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The Diversification of eIF4E Family Members in Plants and Their Role in the Plant-Virus Interaction

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Book cover Evolution of the Protein Synthesis Machinery and Its Regulation

Abstract

Recruitment of eukaryotic mRNAs by the translation machinery requires binding of their 5′ end (cap) to eIF4E in complex with the bridge protein eIF4G (eIF4F). Plant eIF(iso)4E and eIF(iso)4G form the eIF(iso)4F complex, distinct from eIF4F (formed by eIF4E and eIF4G). Separate eIF(iso)4E and eIF4E clades are detected upon seed plants’ arrival in evolution, while eIF(iso)4G has been present since green algae. Strong preference is observed between eIF(iso)4G and eIF(iso)4E, as well as between eIF4E and eIF4G in vitro and in vivo, suggesting that these complexes exert functionally distinct roles in seed plants. However, the regulatory mechanisms underlying their role in translation or other cellular processes remain mainly unknown, with the notable exception of plant-virus interaction. Individual isoforms are required in a specific way for successful virus infection in a range of plant species. The isolation of resistance-associated mutations in eIF4E family members pinpointed their role through direct interaction with the viral genome-linked protein VPg. In this chapter we review recent research on eIF4E diversification with emphasis on their cellular function and roles in the specificity of plant-virus interaction.

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Acknowledgments

Research performed in Dr. Dinkova’s laboratory is supported by grants from Consejo Nacional de Ciencia y Tecnología, CONACYT 238439, Facultad de Química PAIP 5000-9118, and Programa de Apoyo a Proyectos de Investigación e Innovación Tecnológica, PAPIIT IN211215. The authors acknowledge the help provided by Dr. Vasti T. Juárez-González in figure preparation.

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  1. Departamento Bioquímica, Facultad de Química, Universidad Nacional Autónoma de México, 04510, Mexico City, Mexico

    Tzvetanka D. Dinkova, León Martinez-Castilla & Miguel A. Cruz-Espíndola

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  1. Tzvetanka D. Dinkova
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  2. León Martinez-Castilla
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  3. Miguel A. Cruz-Espíndola
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Correspondence to Tzvetanka D. Dinkova .

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  1. Division of Basic Research, National Institute for Cancer, Mexico City, Distrito Federal, Mexico

    Greco Hernández

  2. Institute of Marine and Environmental Te, Univ. of Maryland Center for Environment, Baltimore, Maryland, USA

    Rosemary Jagus

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Dinkova, T.D., Martinez-Castilla, L., Cruz-Espíndola, M.A. (2016). The Diversification of eIF4E Family Members in Plants and Their Role in the Plant-Virus Interaction. In: Hernández, G., Jagus, R. (eds) Evolution of the Protein Synthesis Machinery and Its Regulation. Springer, Cham. https://doi.org/10.1007/978-3-319-39468-8_9

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