Abstract
Childhood ALL (cALL), the most common form of childhood cancer, is curable with ~90% becoming long term survivors using contemporary multi-agent chemotherapy. But there is a great disparity in treatment outcome; this high success rate is limited to high income countries (HIC) with little improvements in low middle income countries (LMIC) over the last 50 years. This inequity is all the more unfortunate because cALL is curable with cheap generic drugs using an appropriately designed treatment protocol, good diagnostic and supportive care, and socio-economic support for the family. Even in the most deprived settings, 30% of cALL can be cured.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Rodriguez-Galindo C, Friedrich P, Alcasabas P, et al. Toward the cure of all children with Cancer through collaborative efforts: pediatric oncology as a global challenge. J Clin Oncol. 2015;33:3065–73.
https://datahelpdesk.worldbank.org/knowledgebase/articles/906519-world-bank-country-and-lending-groups. Accessed 17 Aug 2016.
Yeoh AE, Tan D, Li CK, et al. Management of adult and paediatric acute lymphoblastic leukaemia in Asia: resource-stratified guidelines from the Asian Oncology Summit 2013. Lancet Oncol. 2013;14:e508–23.
Widjajanto PH, Sumadiono S, Cloos J, et al. Randomized double blind trial of ciprofloxacin prophylaxis during induction treatment in childhood acute lymphoblastic leukemia in the WK-ALL protocol in Indonesia. J Blood Med. 2013;4:1–9.
Widjajanto PH, Sumadiono S, Purwanto I, Sutaryo S, Veerman AJ. L-asparaginase: long-term results of a randomized trial of the effect of additional 3 doses during consolidation treatment in the Indonesian WK-ALL-2000 protocol. J Pediatr Hematol Oncol. 2013;35:597–602.
Tubergen DG, Gilchrist GS, O'Brien RT, Coccia PF, Sather HN, Waskerwitz MJ, Hammond GD. Improved outcome with delayed intensification for children with acute lymphoblastic leukemia and intermediate presenting features: a Childrens Cancer Group phase III trial. J Clin Oncol. 1993;11:527–37.
Friedrich P, Lam CG, Itriago E, Perez R, Ribeiro RC, Arora RS. Magnitude of treatment abandonment in childhood cancer. PLoS One. 2015;10:e0135230.
http://www.stjudechild.org/. Accessed 17 Aug 2016.
Brown AE, Asturias EJ, Melgar M, Antillon-Klussmann FA, Mettler P, Levin MJ. Incidence and consequences of varicella in children treated for cancer in Guatemala. World J Pediatr. 2016;12:320–6.
Patel SR, Bate J, Maple PA, Brown K, Breuer J, Heath PT. Varicella zoster immune status in children treated for acute leukemia. Pediatr Blood Cancer. 2014;61:2077–9.
Bate J, Chisholm J, Skinner R, Breuer J, Ramsay M, Wheatley K, Hambleton S, Heath PT. PEPtalk: postexposure prophylaxis against varicella in children with cancer. Arch Dis Child. 2012;97:853–4.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2017 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Yeoh, A. (2017). Developing World Perspective. In: Vora, A. (eds) Childhood Acute Lymphoblastic Leukemia. Springer, Cham. https://doi.org/10.1007/978-3-319-39708-5_13
Download citation
DOI: https://doi.org/10.1007/978-3-319-39708-5_13
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-39707-8
Online ISBN: 978-3-319-39708-5
eBook Packages: MedicineMedicine (R0)