Hodgkin Lymphoma, Cytological Findings

Tani, Edneia Miyki; Skoog, Lambert

doi:10.1007/978-3-319-33286-4_896

Edneia Miyki Tani³ &
Lambert Skoog³

Part of the book series: Encyclopedia of Pathology ((EP))

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Synonyms

Hodgkin’s disease; Lymphogranulomatosis

Variants

1.
Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL)
2.
Classical Hodgkin lymphoma (CHL)

Definition

Lymph node disease with few large mono- and binucleated tumor cell mixed with a rich number of non-neoplastic lymphocytes and various inflammatory cells

Clinical Features

Incidence
NLPHL: 0.2/100,000
CHL: 4/100,000
Age
NLPHL: middle aged
CHL: young adults and elderly
Sex
NLPHL: male predominance
CHL: somewhat more common in males than in females.
Site
NLPHL: cervical, axillary, and inguinal nodes.
CHL: cervical, mediastinal, and axillary nodes.
Extranodal dissemination is rare in both subtypes.
Treatment
Chemotherapy, radiation
Outcome
NLPHL: patients with low stage disease have a 10 year survival round 80%.
CHL: Over 80% of patients are cured.

Microscopy

NLPHL: The smears show a large number of predominantly mature lymphoid cells and histiocytes some of which are of epithelioid type. The tumor cells are large with a scant,...

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References and Further Reading

Chhieng, D. C., Cangiarella, J. F., Symmans, W. F., & Cohen, J. M. (2001). Fine-needle aspiration cytology of Hodgkin disease: A study of 89 cases with emphasis on false-negative cases. Cancer, 93, 52–59.
Article CAS PubMed Google Scholar
Das, D. K., & Gupta, S. K. (1990). Fine needle aspiration cytodiagnosis of Hodgkin’s disease and its subtypes. II. Subtyping by differential cell counts. Acta Cytologica, 34, 337–341.
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Fulciniti, F., Vetrani, A., Zeppa, P., Giordano, G., Marino, M., De Rosa, G., & Palombini, L. (1994). Hodgkin’s disease: Diagnostic accuracy of fine needle aspiration; a report based on 62 consecutive cases. Cytopathology, 5, 226–233.
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Jimenez-Heffernan, J. A., Vicandi, B., Lopez-Ferrer, P., Hardisson, D., & Viguer, J. M. (2001). Value of fine needle aspiration cytology in the initial diagnosis of Hodgkin’s disease. Analysis of 188 cases with an emphasis on diagnostic pitfalls. Acta Cytologica, 45, 300–306.
Article CAS PubMed Google Scholar
Moreland, W. S., & Geisinger, K. R. (2002). Utility and outcomes of fine-needle aspiration biopsy in Hodgkin’s disease. Diagnostic Cytopathology, 26, 278–282.
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Author information

Authors and Affiliations

Department of Pathology and Cytology, Karolinka University Hospital, Solna, Stockholm, SE 171 76, Sweden
Edneia Miyki Tani & Lambert Skoog

Authors

Edneia Miyki Tani
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Lambert Skoog
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Corresponding author

Correspondence to Edneia Miyki Tani .

Editor information

Editors and Affiliations

Laboratoire national de santé, Luxembourg City, Luxembourg
Fernando Schmitt
Medical Faculty of Porto University and IPATIMUP, Porto, Portugal
Fernando Schmitt

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Tani, E.M., Skoog, L. (2017). Hodgkin Lymphoma, Cytological Findings. In: Schmitt, F. (eds) Cytopathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-33286-4_896

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DOI: https://doi.org/10.1007/978-3-319-33286-4_896
Published: 31 May 2017
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-33285-7
Online ISBN: 978-3-319-33286-4
eBook Packages: MedicineReference Module Medicine

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