Skip to main content

Nonimmunologic Contact Urticaria

  • Living reference work entry
  • First Online:
Kanerva’s Occupational Dermatology

Abstract

Rapid onset of sign and symptoms

Minimal exposure may produce burn, sting, and itch only

At high exposure, almost all respond

Morphology – redness and urtication

Often confused with other forms of irritation

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

References

  • Amin S, Lahti A, Maibach HI (eds) (1997) Contact Urticaria syndrome. CRC Press, Boca Raton

    Google Scholar 

  • Basketter DA, Lahti A (2011) Immediate contact reactions. In: Johansen JD, Frosch PF, Lepoittevin JP (eds) Contact Dermatitis, 5th edn. Springer, Berlin, pp 137–154

    Chapter  Google Scholar 

  • Basketter DA, Wilhelm KP (1996) Studies on non-immune immediate contact reactions in an unselected population. Contact Dermatitis 35:237–240

    Article  CAS  PubMed  Google Scholar 

  • Bernstein JE, Swift RM, Soltani K, Lorincz AL (1981) Inhibition of axon reflex vasodilatation by topically applied capsaicin. J Invest Dermatol 76(5)

    Google Scholar 

  • Cheng K, Wu J, Wu KK, Sturino C, Metters K, Gottesdiener K et al (2006) Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans. Proc Natl Acad Sci USA 103(17):6682–6687

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cocchiara J, Letizia CS, Lalko J, Lapczynski A, Api AM (2005) Fragrance material review on cinnamaldehyde. Food Chem Toxicol 43:867–923

    Article  CAS  PubMed  Google Scholar 

  • Coyerly J, Peters L, Whittle E, Basketter D (1998) Susceptibility to skin stinging, non-immunologic contact urticaria and acute skin irritation; is there a relationship? Contact Dermatitis 38(2):90–95

    Article  Google Scholar 

  • Giménez-Arnau A, Maurer M, De La Cuadra J, Maibach H (2010) Immediate contact skin reactions, an update of contact Urticaria, contact Urticaria syndrome and protein contact dermatitis – “a never ending story”. Eur J Dermatol 20(5):552–562

    PubMed  Google Scholar 

  • Giménez-Arnau AM, Maibach HI (eds) (2015) Contact urticaria syndrome. CRC Press, Boca Raton

    Google Scholar 

  • Gollhausen R, Kligman AM (1985) Human assay for identifying substances which induce non-allergic contact urticaria: the NICU-test. Contact Dermatitis 3(2):98–106

    Article  Google Scholar 

  • Hannuksela M (1995) Skin tests for immediate hypersensitivity. In: Rycroft RJG, Menné T, Frosch PJ (eds) Textbook of contact dermatitis. Springer, Berlin/Heidelberg/New York, pp 287–292

    Chapter  Google Scholar 

  • Hannuksela M (1980) Atopic contact dermatitis. Contact Dermatitis 6(1):30–32

    Article  CAS  PubMed  Google Scholar 

  • Hannuksela M (1986) Contact urticaria from foods. In: Roe DA (ed) Nutrition and the skin, vol 10. Liss, New York, pp 153–162

    Google Scholar 

  • Hannuksela A, Lahti A, Hannuksela M (1989) Nonimmunologic immediate contact reactions to three isomers of pyridine carboxaldehyde. Current topics in contact dermatitis. Springer, p. 448–452

    Google Scholar 

  • Hannuksela A, Niinimäki A, Hannuksela M (1993) Size of the test area does not affect the result of the repeated open application test. Contact Dermatitis 28(5):299–300

    Article  CAS  PubMed  Google Scholar 

  • Hjorth N, Roed-Petersen J (1976) Occupational protein contact dermatitis in food handlers. Contact Dermatitis 2(1):28–42

    Article  CAS  PubMed  Google Scholar 

  • Johansson J, Lahti A (1988) Topical non-steroidal anti-inflammatory drugs inhibit non-immunologic immediate contact reactions. Contact Dermatitis 19(3):161–165

    Article  CAS  PubMed  Google Scholar 

  • Kujala T, Lathi A (1989) Duration of inhibition of non-immunologic immediate contact reactions by acetylsalicylic acid. Contact Dermatitis 21(1):60–61

    Article  CAS  PubMed  Google Scholar 

  • Lahti A (1980) Non-immunologic contact urticaria. Acta Dermatol Venereol 60:1–49

    Google Scholar 

  • Lahti A (1987) Terfenadine does not inhibit non-immunologic contact urticaria. Contact Dermatitis 16(4):220–223

    Article  CAS  PubMed  Google Scholar 

  • Lahti A (1995) Immediate contact reactions. In: Rycroft RJG, Menné T, Frosch PJ (eds) Textbook of contact dermatitis. Springer, Berlin/Heidelberg/New York, pp 62–74

    Chapter  Google Scholar 

  • Lahti A, Maibach HI (1984) An animal model for nonimmunologic contact urticaria. Toxicol Appl Pharmacol 76(2):219–224. https://doi.org/10.1016/0041-008X(84)90002-4

  • Lahti A, Maibach HI (1985) Species specificity of nonimmunologic contact urticaria: guinea pig, rat, and mouse. J Am Acad Dermatol 13(1):66–69. https://doi.org/10.1016/S0190-9622(85)70144-2

  • Lahti A, Oikarinen A, Viinikka L, Ylikorkala O, Hannuksela M (1983) Prostaglandins in contact urticaria induced by benzoic acid. Acta Derm Venereol 63(5):42542–42547

    Google Scholar 

  • Lahti A, Väänänen A, Kokkonen EL, Hannuksela M (1987) Acetylsalicylic acid inhibits non-immunologic contact urticaria. Contact Dermatitis 16(3):133–135

    Article  CAS  PubMed  Google Scholar 

  • Lahti A, Larmi E, Hannuksela M (1988) Ultraviolet light inhibits nonimmunologic immediate contact reactions to benzoic acid. Arch Dermatol Res 280(7):420–423

    Article  PubMed  Google Scholar 

  • Lahti A, Poutianen AM, Hannuksela M (1993) Alcohol vehicles in tests for non-immunological immediate contact reactions. Contact Dermatitis 29(1):22–25

    Article  CAS  PubMed  Google Scholar 

  • Larmi E (1989) Systemic effect of ultraviolet irradiation on non-immunologic immediate contact reactions to benzoic acid and methyl nicotinate. Acta Derm Venereol 69(4):296–301

    PubMed  CAS  Google Scholar 

  • Larmi E, Lahti A, Hannuksela M (1989a) Effects of capsaicin and topical anesthesia on nonimmunologic immediate contact reactions to benzoic acid and methyl nicotinate. Current topics in contact dermatitis. Springer, pp 441–447

    Google Scholar 

  • Larmi E, Lahti A, Hannuksela M (1989b) Immediate contact reactions to benzoic acid and the sodium salt of pyrrolidone carboxylic acid comparison of various skin sites. Contact Dermatitis 20(1):38–40

    Article  CAS  PubMed  Google Scholar 

  • Letizia CS, Cocchiara J, Lapczynski A, Lalko J, Api AM (2005) Fragrance material review on cinnamic acid. Food Chem Toxicol 43:925–943

    Article  CAS  PubMed  Google Scholar 

  • Maibach HI, Johnson HL (1975) Contact Urticaria syndrome: contact Urticaria to Diethyltoluamide (immediate-type hypersensitivity). Arch Dermatol 111(6):726–730

    Article  CAS  PubMed  Google Scholar 

  • Richters RJ, Uzunbajakava NE, van Erp PE, van de Kerkhof PC (2017) What is sensitive skin? sensitive skin syndrome, 2nd edn. CRC Press, pp 12–21

    Google Scholar 

  • Sjögren F, Anderson C (2000) The spectrum of inflammatory cell response to dimethyl sulfoxide. Contact Dermatitis 42:216–221

    Article  PubMed  Google Scholar 

  • Sood A, Arora R (2009) Mechanisms of flushing due to niacin and abolition of these effects. J Clin Hypertens 11:685–689

    Article  CAS  Google Scholar 

  • Ylipieti S, Lahti A (1989) Effect of the vehicle on non-immunologic immediate contact reactions. Contact Dermatitis 21(2):105–106

    Article  CAS  PubMed  Google Scholar 

  • Zhai H, Zheng Y, Fautz R, Fuchs A, Maibach H (2012) Reactions of nonimmunologic contact urticaria on scalp, face, and back. Skin Res Technol 18(4):436–441

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to John Havens Cary .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG, part of Springer Nature

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Cary, J.H., Maibach, H.I., Yamaguchi, I., Lahti, A. (2018). Nonimmunologic Contact Urticaria. In: John, S., Johansen, J., Rustemeyer, T., Elsner, P., Maibach, H. (eds) Kanerva’s Occupational Dermatology. Springer, Cham. https://doi.org/10.1007/978-3-319-40221-5_209-2

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-40221-5_209-2

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-40221-5

  • Online ISBN: 978-3-319-40221-5

  • eBook Packages: Springer Reference MedicineReference Module Medicine

Publish with us

Policies and ethics