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Nodular Hyperplasia of Thyroid, Cytological Findings

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Cytopathology

Part of the book series: Encyclopedia of Pathology ((EP))

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Synonyms

Adenomatous/adenomatoïd nodule; Hyperplastic nodule; Multinodular goiter

Definition

The term “goiter” refers to any enlargement of the thyroid gland and is considered as a non-neoplastic process, usually benign, essentially due to iodine deficiency, but sometimes of unknown etiology. The term “goiter” includes both either a thyroid gland deformed by numerous nodules of varying sizes or a diffuse enlargement of the gland. The nodular goiters are histologically represented by two different types of nodules: the colloid nodules, related with accumulation of the colloid within the follicles and the hyperplastic (adenomatoid) nodules, characterized by a hyperplasia of the follicular cells.

Clinical Features

  • Incidence

    Nodular goiters represent one of the most frequent diseases in the world with a prevalence from 1% to 10%, depending on geographic locations. Goiters are more frequent in mountains than in the low lands and on the sea-side. In the United States, there is an estimated...

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References and Further Reading

  • Ali, S. Z., & Cibas, E. S. (2009). The Bethesda system for reporting thyroid cytopathology. Definitions, criteria and explanatory notes. New York: Springer.

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  • Brito, J. P., Yarur, A. J., Prokop, L. J., McIver, B., Murad, M. H., & Montori, V. M. (2013). Prevalence of thyroid cancer in multinodular goiter versus single nodule: A systematic review and meta-analysis prevalence. Thyroid, 23, 449–455.

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  • Cochand-Priollet, B., Dahan, H., Laloi-Michelin, M., Polivka, M., Saada, M., Herman, P., et al. (2011). Immunocytochemistry with Cytokeratin 19 and anti-human mesothelial cell antibody (HBME1) increases the diagnostic accuracy of thyroid fine-needle aspirations: Preliminary report of 150 liquid-based fine-needle aspirations with histological control. Thyroid, 21, 1067–1073.

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  • Marotta, V., Guerra, A., Sapio, M. R., Campanile, E., Motta, M., Fenzi, G., et al. (2010). Growing thyroid nodules with benign histology and RET arrangement. Endocrine Journal, 57, 1081–1087.

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Author information

Authors and Affiliations

  1. Department of Pathology, Cochin Hospital, University Paris 5, Paris, France

    Beatrix Cochand-Priollet

Authors
  1. Beatrix Cochand-Priollet
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Corresponding author

Correspondence to Beatrix Cochand-Priollet .

Editor information

Editors and Affiliations

  1. Laboratoire national de santé, Luxembourg City, Luxembourg

    Fernando Schmitt

  2. Medical Faculty of Porto University and IPATIMUP, Porto, Portugal

    Fernando Schmitt

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Cochand-Priollet, B. (2017). Nodular Hyperplasia of Thyroid, Cytological Findings. In: Schmitt, F. (eds) Cytopathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-33286-4_940

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  • DOI: https://doi.org/10.1007/978-3-319-33286-4_940

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-33285-7

  • Online ISBN: 978-3-319-33286-4

  • eBook Packages: MedicineReference Module Medicine

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