Abstract
Water is essential for health and survival. Water needed for health exceeds the amount the body produces through metabolic activity. Although water intake is predominantly as free water or in liquid drinks, about a quarter comes from solid foods such as meats and vegetables. Water exists as total body water (TBW) that constantly replenishes and occurs in intracellular and extracellular compartments. Recommended daily water intake is 3.0 L in men and 2.5 L in women and decreases with normal aging; inadequate intake in healthy elderly results in increased morbidity and mortality. Amyotrophic lateral sclerosis (ALS), a neurodegenerative disease of middle age, causes diffuse weakness with dysfunction in the limbs and bulbar muscles accompanied by erosion of quality of life and early death from respiratory failure. Although often discussed in ALS circles, the assessment and management of dehydration are frequently overlooked. Dehydration assessed by the gold standard-labeled water method to examine daily water turnover, a surrogate for water intake, occurs in 20% of ALS patients at first evaluation; its degree increases as the disease progresses. TBW and water turnover are 1,200 ml (3.4%) and 260 ml/day (8.6%) lower, respectively, in ALS patients compared to age- and gender-matched healthy controls. Risk factors for poor hydration are female gender, bulbar-onset disease, malnutrition estimated by body mass index, and low lung function measured by incentive spirometry. As in the healthy elderly population, decreased water intake adversely affects survival in ALS patients. Equations used to estimate daily water requirement, recommended by the US Centers for Medicare and Medicaid Services in healthy elderly, are inaccurate for use in ALS patients. Validated equations are now available to accurately estimate hydration using endpoints routinely assessed in ALS clinics. As with nutrition, hydration should be regularly examined at ALS clinic visits using these equations to assess water requirements and improve clinical care.
Abbreviations
- ALS:
-
Amyotrophic lateral sclerosis
- ALSFRS-6:
-
Summed scores for speech, handwriting, dressing & hygiene, turning in bed and adjusting bedclothes, walking and dyspnea components of ALSFRS-R (normal = 24)
- ALSFRS-R:
-
Amyotrophic lateral sclerosis functional rating scale-revised
- BMI:
-
Body mass index
- DLW:
-
Doubly labeled water
- FVC:
-
Forced vital capacity
- H-B:
-
Harris-Benedict
- OR:
-
Odds ratio
- TBW:
-
Total body water
- TDEE:
-
Total daily energy expenditure
References
Begum MN, Johnson CS (2010) A review of the literature on dehydration in the institutionalized elderly. Eur J Clin Nutr Metab 5(1):e47–e53
Borra SI, Beredo R, Kleinfeld M (1995) Hypernatremia in the aging: causes, manifestations, and outcome. J Natl Med Assoc 87(3):220–224
Bouteloup C, Desport JC, Clavelou P et al (2009) Hypermetabolism in ALS patients: an early and persistent phenomenon. J Neurol 256(8):1236–1242
Cedarbaum JM, Stambler N, Malta E et al (1999) The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function. J Neurol Sci 169(1):13–21
Chidester JC, Spangler AA (1997) Fluid intake in the institutionalized elderly. J Am Diet Assoc 97(1):23–28
Chio A, Logroscino G, Hardiman O, EURALS Consortium et al (2009) Prognostic factors in ALS: a critical review. Amyotroph Lateral Scler J 10(5–6):310–323
Delwaide PA, Delwaide PJ, Penders CA (1972) Isotope studies of body composition in neuromuscular diseases. J Neurol Sci 15(3):339–349
Desport JC, Preux PM, Truong TC et al (1999) Nutritional status is a prognostic factor for survival in ALS patients. Neurology 53(5):1054–1059
Desport JC, Preux PM, Magy L et al (2001) Factors correlated with hypermetabolism in patients with amyotrophic lateral sclerosis. Am J Clin Nutr 74(3):328–334
Efron B, Hastie T, Johnstone I, Tibshirani R (2004) Least angle regression. Ann Stat 32(2):407–499
Fjeld CR, Brown KH, Schoeller DA (1988) Validation of the deuterium oxide method for measuring average daily milk intake in infants. Am J Clin Nutr 48(3):671–679
Gibson S, Shirreffs SM (2013) Beverage consumption habits “24/7” among British adults: association with total water intake and energy intake. Nutr J 12(9):1–13
Grandjean AC, Grandjean NR (2007) Dehydration and cognitive performance. J Am Coll Nutr 26(suppl 5):549S–554S
Harris JA, Benedict FG (1918) A biometric study of human basal metabolism. Proc Natl Acad Sci USA 4(12):370–373
Helderman JH, Vestal RE, Rowe JW et al (1978) The response of arginine vasopressin to intravenous ethanol and hypertonic saline in man: the impact of aging. J Gerontol 33(1):39–47
Kasarskis EJ, Mendiondo M, Wells R, ALS Nutrition/NIPPV Study Group et al (2011) The ALS nutrition/NIPPV study: design, feasibility, and initial results. Amyotroph Lateral Scler 12:17–25
Kasarskis EJ, Mendiondo MS, Matthews DE, ALS Nutrition/NIPPV Study Group et al (2014) Estimating daily energy expenditure in individuals with amyotrophic lateral sclerosis. Am J Clin Nutr 99(4):792–803
Kleiner SM (1999) Water: an essential but overlooked nutrient. J Am Diet Assoc 99(2):200–206
Lavizzo-Mourey R, Johnson J, Stolley P (1988) Risk factors for dehydration among elderly nursing home residents. J Am Geriatr Soc 36(3):213–218
Lechtzin N, Wiener CM, Clawson L et al (2001) Hospitalization in amyotrophic lateral sclerosis: causes, costs, and outcomes. Neurology 56(6):753–757
Lesser GT, Markofsky JULES (1979) Body water compartments with human aging using fat-free mass as the reference standard. Am J Physiol Regul Integr Comp Physiol 236(3):R215–R220
Li TM, Alberman E, Swash M (1990) Clinical features and associations of 560 cases of motor neuron disease. J Neurol Neurosurg Psychiatry 53(12):1043–1045
Mentes J (2006) A typology of oral hydration: problems exhibited by frail nursing home residents. J Gerontol Nurs 32(1):13–19
Nicolaidis S (1998) Physiology of thirst. In: Arnaud MJ (ed) Hydration throughout life. John Libbey Eurotext, Montrouge, p 247
Phillips PA, Rolls BJ, Ledingham JG et al (1984) Reduced thirst after water deprivation in healthy elderly men. New Engl J Med 311(12):753–759
Phillips PA, Johnston CI, Gray L (1993) Disturbed fluid and electrolyte homoeostasis following dehydration in elderly people. Age Ageing 22(1):S26–S33
Raman A, Schoeller DA, Subar AF et al (2004) Water turnover in 458 American adults 40–79 yr of age. Am J Physiol Renal Physiol 286(2):F394–F401
Recommended Daily Allowances (1989) Subcommittee on the Tenth Edition of the Recommended Daily Allowances. Food and Nutrition Board, Commission on Life Sciences, National Research Council
Scagnelli CN, Howard DB, Bromberg MB et al (2017) Hydration measured by doubly labeled water in ALS and its effect on survival. ALS Frontotemporal Degeneration 19(3-4):220–231
Silver AJ, Morley JE (1992) Role of the opioid system in the hypodipsia associated with aging. J Am Geriatr Soc 40(6):556–560
van Marken Lichtenbelt WD, Westerterp KR, Wouters L, Luijendijk SC (1994) Validation of bioelectrical impedance measurements as a method to estimate body-water compartments. Am J Clin Nutr 60(2):159–166
Warren JL, Bacon WE, Harris T et al (1994) The burden and outcomes associated with dehydration among US elderly, 1991. Am J Public Health 84(8):1265–1269
Warren JL, Harris T, Phillips C (1996) Dehydration in older adults. JAMA 275(12):912
Weitzman RE, Kleeman CR (1999) The clinical physiology of water metabolism. Part I: the physiologic regulation of arginine vasopressin secretion and thirst. West J Med 131(5):373–400
Zizza CA, Ellison KJ, Wernette CM (2009) Total water intakes of community-living middle-old and oldest-old adults. J Gerontol Ser A Biol Sci Med Sci 64(4):481–486
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Switzerland AG
About this entry
Cite this entry
Scagnelli, C., Waheed, W., Tandan, R. (2019). Hydration in Amyotrophic Lateral Sclerosis. In: Preedy, V., Patel, V. (eds) Handbook of Famine, Starvation, and Nutrient Deprivation. Springer, Cham. https://doi.org/10.1007/978-3-319-40007-5_108-1
Download citation
DOI: https://doi.org/10.1007/978-3-319-40007-5_108-1
Received:
Accepted:
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-40007-5
Online ISBN: 978-3-319-40007-5
eBook Packages: Springer Reference MedicineReference Module Medicine