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Bionanomaterials with Antioxidant Effect for Skin Regeneration

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Bionanomaterials for Skin Regeneration

Part of the book series: SpringerBriefs in Bioengineering ((BRIEFSBIOENG))

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Abstract

Oxidative processes are an important path to degradation for many materials. Usually oxidative stress is the term used to describe the effect of this type of reactions on biosystems. Skin, as the largest organ in the body, is understandably an important target for oxidative stress leading to aging of the skin, to skin disorders, and skin disease. The balance between the rate of renewal (growth) and the rate of degradation is what imparts the general look to the skin. Aging translates into decrease in resistance to stress of any type together with decrease in function. Besides these intrinsic factors common to all unavoidable aging processes, in the case of skin there is influence from extrinsic (environmental) factors such as sun exposure and UV radiation (responsible for photoaging—the superimposition of damage produced by light on the aging process), whose action can be prevented/limited [1]. There is a difference in how these types of factors work. While physiological aging of the skin results in a slow decline in skin’s defense mechanisms, UV irradiation accelerates skin aging and may also induce inflammation which may result in accelerated breakdown of collagen and hyperproliferative processes in the epidermis. When, more recently, peroxidation was highlighted as involved in aging and cancer it became generally accepted that reactive oxygen species (ROS) and free radicals have an important role in skin aging [2] and disease and that UV exposure can lead to DNA damage (see Chap. 2) hence malignancies [3].

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Authors and Affiliations

  1. Fairleigh Dickinson University, Teaneck, NJ, USA

    Mihaela D. Leonida & Ish Kumar

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  1. Mihaela D. Leonida
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  2. Ish Kumar
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Leonida, M.D., Kumar, I. (2016). Bionanomaterials with Antioxidant Effect for Skin Regeneration. In: Bionanomaterials for Skin Regeneration. SpringerBriefs in Bioengineering. Springer, Cham. https://doi.org/10.1007/978-3-319-39168-7_8

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  • DOI: https://doi.org/10.1007/978-3-319-39168-7_8

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-39166-3

  • Online ISBN: 978-3-319-39168-7

  • eBook Packages: EngineeringEngineering (R0)

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