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GABAB Receptor Functions in the Mesolimbic Dopamine System

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Book cover GABAB Receptor

Part of the book series: The Receptors ((REC,volume 29))

Abstract

GABAB receptors are expressed in neurons of the dopamine system where they bidirectionally modulate activity and release of glutamate, GABA, and dopamine itself. Dopamine has many functions including signaling of salient external stimuli and prediction errors that optimize decision-making, as well as motivation and initiation of movement. GABAB receptors thus exert a second-order modulation, with effects on locomotion, motivation, and reward learning. Moreover, recent findings indicate that neuronal activity may induce a plasticity of GABAB receptor signaling. In this chapter, we review the structural and functional features of GABAB receptor signaling in the dopaminergic system, from subcellular specialization to plasticity and fine-tuning of mesolimbic circuits. Beyond a physiological role GABAB receptors may also affect disease, such as addiction. GABAB receptors may therefore constitute an interesting target for pharmacological interventions to treat this condition.

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Acknowledgments

We thank Tony Lien for comments on the manuscript. A.L.L. and C.L. are supported by grants from the Swiss National Science Foundation.

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Authors and Affiliations

  1. The Gladstone Institutes, San Francisco, CA, 94158, USA

    Arnaud L. Lalive

  2. Department of Basic Neurosciences, Medical Faculty, University of Geneva, Geneva, 1211, Switzerland

    Christian Lüscher

  3. Department of Clinical Neurosciences, Clinic of Neurology, Geneva University Hospital, Geneva, 1211, Switzerland

    Christian Lüscher

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  1. Arnaud L. Lalive
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  2. Christian Lüscher
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Correspondence to Arnaud L. Lalive or Christian Lüscher .

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  1. Neuroscience Institute, National Research Council of Italy Neuroscience Institute, Cagliari, Italy

    Giancarlo Colombo

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Lalive, A.L., Lüscher, C. (2016). GABAB Receptor Functions in the Mesolimbic Dopamine System. In: Colombo, G. (eds) GABAB Receptor. The Receptors, vol 29. Humana Press, Cham. https://doi.org/10.1007/978-3-319-46044-4_8

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