invasive Gynecol. 2014;21(5):727–8.

    Article  PubMed  Google Scholar 

  34. Kumar A, Kumar A. Endometrial tuberculosis in a unicornuate uterus with a rudimentary horn. J Minim Invasive Gynecol. 2007;14(3):269.

    Article  PubMed  Google Scholar 

  35. Cicinelli E, Tinelli R, Colafiglio G, Saliani N, Pastore A. Tubercular endometritis: a rare condition reliably detectable with fluid hysteroscopy. J Minim Invasive Gynecol. 2008;15(6):752–4.

    Article  PubMed  Google Scholar 

  36. Sherman ME, Mazur MT, Kurman RJ. Benign diseases of the endometrium. In: Kurman RJ, editor. Blaustein’s pathology of the female genital tract. New York: Springer; 2002. p. 180.

    Google Scholar 

  37. Cravello L, et al. Identification and treatment of endometritis. Contracept Fertil Sex. 1997;25:585–6.

    CAS  PubMed  Google Scholar 

  38. Greenwood SM, Moran JJ. Chronic endometritis: morphologic and clinical observations. Obstet Gynecol. 1981;58(2):176–84.

    CAS  PubMed  Google Scholar 

  39. Cicinelli E, Resta L, Nicoletti R, Tartagni M, Marinaccio M, Bulletti C, Colafiglio G. Detection of chronic endometritis at fluid hysteroscopy. J Minim Invasive Gynecol. 2005;12(6):514–8.

    Article  PubMed  Google Scholar 

  40. Hamou JE. Microhysteroscopic appearances. In: Hamou JE, Taylor PJ, editors. Hysteroscopy and microcolpohysteroscopy: a text and atlas. Norwalk, CT: Appleton & Lange; 1991. p. 134.

    Google Scholar 

  41. Dotto JE, et al. Classification of microhysteroscopic images and their correlation with histologic diagnoses. J Am Assoc Gynecol Laparosc. 2003;10:233–46.

    Article  PubMed  Google Scholar 

  42. Kumar A, Kumar A. An unusual appearance chronic Endometritis. J Minim Invasive Gynecol. 2015;22(6):927–8.

    Article  PubMed  Google Scholar 

  43. Kumar A, Kumar A. A successful break up. Am J Obstet Gynecol. 2007;197(6):685.e1–2.

    Article  Google Scholar 

  44. Kodman PH. Hysteroscopic polypectomy undergoing IVF treatment for women when is it necessary? Curr Opin Obstet Gynecol. 2016;28:184–90.

    Article  Google Scholar 

  45. Weimar CH, Macklon NS, Post Uiterweer ED, Brosens JJ, Gellersen B. The motile and invasive capacity of human endometrial stromal cells: implications for normal and impaired reproductive function. Hum Reprod Update. 2013;19(5):542–57.

    Article  CAS  PubMed  Google Scholar 

  46. Grimbizis GF, Mikos T, Tarlatzis B. Uterus-sparing operative treatment for adenomyosis. Fertil Steril. 2014;101(2):472–87.

    Article  PubMed  Google Scholar 

  47. Seval MM, Şükür YE, Özmen B, Kan Ö, Sönmezer M, Berker B, Atabekoğlu C. Does adding endometrial scratching to diagnostic hysteroscopy improve pregnancy rates in women with recurrent in-vitro fertilization failure? Gynecol Endocrinol. 2016;32(12):957–60.

    Article  PubMed  Google Scholar 

  48. ElKhayat W, Elsadek M, Saber W. Comparing the effect of office hysteroscopy with endometrial scratch versus office hysteroscopy on intrauterine insemination outcome: a randomized controlled trial. Eur J Obstet Gynecol Reprod Biol. 2015;194:96–100.

    Article  Google Scholar 

  49. Lensen SF, Manders M, Nastri CO, Gibreel A, Martins WP, Templer GE, Farquhar C. Endometrial injury for pregnancy following sexual intercourse or intrauterine insemination. Cochrane Database Syst Rev. 2016;(6):CD01142.

    Google Scholar 

  50. Potdar N, Gelbaya T, Nardo LG. Endometrial injury to overcome recurrent embryo implantation failure: a systematic review and metaanalysis. Reprod Biomed Online. 2012;25(6):561–71.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Alka Kumar M.B.B.S., M.S. .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG

About this chapter

Cite this chapter

Kumar, A. (2018). Hysteroscopy in Patients with Repeated Implantation Failure. In: Tinelli, A., Alonso Pacheco, L., Haimovich, S. (eds) Hysteroscopy. Springer, Cham. https://doi.org/10.1007/978-3-319-57559-9_21

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-57559-9_21

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-57558-2

  • Online ISBN: 978-3-319-57559-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics