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Etiology

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Clinician's Guide to Mycosis Fungoides
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Abstract

Although many advances have been made for treating mycosis fungoides (MF), the etiology of the disease remains unknown. Many current hypotheses exist on its possible genetic, environmental, and immunologic etiologies. Current hypotheses of MF include genetic and cellular signaling abnormalities such as clonal abnormalities and changes in the expression of adhesion molecules and cytokines. Alterations in the immunological milieu have also been implicated in the pathogenesis of MF.

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References

  1. Sommer V, Clemmensen O, Nielsen O, Wasik M, Lovato P, Brender C, et al. In vivo activation of stat3 in cutaneous t-cell lymphoma. Evidence for an antiapoptotic function of stat3. Leukemia. 2004;18(7):1288–95.

    Article  CAS  PubMed  Google Scholar 

  2. Scarisbrick JJ, Woolford AJ, Russell-Jones R, Whittaker SJ. Loss of heterozygosity on 10q and microsatellite instability in advanced stages of primary cutaneous T-cell lymphoma and possible association with homozygous deletion of PTEN. Blood. 2000;95(9):2937–42.

    CAS  PubMed  Google Scholar 

  3. Navas IC, Ortiz-Romero PL, Villuendas R, Martínez P, García C, Gómez E, et al. P16 ink4a gene alterations are frequent in lesions of mycosis fungoides. Am J Pathol. 2000;156(5):1565–72.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Tracey L, Villuendas R, Dotor AM, Spiteri I, Ortiz P, García JF, et al. Mycosis fungoides shows concurrent deregulation of multiple genes involved in the TNF signaling pathway: an expression profile study. Blood. 2003;102(3):1042–50.

    Article  CAS  PubMed  Google Scholar 

  5. Tan RH, Butterworth C, McLaughlin H, Malka S, Samman P. Mycosis fungoides—a disease of antigen persistence. Br J Dermatol. 1974;91(6):607–16.

    Article  CAS  PubMed  Google Scholar 

  6. Girardi M, Heald PW, Wilson LD. The pathogenesis of mycosis fungoides. N Engl J Med. 2004;350(19):1978–88.

    Article  CAS  PubMed  Google Scholar 

  7. Gemmill R, editor. Cutaneous T-cell lymphoma. Seminars in oncology nursing. Amsterdam: Elsevier; 2006.

    Google Scholar 

  8. Whittemore AS, Holly EA, Lee I-M, Abel EA, Adams RM, Nickoloff BJ, et al. Mycosis fungoides in relation to environmental exposures and immune response: a case-control study. J Natl Cancer Inst. 1989;81(20):1560–7.

    Article  CAS  PubMed  Google Scholar 

  9. Ghosh SK, Abrams J, Terunuma H, Vonderheid EC, DeFreitas E. Human T-cell leukemia virus type I tax/rex DNA and RNA in cutaneous T-cell lymphoma. Blood. 1994;84(8):2663–71.

    CAS  PubMed  Google Scholar 

  10. Wood GS, Salvekar A, Schaffer J, Crooks CF, Henghold W, Fivenson DP, et al. Evidence against a role for human T-cell lymphotrophic virus type I (HTLV-I) in the pathogenesis of American cutaneous T-cell lymphoma. J Invest Dermatol. 1996;107(3):301–7.

    Article  CAS  PubMed  Google Scholar 

  11. Wood GS, Schaffer JM, Boni R, Dummer R, Burg G, Takeshita M, et al. No evidence of HTLV-I proviral integration in lymphoproliferative disorders associated with cutaneous T-cell lymphoma. Am J Pathol. 1997;150(2):667.

    CAS  PubMed  PubMed Central  Google Scholar 

  12. Pancake BA, Zucker-Franklin D, Coutavas EE. The cutaneous T cell lymphoma, mycosis fungoides, is a human T cell lymphotropic virus-associated disease. A study of 50 patients. J Clin Investig. 1995;95(2):547.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Zucker-Franklin D, Pancake BA, editors. The role of human T-cell lymphotropic viruses (HTLV-I and II) in cutaneous T-cell lymphomas. Seminars in dermatology; 1994.

    Google Scholar 

  14. Rowden G, Lewis M. Langerhans cells: involvement in the pathogenesis of mycosis fungoides. Br J Dermatol. 1976;95(6):665–72.

    Article  CAS  PubMed  Google Scholar 

  15. Bani D, Pimpinelli N, Moretti S, Giannotti B. Langerhans cells and mycosis fungoides–a critical overview of their pathogenic role in the disease. Clin Exp Dermatol. 1990;15(1):7–12.

    Article  CAS  PubMed  Google Scholar 

  16. Campbell JJ, Clark RA, Watanabe R, Kupper TS. Sezary syndrome and mycosis fungoides arise from distinct T-cell subsets: a biologic rationale for their distinct clinical behaviors. Blood. 2010;116(5):767–71.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Kim EJ, Hess S, Richardson SK, Newton S, Showe LC, Benoit BM, et al. Immunopathogenesis and therapy of cutaneous T cell lymphoma. J Clin Invest. 2005;115(4):798–812.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Vowels BR, Cassin M, Vonderheid EC, Rook AH. Aberrant cytokine production by Sezary syndrome patients: cytokine secretion pattern resembles murine th2 cells. J Invest Dermatol. 1992;99(1):90–4.

    Article  CAS  PubMed  Google Scholar 

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Khan Mohammad Beigi, P. (2017). Etiology. In: Clinician's Guide to Mycosis Fungoides. Springer, Cham. https://doi.org/10.1007/978-3-319-47907-1_3

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  • DOI: https://doi.org/10.1007/978-3-319-47907-1_3

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-47906-4

  • Online ISBN: 978-3-319-47907-1

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