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Design of a Compact, Bimorph Deformable Mirror-Based Adaptive Optics Scanning Laser Ophthalmoscope

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Oxygen Transport to Tissue XXXVIII

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 923))

Abstract

We have designed, constructed and tested an adaptive optics scanning laser ophthalmoscope (AOSLO) using a bimorph mirror. The simulated AOSLO system achieves diffraction-limited criterion through all the raster scanning fields (6.4 mm pupil, 3° × 3° on pupil). The bimorph mirror-based AOSLO corrected ocular aberrations in model eyes to less than 0.1 μm RMS wavefront error with a closed-loop bandwidth of a few Hz. Facilitated with a bimorph mirror at a stroke of ±15 μm with 35 elements and an aperture of 20 mm, the new AOSLO system has a size only half that of the first-generation AOSLO system. The significant increase in stroke allows for large ocular aberrations such as defocus in the range of ±600° and astigmatism in the range of ±200°, thereby fully exploiting the AO correcting capabilities for diseased human eyes in the future.

These authors contributed to the work equllly and should be considered co-first authors.

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Acknowledgments

This work is supported by the Outstanding Young Scientists of the Chinese Academy of Sciences, the National Instrumentation Program (NIP, Grant No. 2012YQ120080), the Zhejiang Province Technology Program (Grant No. 2013C33170), the National Science Foundation of China (Grant No. 61108082), the Sichuan Youth Science & Technology Foundation (Grant No. 2013JQ0028) and the West Light Foundation of the Chinese Academy of Sciences. The authors would like to thank Hao Li and Jing Lu for many helpful discussions regarding this project.

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    Authors and Affiliations

    1. The Key Laboratory on Adaptive Optics, Chinese Academy of Sciences, Chengdu, 610209, China

      Yi He, Ling Wei, Xiqi Li, Jinsheng Yang, Guohua Shi & Yudong Zhang

    2. The Laboratory on Adaptive Optics, Institute of Optics and Electronics, Chinese Academy of Sciences, Chengdu, 610209, China

      Yi He, Ling Wei, Xiqi Li, Jinsheng Yang, Guohua Shi & Yudong Zhang

    3. Department of Ophthalmology, The Third People’s Hospital of Changzhou, Changzhou, Jiangsu, China

      Guohua Deng

    Authors
    1. Yi He
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    2. Guohua Deng
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    3. Ling Wei
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    4. Xiqi Li
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    5. Jinsheng Yang
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    6. Guohua Shi
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    7. Yudong Zhang
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    Corresponding authors

    Correspondence to Yi He or Guohua Shi .

    Editor information

    Editors and Affiliations

    1. Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, China

      Qingming Luo

    2. Molecular Imaging Laboratory, Department of Radiology, Britton Chance Laboratory of Redox Imaging, Johnson Research Foundation, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

      Lin Z. Li

    3. Microvascular Measurements, St. Lorenzen, Italy

      David K. Harrison

    4. Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, China

      Hua Shi

    5. ISOTT Historian, Ellicott City, Maryland, USA

      Duane F. Bruley

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    © 2016 Springer International Publishing Switzerland

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    He, Y. et al. (2016). Design of a Compact, Bimorph Deformable Mirror-Based Adaptive Optics Scanning Laser Ophthalmoscope. In: Luo, Q., Li, L., Harrison, D., Shi, H., Bruley, D. (eds) Oxygen Transport to Tissue XXXVIII. Advances in Experimental Medicine and Biology, vol 923. Springer, Cham. https://doi.org/10.1007/978-3-319-38810-6_49

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