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Endocrine Cytology

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Pitfalls in Diagnostic Cytopathology With Key Differentiating Cytologic Features

Part of the book series: Essentials in Cytopathology ((EICP,volume 27))

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Abstract

The human endocrine system is extensive, encompasses many organs, and overlaps with many other physiological systems, such as the gastrointestinal and the reproductive ones. Strictly speaking, any organ capable of affecting other organs’ activities by directly secreting hormones into the circulatory system belong to the endocrine system. However, the major endocrine glands include the pineal gland, hypothalamus, pituitary gland, thyroid gland, parathyroid gland, adrenal glands, ovaries, and testes. Of these major organs, cytological specimens are commonly collected from the thyroid gland. Occasionally, lesions from the parathyroid, adrenal glands and ovaries are cytologically sampled. Thus, in this chapter, the focus will be mainly on the thyroid, and briefly on the parathyroid gland, the adrenal glands and the ovaries. Each of these organs is susceptible to non-neoplastic conditions with cytomorphological findings that have been described in neoplastic states in these organs. There are; however, key clinical, radiologic and cytologic aspects that can make such distinction possible.

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Suggested Readings

  1. Absher KJ, Truong LD, Khurana KK, et al. Parathyroid cytology: avoiding diagnostic pitfalls. Head Neck. 2002;24(2):157–64.

    Article  PubMed  Google Scholar 

  2. Allias F, Chanoz J, Blache G, et al. Value of ultrasound-guided fine-needle aspiration in the management of ovarian and paraovarian cysts. Diagn Cytopathol. 2000;22(2):70–80.

    Article  CAS  PubMed  Google Scholar 

  3. Baloch ZW, LiVolsi VA. Post fine-needle aspiration histologic alterations of thyroid revisited. Am J Clin Pathol. 1999;112(3):311–6.

    Article  CAS  PubMed  Google Scholar 

  4. Calderaro J, Andreiuolo F, Baudin E, et al. Fine needle aspiration cytology of oxyphilic parathyroid hyperplasia. Cytopathology. 2010;21(2):135–6.

    Article  CAS  PubMed  Google Scholar 

  5. Carcangiu ML, Steeper T, Zampi G, et al. Anaplastic thyroid carcinoma. A study of 70 cases. Am J Clin Pathol. 1985;83(2):135–58.

    Article  CAS  PubMed  Google Scholar 

  6. Centeno BA, Szyfelbein WM, Daniels GH, et al. Fine needle aspiration biopsy of the thyroid gland in patients with prior Graves’ disease treated with radioactive iodine. Morphologic findings and potential pitfalls. Acta Cytol. 1996;40(6):1189–97.

    Article  CAS  PubMed  Google Scholar 

  7. Chen HI, Akpolat I, Mody DR, et al. Restricted kappa/lambda light chain ratio by flow cytometry in germinal center B cells in Hashimoto thyroiditis. Am J Clin Pathol. 2006;125(1):42–8.

    Article  PubMed  Google Scholar 

  8. Chen KT. Extraneous cells of hepatic origin in adrenal fine needle aspiration as a diagnostic pitfall: a case report. Acta Cytol. 2005;49(4):449–51.

    Article  PubMed  Google Scholar 

  9. Cibas ES, Alexander EK, Benson CB, et al. Indications for thyroid FNA and pre-FNA requirements: a synopsis of the National Cancer Institute Thyroid Fine-Needle Aspiration State of the Science Conference. Diagn Cytopathol. 2008;36(6):390–9.

    Article  PubMed  Google Scholar 

  10. Cibas ES, Ducatman BS. Cytology: diagnostic principles and clinical correlates. 4th ed. Philadelphia, PA: Elsevier/Saunders; 2014.

    Google Scholar 

  11. Demay RM. The art and science of cytopathology. 2nd ed. Chicago, IL: ASCP Press; 2011.

    Google Scholar 

  12. de Agustín P, López-Ríos F, Alberti N, et al. Fine-needle aspiration biopsy of the adrenal glands: a ten-year experience. Diagn Cytopathol. 1999;21(2):92–7.

    Article  PubMed  Google Scholar 

  13. Derringer GA, Thompson LD, Frommelt RA, et al. Malignant lymphoma of the thyroid gland: a clinicopathologic study of 108 cases. Am J Surg Pathol. 2000;24(5):623–39.

    Article  CAS  PubMed  Google Scholar 

  14. Ezzat S, Sarti DA, Cain DR, et al. Thyroid incidentalomas. Prevalence by palpation and ultrasonography. Arch Intern Med. 1994;154(16):1838–40.

    Article  CAS  PubMed  Google Scholar 

  15. Faquin WC, Cibas ES, Renshaw AA. “Atypical” cells in fine-needle aspiration biopsy specimens of benign thyroid cysts. Cancer. 2005;105(2):71–9.

    Article  PubMed  Google Scholar 

  16. Ganjei P, Dickinson B, Harrison T, et al. Aspiration cytology of neoplastic and non-neoplastic ovarian cysts: is it accurate? Int J Gynecol Pathol. 1996;15(2):94–101.

    Article  CAS  PubMed  Google Scholar 

  17. Gonzalez JL, Wang HH, Ducatman BS. Fine-needle aspiration of Hürthle cell lesions. A cytomorphologic approach to diagnosis. Am J Clin Pathol. 1993;100(3):231–5.

    Article  CAS  PubMed  Google Scholar 

  18. Gordon DL, Gattuso P, Castelli M, et al. Effect of fine needle aspiration biopsy on the histology of thyroid neoplasms. Acta Cytol. 1993;37(5):651–4.

    CAS  PubMed  Google Scholar 

  19. Hamberger B, Gharib H, Melton LJ, et al. Fine-needle aspiration biopsy of thyroid nodules. Impact on thyroid practice and cost of care. Am J Med. 1982;73(3):381–4.

    Article  CAS  PubMed  Google Scholar 

  20. Harach HR, Zusman SB, Saravia Day E. Nodular goiter: a histo-cytological study with some emphasis on pitfalls of fine-needle aspiration cytology. Diagn Cytopathol. 1992;8(4):409–19.

    Article  CAS  PubMed  Google Scholar 

  21. Harigopal M, Sahoo S, Recant WM, et al. Fine-needle aspiration of Riedel’s disease: report of a case and review of the literature. Diagn Cytopathol. 2004;30(3):193–7.

    Article  PubMed  Google Scholar 

  22. Hoda RS. Non-gynecologic cytology on liquid-based preparations: a morphologic review of facts and artifacts. Diagn Cytopathol. 2007;35(10):621–34.

    Article  PubMed  Google Scholar 

  23. Keyhani-Rofagha S, Kooner DS, Landas SK, et al. Black thyroid: a pitfall for aspiration cytology. Diagn Cytopathol. 1991;7(6):640–3.

    Article  CAS  PubMed  Google Scholar 

  24. Kuma S, Hirokawa M, Miyauchi A, et al. Cytologic features of hyalinizing trabecular adenoma of the thyroid. Acta Cytol. 2003;47(3):399–404.

    Article  PubMed  Google Scholar 

  25. McCorkell SJ, Niles NL. Fine-needle aspiration of catecholamine-producing adrenal masses: a possibly fatal mistake. AJR Am J Roentgenol. 1985;145(1):113–4.

    Article  CAS  PubMed  Google Scholar 

  26. Moran O, Menczer J, Ben-Baruch G, et al. Cytologic examination of ovarian cyst fluid for the distinction between benign and malignant tumors. Obstet Gynecol. 1993;82(3):444–6.

    CAS  PubMed  Google Scholar 

  27. Lal A, Bourtsos EP, Nayar R, et al. Cytologic features of granulosa cell tumors in fluids and fine needle aspiration specimens. Acta Cytol. 2004;48(3):315–20.

    Article  PubMed  Google Scholar 

  28. Mulvany NJ. Aspiration cytology of ovarian cysts and cystic neoplasms. A study of 235 aspirates. Acta Cytol. 1996;40(5):911–20.

    Article  CAS  PubMed  Google Scholar 

  29. Nassar A, Gupta P, LiVolsi VA, et al. Histiocytic aggregates in benign nodular goiters mimicking cytologic features of papillary thyroid carcinoma (PTC). Diagn Cytopathol. 2003;29(5):243–5.

    Article  PubMed  Google Scholar 

  30. Odashiro AN, Nguyen GK. Fine-needle aspiration cytology of an intrathyroid parathyroid adenoma. Diagn Cytopathol. 2006;34(11):790–2.

    Article  PubMed  Google Scholar 

  31. Odronic SI, Reynolds JP, Chute DJ. Cytologic features of parathyroid fine-needle aspiration on ThinPrep preparations. Cancer Cytopathol. 2014;122(9):678–84.

    Article  PubMed  Google Scholar 

  32. Nguyen GK, Akin MR. Cytopathology of insular carcinoma of the thyroid. Diagn Cytopathol. 2001;25(5):325–30.

    Article  CAS  PubMed  Google Scholar 

  33. Nuñez C, Diaz JI. Ovarian follicular cysts: a potential source of false positive diagnoses in ovarian cytology. Diagn Cytopathol. 1992;8(5):532–6. Discussion 536–537.

    Article  PubMed  Google Scholar 

  34. Rossi ED, Revelli L, Giustozzi E, et al. Large non-functioning parathyroid cysts: our institutional experience of a rare entity and a possible pitfall in thyroid cytology. Cytopathology. 2015;26(2):114–21.

    Article  CAS  PubMed  Google Scholar 

  35. Saxena A, Alport EC, Moshynska O, et al. Clonal B cell populations in a minority of patients with Hashimoto’s thyroiditis. J Clin Pathol. 2004;57(12):1258–63.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Selvaggi SM. Cytology of nonneoplastic cysts of the ovary. Diagn Cytopathol. 1990;6(2):77–85.

    Article  CAS  PubMed  Google Scholar 

  37. Shabb NS, Salti I. Subacute thyroiditis: fine-needle aspiration cytology of 14 cases presenting with thyroid nodules. Diagn Cytopathol. 2006;34(1):18–23.

    Article  PubMed  Google Scholar 

  38. Smejkal V, Smejkalová E, Rosa M, et al. Cytologic changes simulating malignancy in thyrotoxic goiters treated with carbimazole. Acta Cytol. 1985;29(2):173–8.

    CAS  PubMed  Google Scholar 

  39. Stanley MW, Horwitz CA, Frable WJ. Cellular follicular cyst of the ovary: fluid cytology mimicking malignancy. Diagn Cytopathol. 1991;7(1):48–52.

    Article  CAS  PubMed  Google Scholar 

  40. Suen KC. How does one separate cellular follicular lesions of the thyroid by fine-needle aspiration biopsy? Diagn Cytopathol. 1988;4(1):78–81.

    Article  CAS  PubMed  Google Scholar 

  41. Tabbara SO, Acoury N, Sidawy MK. Multinucleated giant cells in thyroid neoplasms. A cytologic, histologic and immunohistochemical study. Acta Cytol. 1996;40(6):1184–8.

    Article  CAS  PubMed  Google Scholar 

  42. Trimbos JB, Hacker NF. The case against aspirating ovarian cysts. Cancer. 1993;72(3):828–31.

    Article  CAS  PubMed  Google Scholar 

  43. Tulecke MA, Wang HH. ThinPrep for cytologic evaluation of follicular thyroid lesions: correlation with histologic findings. Diagn Cytopathol. 2004;30(1):7–13.

    Article  PubMed  Google Scholar 

  44. Us-Krasovec M, Auersperg M, Bergant D, et al. Medullary carcinoma of the thyroid gland: diagnostic cytopathological characteristics. Pathologica. 1998;90(1):5–13.

    CAS  PubMed  Google Scholar 

  45. Yang J, Schnadig V, Logrono R, et al. Fine-needle aspiration of thyroid nodules: a study of 4703 patients with histologic and clinical correlations. Cancer. 2007;111(5):306–15.

    Article  PubMed  Google Scholar 

  46. Wojcik EM, Selvaggi SM. Fine-needle aspiration cytology of cystic ovarian lesions. Diagn Cytopathol. 1994;11(1):9–14.

    Article  CAS  PubMed  Google Scholar 

  47. Wu HH, Cramer HM, Kho J, et al. Fine needle aspiration cytology of benign adrenal cortical nodules. A comparison of cytologic findings with those of primary and metastatic adrenal malignancies. Acta Cytol. 1998;42(6):1352–8.

    Article  CAS  PubMed  Google Scholar 

  48. Yee H, Greenebaum E, Lerner J, et al. Transvaginal sonographic characterization combined with cytologic evaluation in the diagnosis of ovarian and adnexal cysts. Diagn Cytopathol. 1994;10(2):107–12.

    Article  CAS  PubMed  Google Scholar 

  49. Young RH. New and unusual aspects of ovarian germ cell tumors. Am J Surg Pathol. 1993;17(12):1210–24.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology Health Sciences Center, University of New Mexico, Albuquerque, NM, USA

    Von G. Samedi & Thèrése Bocklage

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  1. Von G. Samedi
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  2. Thèrése Bocklage
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Samedi, V.G., Bocklage, T. (2016). Endocrine Cytology. In: Pitfalls in Diagnostic Cytopathology With Key Differentiating Cytologic Features. Essentials in Cytopathology, vol 27. Springer, Cham. https://doi.org/10.1007/978-3-319-39809-9_9

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  • DOI: https://doi.org/10.1007/978-3-319-39809-9_9

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-39807-5

  • Online ISBN: 978-3-319-39809-9

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