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Periodontal Pathogenesis: Conclusions and Future Directions

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Pathogenesis of Periodontal Diseases

Abstract

This textbook on periodontal pathogenesis aspired to provide an overview of our current understanding of biological processes underlying the disease, and discuss their clinical relevance and applicability. We now realize that periodontal disease affects 10% population in its severe form, and that it is primarily a disease of aging. Despite advances in prevention measures over the past decades, the prevalence of the severe form of disease has not decreased. This highlights periodontitis as an existing health problem, unlikely to be completely resolved with our present therapeutic approaches. Continuous enrichment of our biological knowledge of the disease and continuous efforts in bridging this knowledge to the clinical application will hopefully lead to more holistic approaches for diagnosis, evaluation of patient susceptibility, or selection of efficient treatment options. This conclusive chapter summarizes updates and take-home messages from previous chapters, to consider further.

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References

  1. Marsh PD. Are dental diseases examples of ecological catastrophes? Microbiology. 2003;149(Pt 2):279–94.

    Article  PubMed  Google Scholar 

  2. Hajishengallis G, Lamont RJ. Beyond the red complex and into more complexity: the polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology. Mol Oral Microbiol. 2012;27(6):409–19.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Lamont RJ, Hajishengallis G. Polymicrobial synergy and dysbiosis in inflammatory disease. Trends Mol Med. 2015;21(3):172–83.

    Article  PubMed  Google Scholar 

  4. Sorsa T, Tjaderhane L, Konttinen YT, Lauhio A, Salo T, Lee HM, Golub LM, Brown DL, Mantyla P. Matrix metalloproteinases: contribution to pathogenesis, diagnosis and treatment of periodontal inflammation. Ann Med. 2006;38(5):306–21.

    Article  PubMed  Google Scholar 

  5. Sorsa T, Gursoy UK, Nwhator S, Hernandez M, Tervahartiala T, Leppilahti J, Gursoy M, Kononen E, Emingil G, Pussinen PJ, Mantyla P. Analysis of matrix metalloproteinases, especially MMP-8, in gingival creviclular fluid, mouthrinse and saliva for monitoring periodontal diseases. Periodontol 2000. 2016;70(1):142–63.

    Article  PubMed  Google Scholar 

  6. Garlet GP. Destructive and protective roles of cytokines in periodontitis: a re-appraisal from host defense and tissue destruction viewpoints. J Dent Res. 2010;89(12):1349–63.

    Article  PubMed  Google Scholar 

  7. Belibasakis GN, Bostanci N. The RANKL-OPG system in clinical periodontology. J Clin Periodontol. 2012;39(3):239–48.

    Article  PubMed  Google Scholar 

  8. Bostanci N, Ilgenli T, Emingil G, Afacan B, Han B, Toz H, Atilla G, Hughes FJ, Belibasakis GN. Gingival crevicular fluid levels of RANKL and OPG in periodontal diseases: implications of their relative ratio. J Clin Periodontol. 2007;34(5):370–6.

    Article  PubMed  Google Scholar 

  9. Bostanci N, Saygan B, Emingil G, Atilla G, Belibasakis GN. Effect of periodontal treatment on receptor activator of NF-kappaB ligand and osteoprotegerin levels and relative ratio in gingival crevicular fluid. J Clin Periodontol. 2011;38(5):428–33.

    Article  PubMed  Google Scholar 

  10. Taubman MA, Kawai T, Han X. The new concept of periodontal disease pathogenesis requires new and novel therapeutic strategies. J Clin Periodontol. 2007;34(5):367–9.

    Article  PubMed  Google Scholar 

  11. Nibali L, Di Iorio A, Onabolu O, Lin GH. Periodontal infectogenomics: systematic review of associations between host genetic variants and subgingival microbial detection. J Clin Periodontol. 2016;43(11):889–900.

    Article  PubMed  Google Scholar 

  12. Mitsakakis K, Stumpf F, Strohmeier O, Klein V, Mark D, Von Stetten F, Peham JR, Herz C, Tawakoli PN, Wegehaupt F, Attin T, Bostanci N, Bao K, Belibasakis GN, Hays JP, Elshout G, Huisman RC, Klein S, Stubbs AP, Doms L, Wolf A, Rusu V, Goethel S, Binsl T, Michie A, Jancovicova J, Kolar V, Kostka M, Smutny J, Karpisek M, Estephan C, Cocaud C, Zengerle R. Chair/bedside diagnosis of oral and respiratory tract infections, and identification of antibiotic resistances for personalised monitoring and treatment. Stud Health Technol Inform. 2016;224:61–6.

    PubMed  Google Scholar 

  13. Belibasakis GN, Mylonakis E. Oral infections: clinical and biological perspectives. Virulence. 2015;6(3):173–6.

    Article  PubMed  PubMed Central  Google Scholar 

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Correspondence to Georgios N. Belibasakis .

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Belibasakis, G.N., Bostanci, N. (2018). Periodontal Pathogenesis: Conclusions and Future Directions. In: Bostanci, N., Belibasakis, G. (eds) Pathogenesis of Periodontal Diseases. Springer, Cham. https://doi.org/10.1007/978-3-319-53737-5_9

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  • DOI: https://doi.org/10.1007/978-3-319-53737-5_9

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-53735-1

  • Online ISBN: 978-3-319-53737-5

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