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Fungi Infections, Cytological Findings

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Cytopathology

Part of the book series: Encyclopedia of Pathology ((EP))

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Synonyms

Granulomatous lymphadenitis of fungus etiology

Definition

Fungal infections have significant manifestations in the lymph nodes as a disseminated infection or primary infections spread to local or regional nodes. Most commonly seen in immunosuppressed patients, especially those with HIV/AIDS or post transplantation.

Clinical Features

  • Incidence

    Varies between continent, countries, and regions. Cryptococcus neoformans has a worldwide distribution and is endemic in soil. Blastomyces dermatitidis, Histoplasmosis, and Coccidioides immitis are most often seen in the United States, but cases are also seen in Central and South America. Paracoccidioides brasiliensis is endemic in South and Central America.

  • Age

    All ages can be affected.

  • Sex

    No sex predilection.

  • Site

    Lymph nodes are the most common site but spleen and various parenchymatous organs may also be affected.

  • Treatment

    Fluconazole, itraconazole, ketoconazole, anphotericin B, trimethoprim-sulfamethoxazole, and pentamidine are the...

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References and Further Reading

  • Gerhard, R., & Basso, M. C. (2007). Diagnosis of three cases of paracoccidioidomycosis by fine needle aspiration cytology. Cytopathology, 18, 125–127.

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  • Gupta, N., Arora, S. K., Rajwanshi, A., Nijhawan, R., & Srinivasan, R. (2010). Histoplasmosis: Cytodiagnosis and review of literature with special emphasis on differential diagnosis on cytomorphology. Cytopathology, 21, 240–244.

    Article  CAS  PubMed  Google Scholar 

  • Silva, A. R., Vargas, P. A., Ribeiro, A. C., Martinez-Mata, G., Coletta, R. D., & Lopes, M. A. (2010). Fine needle aspiration cytology in the diagnosis of cervical tuberculosis and paracoccidioidomycosis. Cytopathology, 21, 66–68.

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  • Srinivasan, R., Gupta, N., Shifa, R., Malhotra, P., Rajwanshi, A., & Chakrabarti, A. (2010). Cryptococcal lymphadenitis diagnosed by fine needle aspiration cytology: A review of 15 cases. Acta Cytologica, 54, 1–4.

    Article  PubMed  Google Scholar 

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Correspondence to Edneia Miyki Tani .

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Tani, E.M., Skoog, L. (2017). Fungi Infections, Cytological Findings. In: Schmitt, F. (eds) Cytopathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-33286-4_882

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  • DOI: https://doi.org/10.1007/978-3-319-33286-4_882

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-33285-7

  • Online ISBN: 978-3-319-33286-4

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