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Carcinoma ex Pleomorphic Adenoma, Cytological Findings

  • Reference work entry
  • First Online:
Cytopathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 58 Accesses

Synonyms

Malignant mixed tumor (not appropriate: see differential diagnosis)

Definition

Carcinoma ex pleomorphic adenoma (CEPA) is a carcinoma which arises from epithelial cells in pleomorphic adenoma (Barnes et al. 2005; Ellis and Auclair 2008). Clinically, CEPA presents in two forms: de novo or recurrent with in situ or infiltrative pattern. The clinical data and previous history of salivary (lacrimal) tumor are important in the diagnostic process.

Although CEPA belongs to high-grade malignancy, clinical prognosis depends on histological type of carcinoma arising in pleomorphic adenoma.

Clinical Features

  • Incidence

    CEPA is a relatively common malignancy and represent approximately 2% of all salivary gland lesions and more than 6% of salivary gland carcinomas. It develops 12 years in average after a diagnosis of underlying pleomorphic adenoma.

  • Age

    CEPA occurs at any age, but its peak of incidence is in the sixth and eighth decades of life.

  • Sex

    There is a slight female-to-male...

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References and Further Reading

  • Anand, A., & Brockie, E. S. (1999). Cytomorphological features of salivary duct carcinoma ex pleomorphic adenoma: Diagnosis by fine-needle aspiration biopsy with histologic correlation. Diagnostic Cytopathology, 20, 375–378.

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  • Antony, J., Gopalan, V., Smith, R. A., & Lam, A. K. (2012). Carcinoma ex pleomorphic adenoma: A comprehensive review of clinical, pathological and molecular data. Head and Neck Pathology, 6, 1–9.

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  • Barnes, L., Eveson, J. W., Reichert, P., & Sidransky, D. (Eds.). (2005). World Health Organization classification of tumours. Pathology and genetics of head and neck tumours. Lyon: IARC Press.

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  • Ellis, G. L., & Auclair, P. L. (2008). Tumors of the salivary glands. AFIP atlas of tumor pathology. Fourth series, Fascicle 9. Washington, DC: American Registry of Pathology, ARP Press.

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  • El-Naggar, A. K., Callender, D., Coombes, M. M., Hurr, K., Luna, M. A., & Batsakis, J. G. (2000). Molecular genetic alterations in carcinoma ex-pleomorphic adenoma: A putative progression model? Genes, Chromosomes & Cancer, 27, 162–168.

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  • Ersöz, C., Cetik, F., Aydin, O., Cosar, E. F., & Talas, D. U. (1998). Salivary duct carcinoma ex pleomorphic adenoma: Analysis of the findings in fine-needle aspiration cytology and histology. Diagnostic Cytopathology, 19, 201–204.

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  • Klijanienko, J., El-Naggar, A. K., Servois, V., Rodriguez, J., Validire, P., & Vielh, P. (1998). Mucoepidermoid carcinoma ex pleomorphic adenoma: Nonspecific preoperative cytologic findings in six cases. Cancer, 84, 231–234.

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  • Klijanienko, J., El-Naggar, A. K., & Vielh, P. (1999a). Fine-needle sampling findings in 26 carcinoma ex pleomorphic adenomas: Diagnostic pitfalls and clinical considerations. Diagnostic Cytopathology, 21, 163–166.

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  • Klijanienko, J., El-Naggar, A. K., Servois, V., et al. (1999b). Histologically similar, synchronous or metachronous, lacrimal salivary-type and parotid gland tumors: A series of 11 cases. Head & Neck, 21, 512–516.

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  • Nigam, S., Kumar, N., & Jain, S. (2004). Cytomorphologic spectrum of carcinoma ex pleomorphic adenoma. Acta Cytologica, 48, 309–314.

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Author information

Authors and Affiliations

  1. Institut Curie, 26, rue d’Ulm, 75005, Paris, France

    Jerzy Klijanienko

  2. Department of Biopathology, Gustave Roussy Cancer Campus, 114, rue Edouard Vaillant, 94805, Villejuif, France

    Philippe Vielh

Authors
  1. Jerzy Klijanienko
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  2. Philippe Vielh
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Corresponding author

Correspondence to Jerzy Klijanienko .

Editor information

Editors and Affiliations

  1. Laboratoire national de santé, Luxembourg City, Luxembourg

    Fernando Schmitt

  2. Medical Faculty of Porto University and IPATIMUP, Porto, Portugal

    Fernando Schmitt

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Klijanienko, J., Vielh, P. (2017). Carcinoma ex Pleomorphic Adenoma, Cytological Findings. In: Schmitt, F. (eds) Cytopathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-33286-4_914

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  • DOI: https://doi.org/10.1007/978-3-319-33286-4_914

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-33285-7

  • Online ISBN: 978-3-319-33286-4

  • eBook Packages: MedicineReference Module Medicine

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