Synonyms
Granulomatous lymphadenitis of fungus etiology
Definition
Fungal infections have significant manifestations in the lymph nodes as a disseminated infection or primary infections spread to local or regional nodes. Most commonly seen in immunosuppressed patients, especially those with HIV/AIDS or post transplantation.
Clinical Features
Incidence
Varies between continent, countries, and regions. Cryptococcus neoformans has a worldwide distribution and is endemic in soil. Blastomyces dermatitidis, Histoplasmosis, and Coccidioides immitis are most often seen in the United States, but cases are also seen in Central and South America. Paracoccidioides brasiliensis is endemic in South and Central America.
Age
All ages can be affected.
Sex
No sex predilection.
Site
Lymph nodes are the most common site but spleen and various parenchymatous organs may also be affected.
Treatment
Fluconazole, itraconazole, ketoconazole, anphotericin B, trimethoprim-sulfamethoxazole, and pentamidine are the...
References and Further Reading
Gerhard, R., & Basso, M. C. (2007). Diagnosis of three cases of paracoccidioidomycosis by fine needle aspiration cytology. Cytopathology, 18, 125–127.
Gupta, N., Arora, S. K., Rajwanshi, A., Nijhawan, R., & Srinivasan, R. (2010). Histoplasmosis: Cytodiagnosis and review of literature with special emphasis on differential diagnosis on cytomorphology. Cytopathology, 21, 240–244.
Silva, A. R., Vargas, P. A., Ribeiro, A. C., Martinez-Mata, G., Coletta, R. D., & Lopes, M. A. (2010). Fine needle aspiration cytology in the diagnosis of cervical tuberculosis and paracoccidioidomycosis. Cytopathology, 21, 66–68.
Srinivasan, R., Gupta, N., Shifa, R., Malhotra, P., Rajwanshi, A., & Chakrabarti, A. (2010). Cryptococcal lymphadenitis diagnosed by fine needle aspiration cytology: A review of 15 cases. Acta Cytologica, 54, 1–4.
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Tani, E.M., Skoog, L. (2017). Fungi Infections, Cytological Findings. In: Schmitt, F. (eds) Cytopathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-33286-4_882
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DOI: https://doi.org/10.1007/978-3-319-33286-4_882
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