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Opioids and Antagonists

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Central Pain Syndrome

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Abstract

Opioids (including tramadol and, pending confirmation, cebranopadol) are not indicated in the routine management of CP, alone or in combination (e.g., with aminergics) [1, 2]. The first patient in history to be diagnosed with CP was also opioid unresponsive [3]. Most chronic pain patients on long-term opioids report strong or very strong pain, highlighting their inefficacy [4, 5]. In short-term clinical trials of PNP, the NNT for strong opioids was 4.3 and for tramadol 4.7.

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Authors and Affiliations

  1. HEAVEN/GEMINI International Collaborative Group, Turin, Italy

    Sergio Canavero

  2. AOUCittà della Salute e della Scienza di Torino, Department of Neurosciences, Rita Levi Montalcini, Università di Torino, Turin, Italy

    Vincenzo Bonicalzi

Authors
  1. Sergio Canavero
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  2. Vincenzo Bonicalzi
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Canavero, S., Bonicalzi, V. (2018). Opioids and Antagonists. In: Central Pain Syndrome. Springer, Cham. https://doi.org/10.1007/978-3-319-56765-5_16

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  • DOI: https://doi.org/10.1007/978-3-319-56765-5_16

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-56764-8

  • Online ISBN: 978-3-319-56765-5

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