Abstract
This chapter outlines the anatomy, clinical presentation, and relevant clinical investigations. Details of both non-neoplastic and neoplastic pathological conditions affecting lymph nodes, spleen and bone marrow are given. Clinical considerations in obtaining the diagnostic biopsy and therapeutic resection specimens are outlined, with details of their handling and dissection in the histopathology laboratory. This is correlated with relevant histopathology reports, giving summary of core prognostic and patient management items. Current WHO and TNM classifications are referenced.
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Bibliography
Adamson JW, Longo DL. Anaemia and polycythemia.
Alizadeh AA, Eisen MB, Davis RE. Distinct types of large B-cell lymphoma identified by gene expression profiling. Nature. 2000;403:503–11.
Allen DC. Histopathology reporting. Guidelines for surgical cancer. 3rd ed. London: Springer; 2013.
Allen DC, Cameron RI. Histopathology specimens: clinical, pathological and laboratory aspects. 2nd ed. Berlin-Heidelberg: Springer; 2013.
Arber DA, Orazi A, Hasserjian R, Thiele J, Borowitz MJ, Le Beau MM, Bloomfield CD, Cazzola M, Vardiman JW. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood. 2016;127:2391–405.
Brown D, Gatter K, Natkunam Y. Bone marrow diagnosis: an illustrated guide. Oxford: Wiley Blackwell; 2006.
Brunning RD, Arber DA. Chapter 23: Bone marrow. In: Rosai J, editor. Rosai and Ackerman’s surgical pathology. 10th ed. St. Louis: Elsevier; 2011.
Chan JKC. Tumours of the lymphoreticular system, including spleen and thymus. In: Fletcher CDM, editor. Diagnostic histopathology of tumours, vol. 2. 3rd ed. London: Harcourt; 2007. p. 1139–310.
Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson JL, editors. Harrison’s principles of internal medicine, vol. 1. 18th ed. New York: McGraw-Hill; 2011. p. 450–71.
Hall JG. The functional anatomy of lymph nodes. In: Stansfield AG, d’ Ardenne AJ, editors. Lymph node biopsy interpretation. 2nd ed. Edinburgh: Churchill Livingstone; 1992. p. 3–28.
Henry PH, Longo DL. Enlargement of the lymph nodes and spleen.
Holland SM, Gallin JI. Disorders of granulocytes and monocytes.
Konkle BA. Bleeding and thrombosis.
O’Malley DP, George TI, Orazi A, editors. Benign and reactive conditions of lymph node and spleen. Washington, DC: ARP Press; 2009.
Rosai J. Chapter 22: Lymph nodes, spleen. In: Rosai J, editor. Rosai and Ackerman’s surgical pathology. 10th ed. St. Louis: Elsevier; 2011.
Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW. WHO classification of tumours. Pathology and genetics. Tumours of haemopoietic and lymphoid tissues. Lyon: IARC Press; 2008.
Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert H, Advani R, Ghielmini M, Salles GA, Zelenetz AD, Jaffe ES. The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood. 2016;127:2375–90.
The Royal College of Pathologists. Tissue pathways for lymph node, spleen and bone marrow trephine biopsy specimens. 3rd ed. 2017. https://www.rcpath.org/profession/publications/cancer-datasets.html Accessed Mar 2017.
The Royal College of Pathologists. Standards for specialist laboratory integration and dataset for the histopathological reporting of lymphomas. 2015. https://www.rcpath.org/profession/publications/cancer-datasets.html. Accessed Oct 2016.
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Venkatraman, L., McManus, D.T. (2017). Lymph Nodes, Spleen, and Bone Marrow. In: Allen, D., Cameron, R. (eds) Histopathology Specimens. Springer, Cham. https://doi.org/10.1007/978-3-319-57360-1_45
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DOI: https://doi.org/10.1007/978-3-319-57360-1_45
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