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Cutaneous Adnexal Tumors

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Atlas of Dermatology, Dermatopathology and Venereology

Abstract

The main subtypes of cutaneous adnexal tumors are described in this chapter in accordance with the latest classification of this complex and heterogeneous group of disorders.

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References

  • Agrawal R, Kumar P, Varshney R (2014) Syringocystadenoma papilliferum: an unusual presentation. J Clin Diagn Res 8(5):QD03–QD04

    PubMed  PubMed Central  Google Scholar 

  • Akasaka T, Onodera H, Matsuta M (1997) Cutaneous mixed tumor containing ossification, hair matrix, and sebaceous ductal differentiation. J Dermatol 24(2):125–131

    Article  CAS  PubMed  Google Scholar 

  • Alsaad KO, Obaidat NA, Ghazarian D (2007) Skin adnexal neoplasms – part 1: an approach to tumours of the pilosebaceous unit. J Clin Pathol 60(2):129–144

    Article  CAS  PubMed  Google Scholar 

  • Ambo M, Kumakiri M, Kobayashi H, Ohkawara A (1997) Papillary eccrine adenoma with a pomegranate-like appearance. J Dermatol 24(12):773–776

    Article  CAS  PubMed  Google Scholar 

  • Bates AW, Baithun SI (1998) Atypical mixed tumor of the skin: histologic, immunohistochemical, and ultrastructural features in three cases and a review of the criteria for malignancy. Am J Dermatopathol 20(1):35–40

    Article  CAS  PubMed  Google Scholar 

  • Bidari-Zerehpoosh F, Sabeti S, Arman F, Shakeri H (2017) Eccrine nevus presenting with umbilical discharge: a case report and review of the literature. Case Rep Dermatol Med 2017:9761843

    PubMed  PubMed Central  Google Scholar 

  • Bjarke T, Ternesten-Bratel A, Hedblad M, Rausing A (2003) Carcinoma and eccrine syringofibroadenoma: a report of five cases. J Cutan Pathol 30(6):382–392

    Article  PubMed  Google Scholar 

  • Constantinescu MB, Chan JB, Cassarino DS (2010) Chondroid syringoma with tyrosine crystals: case report and review of the literature. Am J Dermatopathol 32(2):171–174

    Article  PubMed  Google Scholar 

  • Coppola R, Carbotti M, Zanframundo S, Rinati MV, Graziano A, Panasiti V (2015) Use of dermoscopy in the diagnosis of sebaceoma. J Am Acad Dermatol 72(6):e143–e145

    Article  PubMed  Google Scholar 

  • Dai B, Kong YY, Cai X, Shen XX, Kong JC (2014) Spiradenocarcinoma, cylindrocarcinoma and spiradenocylindrocarcinoma: a clinicopathological study of nine cases. Histopathology 65(5):658–666

    Article  PubMed  Google Scholar 

  • Danialan R, Mutyambizi K, Aung P, Prieto VG, Ivan D (2015) Challenges in the diagnosis of cutaneous adnexal tumours. J Clin Pathol 68(12):992–1002

    Article  CAS  PubMed  Google Scholar 

  • DeRosa DC, Lin-Hurtubise K (2012) Pilomatricoma: an unusual dermatologic neoplasm. Hawaii J Med Public Health 71(10):282–286

    PubMed  PubMed Central  Google Scholar 

  • Dowerah S, Dutta A, Saikia P (2015) Tubular apocrine adenoma. J Health Res Rev 2:78–79

    Article  Google Scholar 

  • Dua J, Grabczynska S (2014) Eccrine nevus affecting the forearm of an 11-year-old girl successfully controlled with topical glycopyrrolate. Pediatr Dermatol 31(5):611–612

    Article  PubMed  Google Scholar 

  • El khannoussi B, Hechlaf H, Lalya I, Oukabli M, Al Bouzidi A, Ortonne N (2012) Syringomatous carcinoma: case report of a rare tumor entity. Pan Afr Med J 12:76

    Google Scholar 

  • Ferrari A, Buccini P, Silipo V, De Simone P, Mariani G, Marenda S, Hagman JH, Amantea A, Panetta C, Catricalà C (2009) Eccrine poroma: a clinical-dermoscopic study of seven cases. Acta Derm Venereol 89(2):160–164

    PubMed  Google Scholar 

  • Flux K (2017) Sebaceous neoplasms. Surg Pathol Clin 10(2):367–382

    Article  PubMed  Google Scholar 

  • Folpe AL, Reisenauer AK, Mentzel T, Rütten A, Solomon AR (2003) Proliferating trichilemmal tumors: clinicopathologic evaluation is a guide to biologic behavior. J Cutan Pathol 30(8):492–498

    Article  PubMed  Google Scholar 

  • Frings VG, Trautmann A, Goebeler M, Wobser M (2017) Dermpath & clinic: multiple reactive eccrine syringofibroadenomas. Eur J Dermatol 27(1):102–104

    PubMed  Google Scholar 

  • Furlan KC, Kakizaki P, Chartuni JCN, Sittart JA, Valente NYS (2017) Hidroacanthoma simplex: dermoscopy and cryosurgery treatment. An Bras Dermatol 92(2):253–255

    Article  PubMed  PubMed Central  Google Scholar 

  • Gokalp H, Gurer MA, Alan S (2013) Trichofolliculoma: a rare variant of hair follicle hamartoma. Dermatol Online J 19(8):19264

    PubMed  Google Scholar 

  • Haddad N, Jd OF, Reis MJ, Michalany AO, Nasser Kda R, Corbett AM (2014) Tumor of follicular infundibulum with unique features. An Bras Dermatol 89(6):964–966

    Article  PubMed  PubMed Central  Google Scholar 

  • Hernández-Núñez A, Nájera Botello L, Romero Maté A, Martínez-Sánchez C, Utrera Busquets M, Calderón Komáromy A, Borbujo Martínez J (2014) Retrospective study of pilomatricoma: 261 tumors in 239 patients. Actas Dermosifiliogr 105(7):699–705

    Article  PubMed  Google Scholar 

  • Herrmann JL, Allan A, Trapp KM, Morgan MB (2014) Pilomatrix carcinoma: 13 new cases and review of the literature with emphasis on predictors of metastasis. J Am Acad Dermatol 71(1):38–43.e2

    Article  PubMed  Google Scholar 

  • Hoang MP, Dresser KA, Kapur P, High WA, Mahalingam M (2008) Microcystic adnexal carcinoma: an immunohistochemical reappraisal. Mod Pathol 21(2):178–185

    Article  CAS  PubMed  Google Scholar 

  • Hollowell KL, Agle SC, Zervos EE, Fitzgerald TL (2012) Cutaneous apocrine adenocarcinoma: defining epidemiology, outcomes, and optimal therapy for a rare neoplasm. J Surg Oncol 105(4):415–419

    Article  PubMed  Google Scholar 

  • Huang Y (2013) Dermal duct tumor with prominent ductal and sebaceous differentiation. Indian J Pathol Microbiol 56(3):297–299

    Article  PubMed  Google Scholar 

  • Idriss MH, Khalil A, Long W, Elston DM (2013) Epidermal panfolliculoma: an adnexal proliferation with advanced follicular differentiation confined to the epidermis. J Cutan Pathol 40(4):409–412

    Article  PubMed  Google Scholar 

  • Jakobiec FA, Rai R, Lefebvre DR (2014) Papillary hidradenoma of the eyelid margin: clinical and immunohistochemical observations further supporting an apocrine rather than an eccrine origin. Surv Ophthalmol 59(5):540–547

    Article  PubMed  Google Scholar 

  • Kamalpour L, Brindise RT, Nodzenski M, Bach DQ, Veledar E, Alam M (2014) Primary cutaneous mucinous carcinoma: a systematic review and meta-analysis of outcomes after surgery. JAMA Dermatol 150(4):380–384

    Article  PubMed  Google Scholar 

  • Kamiya H, Oyama Z, Kitajima Y (2001) “Apocrine” poroma: review of the literature and case report. J Cutan Pathol 28(2):101–104

    Article  CAS  PubMed  Google Scholar 

  • Kang MJ, Yu DS, Kim JW (2008) A case of eccrine nevus. Ann Dermatol 20(1):29–31

    Article  PubMed  PubMed Central  Google Scholar 

  • Kazakov DV, Mukensnabl P, Michal M (2006) Tubular adenoma of the skin with follicular and sebaceous differentiation: a report of two cases. Am J Dermatopathol 28(2):142–146

    Article  PubMed  Google Scholar 

  • Kazakov DV, Belousova IE, Bisceglia M, Calonje E, Emberger M, Grayson W, Hantschke M, Kempf W, Kutzner H, Michal M, Spagnolo DV, Virolainen S, Zelger B (2007) Apocrine mixed tumor of the skin (“mixed tumor of the folliculosebaceous-apocrine complex”). Spectrum of differentiations and metaplastic changes in the epithelial, myoepithelial, and stromal components based on a histopathologic study of 244 cases. J Am Acad Dermatol 57(3):467–483

    Article  PubMed  Google Scholar 

  • Kazakov DV, Magro G, Kutzner H, Spagnolo DV, Yang Y, Zaspa O, Mukensnabl P, Michal M (2008) Spiradenoma and spiradenocylindroma with an adenomatous or atypical adenomatous component: a clinicopathological study of 6 cases. Am J Dermatopathol 30(5):436–441

    Article  PubMed  Google Scholar 

  • Khoja AA, Yan B, Lee SJ, Cheong EC, Tan KB (2011) Proliferating tricholemmal tumour: clinicopathological aspects of a case. Singap Med J 52(12):e255–e257

    CAS  Google Scholar 

  • Krishnamurthy J, Divya K (2010) The cytology of giant solitary trichoepithelioma. J Cytol 27(3):99–101

    Article  PubMed  PubMed Central  Google Scholar 

  • Kushner JA, Thomas RS, Young RJ (2014) An unusual location of a pilar sheath acanthoma. Int J Trichol 6(4):185–186

    Article  Google Scholar 

  • Laffay L, Depaepe L, d’Hombres A, Balme B, Thomas L, De Bari B (2012) Histological features and treatment approach of trichoblastic carcinomas: from a case report to a review of the literature. Tumori 98(2):46e–49e

    Article  PubMed  Google Scholar 

  • Lal K, Morrell TJ, Cunningham M, OʼDonnell P, Levin NA, Cornejo KM (2018) A case of a malignant cutaneous mixed tumor (Chondroid syringoma) of the scapula treated with staged margin-controlled excision. Am J Dermatopathol 40(9):679–681

    Article  PubMed  Google Scholar 

  • Lee JS, Kwon JH, Jung GS, Lee JW, Yang JD, Chung HY, Cho BC, Choi KY (2018) A giant trichoblastic carcinoma. Arch Craniofac Surg 19(4):275–278

    Article  PubMed  PubMed Central  Google Scholar 

  • Lestouquet FR, Sánchez Moya AI, Guerra SH, Cardona Alzate CJ (2013) Primary cutaneous adenoid cystic carcinoma: an unusual case. Dermatol Online J 19(1):5

    PubMed  Google Scholar 

  • Maher EE, Vidal CI (2015) Trichilemmoma. Cutis 96(2):81, 104–106

    PubMed  Google Scholar 

  • Marques-da-Costa J, Campos-do-Carmo G, Ormiga P, Ishida C, Cuzzi T, Ramos-e-Silva M (2015) Sebaceous adenoma: clinics, dermatoscopy, and histopathology. Int J Dermatol 54(6):e200–e202

    Article  PubMed  Google Scholar 

  • Misago N, Inoue T, Toda S (2016) Intraepidermal benign sebaceous neoplasm: apocrine poroma (hidroacanthoma simplex type) with extensive sebaceous differentiation with sebaceoma-like features. J Cutan Pathol 43(2):171–176

    Article  PubMed  Google Scholar 

  • Nagai Y, Kazama S, Yamada D, Miyagawa T, Murono K, Yasuda K, Nishikawa T, Tanaka T, Kiyomatsu T, Hata K, Kawai K, Masui Y, Nozawa H, Yamaguchi H, Ishihara S, Kadono T, Watanabe T (2016) Perianal and vulvar extramammary Paget disease: a report of six cases and mapping biopsy of the anal canal. Ann Dermatol 28(5):624–628

    Article  PubMed  PubMed Central  Google Scholar 

  • Nascimento BA, Carneiro CM, Carvalho AH, Bittencourt Mde J, Drago MG, Freitas LK (2015) Syringocystadenoma papilliferum in an unusual location. An Bras Dermatol 90(6):900–902

    Article  PubMed  PubMed Central  Google Scholar 

  • North JP, McCalmont TH, Ruben BS (2016) Cutaneous adnexal tumors. Resource document. UpToDate. https://www.uptodate.com/contents/cutaneous-adnexal-tumors

  • Papadakis M, de Bree E, Floros N, Giannikaki E, Xekalou A, Manios A (2017) Pilomatrix carcinoma: more malignant biological behavior than was considered in the past. Mol Clin Oncol 6(3):415–418

    Article  PubMed  PubMed Central  Google Scholar 

  • Penev J, Bakardzhiev I, Chokoeva AA, Wollina U, Tchernev G (2016) Disseminated trichoblastomas – successfull treatment with CO(2) laser. J Eur Acad Dermatol Venereol 30(12):e219–e220

    Article  CAS  PubMed  Google Scholar 

  • Pitarch G, Botella-Estrada R (2015) Dermoscopic findings in trichoblastoma. Actas Dermosifiliogr 106(9):e45–e48

    Article  CAS  PubMed  Google Scholar 

  • Riera-Leal L, Guevara-Gutiérrez E, Barrientos-García JG, Madrigal-Kasem R, Briseño-Rodríguez G, Tlacuilo-Parra A (2015) Eccrine porocarcinoma: epidemiologic and histopathologic characteristics. Int J Dermatol 54(5):580–586

    Article  PubMed  Google Scholar 

  • Roismann M, Freitas RR, Ribeiro LC, Montenegro MF, Biasi LJ, Jung JE (2011) Trichilemmal carcinoma: case report. An Bras Dermatol 86(5):991–994

    Article  PubMed  Google Scholar 

  • Romero-Pérez D, García-Bustinduy M, Cribier B (2017) Clinicopathologic study of 90 cases of trichofolliculoma. J Eur Acad Dermatol Venereol 31(3):e141–e142

    Article  PubMed  Google Scholar 

  • Sawaya JL, Khachemoune A (2014) Poroma: a review of eccrine, apocrine, and malignant forms. Int J Dermatol 53(9):1053–1061

    Article  PubMed  Google Scholar 

  • Segars K, Gopman JM, Elston JB, Harrington MA (2015) Nevus sebaceus of Jadassohn. Eplasty 15:ic38

    PubMed  PubMed Central  Google Scholar 

  • Shan SJ, Guo Y (2014) Panfolliculoma and histopathologic variants: a study of 19 cases. Am J Dermatopathol 36(12):965–971

    Article  PubMed  Google Scholar 

  • Shimanovich I, Krahl D, Rose C (2010) Trichoadenoma of Nikolowski is a distinct neoplasm within the spectrum of follicular tumors. J Am Acad Dermatol 62(2):277–283

    Article  PubMed  Google Scholar 

  • Soni A, Bansal N, Kaushal V, Chauhan AK (2015) Current management approach to hidradenocarcinoma: a comprehensive review of the literature. Ecancermedicalscience 9:517

    Article  PubMed  PubMed Central  Google Scholar 

  • Staiger RD, Helmchen B, Papet C, Mattiello D, Zingg U (2017) Spiradenocarcinoma: a comprehensive data review. Am J Dermatopathol 39(10):715–725

    Article  PubMed  Google Scholar 

  • Suchak R, Wang WL, Prieto VG, Ivan D, Lazar AJ, Brenn T, Calonje E (2012) Cutaneous digital papillary adenocarcinoma: a clinicopathologic study of 31 cases of a rare neoplasm with new observations. Am J Surg Pathol 36(12):1883–1891

    Article  PubMed  Google Scholar 

  • Suchonwanit P, Ruangchainikom P, Apibal Y (2015) Eruptive tumors of the follicular infundibulum: an unexpected diagnosis of hypopigmented macules. Dermatol Ther (Heidelb) 5(3):207–211

    Article  Google Scholar 

  • Temnithikul B, Jerasutus S, Sudtikoonaseth P, Voravutinon N, Kootiratrakarn T, Kattipathananpong P (2016) Eccrine syringofibroadenoma (ESFA): a report of two cases. Dermatol Pract Concept 6(1):5–8

    Article  PubMed  PubMed Central  Google Scholar 

  • Tey HL (2009) Characterizing the nature of eccrine syringofibroadenoma: illustration with a case showing spontaneous involution. Clin Exp Dermatol 34(5):e66–e68

    Article  CAS  PubMed  Google Scholar 

  • Tsai JH, Huang WC, Jhuang JY, Jeng YM, Cheng ML, Chiu HY, Kuo KT, Liau JY (2014) Frequent activating HRAS mutations in trichilemmoma. Br J Dermatol 171(5):1073–1077

    Article  CAS  PubMed  Google Scholar 

  • Urso C, Bondi R, Paglierani M, Salvadori A, Anichini C, Giannini A (2001) Carcinomas of sweat glands: report of 60 cases. Arch Pathol Lab Med 125(4):498–505

    CAS  PubMed  Google Scholar 

  • Vang R, Cohen PR (1999) Ectopic hidradenoma papilliferum: a case report and review of the literature. J Am Acad Dermatol 41(1):115–118

    Article  CAS  PubMed  Google Scholar 

  • Wagner G, Sachse MM (2011) Extramammary Paget disease – clinical appearance, pathogenesis, management. J Dtsch Dermatol Ges 9(6):448–454

    PubMed  Google Scholar 

  • Zhuang SM, Zhang GH, Chen WK, Chen SW, Wang LP, Li H, Song M (2013) Survival study and clinicopathological evaluation of trichilemmal carcinoma. Mol Clin Oncol 1(3):499–502

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Correspondence to Annalisa Patrizi or Ambra Di Altobrando .

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Patrizi, A., Dika, E., Fanti, P.A., Misciali, C., Di Altobrando, A. (2020). Cutaneous Adnexal Tumors. In: Smoller, B., Bagherani, N. (eds) Atlas of Dermatology, Dermatopathology and Venereology . Springer, Cham. https://doi.org/10.1007/978-3-319-45134-3_80-1

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  • DOI: https://doi.org/10.1007/978-3-319-45134-3_80-1

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