Abstract
The abnormal findings in the pudgy mouse are remarkably similar to those in the severe case of human congenital scoliosis such as seen in the spondylocostal dysplasias. The pudgy mouse is an excellent model to study: (i) how gene mutations translate into three-dimensional structural abnormalities and (ii) which other factors contribute to the final deformities.
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Acknowledgments
We thank Lauren Barone, George Malatantis, Christopher Cahill, and Evelyn Flynn for excellent technical help and “Advanced Medical Graphics” of Boston, MA, for excellent assistance in the presentation of the figures.
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© 2016 Springer International Publishing Switzerland
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Shapiro, F. (2016). Conclusions. In: Disordered Vertebral and Rib Morphology in Pudgy Mice. Advances in Anatomy, Embryology and Cell Biology, vol 221. Springer, Cham. https://doi.org/10.1007/978-3-319-43151-2_5
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DOI: https://doi.org/10.1007/978-3-319-43151-2_5
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