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Neural and Nerve Sheath Lesions

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Soft Tissue Pathology for Clinicians

Part of the book series: Pathology for Clinicians ((PACLIN))

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Abstract

Peripheral nerves are composed of axons that are supported and insulated by a myelin substance produced by surrounding Schwann cells. These axons are further organized into bundles that are supported and surrounded by connective tissue and covered by perineurium. In neural and nerve sheath neoplasms, one or a combination of these anatomic structures proliferate to form a soft tissue mass.

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References

  1. Fletcher CDM, Bridge JA, Hogendoorn PC, Mertens F, editors. Pathology and genetics of tumours of soft tissue and bone. 4th ed. Lyon: World Health Organization; 2013.

    Google Scholar 

  2. Goldblum J, Weiss S, Folpe AL, editors. Enzinger and Weiss’s soft tissue tumors. 6th ed. Philadelphia: Elsevier; 2013.

    Google Scholar 

  3. MacCollin M, Woodfin W, Kronn D, Short MP. Schwannomatosis: a clinical and pathologic study. Neurology. 1996;46(4):1072–9.

    Article  CAS  PubMed  Google Scholar 

  4. Evans DG. Neurofibromatosis type 2 (NF2): a clinical and molecular review. Orphanet J Rare Dis.

    Google Scholar 

  5. Hornick JL, editor. Practical soft tissue pathology: a diagnostic approach. Philadelphia: Saunders; 2013.

    Google Scholar 

  6. Agaimy A, Vassos N, Croner RS. Gastrointestinal manifestations of neurofibromatosis type 1 (Recklinghausen’s disease): clinicopathological spectrum with pathogenetic considerations. Int J Clin Exp Pathol. 2012;5(9):852–62.

    PubMed  PubMed Central  Google Scholar 

  7. McClatchey AI. Neurofibromatosis. Annu Rev Pathol. 2007;2:191–216.

    Article  CAS  PubMed  Google Scholar 

  8. Woodruff JM. Pathology of tumors of the peripheral nerve sheath in type 1 neurofibromatosis. Am J Med Genet. 1999;89(1):23–30.

    Article  CAS  PubMed  Google Scholar 

  9. Macarenco RS, Ellinger F, Oliveira AM. Perineurioma: a distinctive and underrecognized peripheral nerve sheath neoplasm. Arch Pathol Lab Med. 2007;131(4):625–36.

    PubMed  Google Scholar 

  10. Hornick JL, Fletcher CD. Soft tissue perineurioma: clinicopathologic analysis of 81 cases including those with atypical histologic features. Am J Surg Pathol. 2005;29(7):845–58.

    Article  PubMed  Google Scholar 

  11. Lack EE, Worsham GF, Callihan MD, Crawford BE, Klappenbach S, Rowden G, et al. Granular cell tumor: a clinicopathologic study of 110 patients. J Surg Oncol. 1980;13(4):301–16.

    Article  CAS  PubMed  Google Scholar 

  12. Miettinen M, editor. Modern soft tissue pathology: tumors and non-neoplastic conditions. 1st ed. New York: Cambridge University Press; 2010.

    Google Scholar 

  13. Fine SW, Li M. Expression of calretinin and the alpha-subunit of inhibin in granular cell tumors. Am J Clin Pathol. 2003;119(2):259–64.

    Article  CAS  PubMed  Google Scholar 

  14. Strong EW, McDivitt RW, Brasfield RD. Granular cell myoblastoma. Cancer. 1970;25(2):415–22.

    Article  CAS  PubMed  Google Scholar 

  15. Fanburg-Smith JC, Meis-Kindblom JM, Fante R, Kindblom LG. Malignant granular cell tumor of soft tissue: diagnostic criteria and clinicopathologic correlation. Am J Surg Pathol. 1998;22(7):779–94.

    Article  CAS  PubMed  Google Scholar 

  16. Ducatman BS, Scheithauer BW, Piepgras DG, Reiman HM, Ilstrup DM. Malignant peripheral nerve sheath tumors. A clinicopathologic study of 120 cases. Cancer. 1986;57(10):2006–21.

    Article  CAS  PubMed  Google Scholar 

  17. Zou C, Smith KD, Liu J, Lahat G, Myers S, Wang WL, et al. Clinical, pathological, and molecular variables predictive of malignant peripheral nerve sheath tumor outcome. Ann Surg. 2009;249(6)

    Google Scholar 

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Perry, K. (2017). Neural and Nerve Sheath Lesions. In: Soft Tissue Pathology for Clinicians. Pathology for Clinicians. Springer, Cham. https://doi.org/10.1007/978-3-319-55654-3_9

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  • DOI: https://doi.org/10.1007/978-3-319-55654-3_9

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  • Publisher Name: Springer, Cham

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  • Online ISBN: 978-3-319-55654-3

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