Abstract
The analysis of natriuretic peptides in blood is important and widely used for clinical practice for the diagnosis and management of patients with heart failure. As with the analysis of any biomarker, the analytical attributes of the assay for B-type natriuretic peptide and NT-proBNP can influence the interpretation of results. Point-of-care testing is an attractive alternative to sending samples to a central laboratory. The advantage of getting results sooner must be weighed into the additional costs and sacrifice in analytical performance.
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References
Hall C. Essential biochemistry and physiology of (NT-pro)BNP. Eur J Heart Fail. 2004;6:257–60.
Kim HA, Januzzi JL. Natriuretic peptide testing in heart failure. Circulation. 2011;123:2015–9.
Dries DL, Ky B, Wu AH, Rame JE, Putt ME, Cappola TP. Simultaneous assessment of unprocessed ProBNP1-108 in addition to processed BNP32 improves identification of high-risk ambulatory patients with heart failure. Circ Heart Fail. 2010;3:220–7.
Giuliani I, Rieunier F, Larue C, Delagneau JF, Granier C, Pau B, Ferriere M, et al. Assay for measurement of intact B-type natriutretic peptide prohormone in blood. Clin Chem. 2006;52:1054–61.
Clerico A, Giannoni A, Vittorini S, Emdin M. The paradox of low BNP levels in obesity. Heart Fail Rev. 2012;17:81–96.
McCullough PA, Sandberg KR. B-type natriuretic peptide and renal disease. Heart Fail Rev. 2003;8:355–8.
Kupchak P, Wu AHB, Ghani F, Newby LK, Ohman EH, Christenson RH. The influence of imprecision on receiver-operating characteristic curve analysis for cardiac markers. Clin Chem. 2006;52:752–3.
Luckenbill KN, Christenson RH, Jaffe AS, Mair J, Ordonez-Llanos J, Pagani F, Tate JR, Wu AHB, Ler R, Apple FS. Cross-reactivity of BNP, NT-proBNP and proBNP in commercial BNP and NT-proBNP assays: preliminary observations. Clin Chem. 2008;54:619–21.
Fraser CG. Biological variation: from principles to practice. Washington DC: AACC Press; 2002.
Fokkema MR, Herrmann Z, Muskiet FAJ, Moecks J. Reference change values for brain natriuretic peptide revisted. Clin Chem. 2006;52:1602–3.
Wu AHB. Serial testing of B-type natriuretic peptide and NTpro-BNP for monitoring therapy of heart failure: the role of biological variation in interpretation of results. Am Heart J. 2006;152:828–34.
Wu AHB, Wians Jr F, Jaffe AS. Biological variation of galectin-3 and soluble ST2 for chronic heart failure: implication on interpretation of test results. Am Heart J. 2013;165:995–9.
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Wu, A.H.B. (2016). Natriuretic Peptides: Basic Analytic Considerations. In: Maisel, A., Jaffe, A. (eds) Cardiac Biomarkers. Springer, Cham. https://doi.org/10.1007/978-3-319-42982-3_14
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DOI: https://doi.org/10.1007/978-3-319-42982-3_14
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