Abstract
This paper focus on bio-robots driven by cardiomyocyte-powered actuators. Towards biomaterial-based robotic actuators that exhibit co-operative motion, this study intends to deal with mutual entrainment between two cardiac-oscillators with mechanical interaction. The cardiac-oscillator is an oriented collagen sheet seeded cultured rat cardiomyocytes. Mechanically coupled cardiac-oscillator sysytem was developed consisting of two cardiac-oscillators connected mechanically via a PDMS film. Mechanically coupled cardiac-oscillator system and a single cardiac-oscillator was applied electric stimulation for investigating the function of mechanical structure. As a result of experiment, we observed mutual entrainment occurred in only mechanically coupled structure.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Webster, V.A., Hawley, E.L., Akkus, O., Chiel, H.J., Quinn, R.D.: Fabrication of electrocompacted aligned collagen morphs for cardiomyocyte powered living machines. In: Wilson, S.P., Verschure, P.F.M.J., Mura, A., Prescott, T.J. (eds.) Living Machines 2015. LNCS, vol. 9222, pp. 429–440. Springer, Heidelberg (2015)
Nawroth, J.C., Lee, H., Feinberg, A.W., Ripplinger, C.M., McCain, M.L., Grosberg, A., Dabiri, J.O., Perker, K.K.: A tissue-engineered jellyfish with biomimetic propulsion. Nat. Biotechnol. 30, 792–797 (2012)
Akiyama, Y., Odaira, K., Sakiyama, K., Hoshino, T., Iwabuchi, K., Morishima, K.: Rapidly-moving insect muscle-powered microrobot and its chemical acceleration. Biomed. Microdevices 14(6), 979–986 (2012)
Bers, D.M.: Cardiac excitation-contraction coupling. Nature 415(6868), 198–205 (2002)
Iribe, G., Jin, H., Naruse, K.: Role of sarcolemmal BKCa channels in stretch-induced extrasystoles in isolated chick hearts. Circ. J. 75(11), 2552–2558 (2011)
Isobe, Y., Kosaka, T., Kuwahara, G., Mikami, H., Saku, T., Kodama, S.: Oriented collagen scaffolds for tissue engineering. Materials 5(3), 501–511 (2012)
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer International Publishing Switzerland
About this paper
Cite this paper
Maekawa, K., Inoue, N., Shimizu, M., Isobe, Y., Saku, T., Hosoda, K. (2016). Mutual Entrainment of Cardiac-Oscillators Through Mechanical Interaction. In: Lepora, N., Mura, A., Mangan, M., Verschure, P., Desmulliez, M., Prescott, T. (eds) Biomimetic and Biohybrid Systems. Living Machines 2016. Lecture Notes in Computer Science(), vol 9793. Springer, Cham. https://doi.org/10.1007/978-3-319-42417-0_48
Download citation
DOI: https://doi.org/10.1007/978-3-319-42417-0_48
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-42416-3
Online ISBN: 978-3-319-42417-0
eBook Packages: Computer ScienceComputer Science (R0)