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Dynamic and Active Proteins: Biomolecular Motors in Engineered Nanostructures

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Protein-based Engineered Nanostructures

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 940))

Abstract

In Nature, proteins perform functions that go well beyond controlled self-assembly at the nano scale. They are the principal components of diverse “biological machines” that can self-assemble into dynamic aggregates that achieve the cold conversion of chemical energy into motion to realize complex functions involved in cell division, cellular transport and cell motility. Nowadays, we have identified many of the proteins involved in these “molecular machines” and know much about their biochemistry, structure and biophysical behavior. Additionally, we have a rich toolbox of resources to engineer the basic dynamic working units into nanostructures to provide them with motion and the capacity to manipulate, transport, separate or sense single molecules to develop in vitro sensors and bioassays. This chapter summarizes some of the progress made in incorporating bio-molecular motors and dynamic self-organizing proteins into protein based functional nanostructures.

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  1. Instituto de Catálisis y Petroleoquímica, CSIC, c/ Marie Curie 2, 28049, Cantoblanco, Madrid, Spain

    Marisela Vélez

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  1. CIC BiomaGUNE, Donostia-San Sebastián, Spain

    Aitziber L. Cortajarena

  2. Department of Chemistry, Virginia Tech, Blacksburg, Virginia, USA

    Tijana Z. Grove

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Vélez, M. (2016). Dynamic and Active Proteins: Biomolecular Motors in Engineered Nanostructures. In: Cortajarena, A., Grove, T. (eds) Protein-based Engineered Nanostructures. Advances in Experimental Medicine and Biology, vol 940. Springer, Cham. https://doi.org/10.1007/978-3-319-39196-0_6

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