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Advances in Radiation Therapy

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Pediatric CNS Tumors

Part of the book series: Pediatric Oncology ((PEDIATRICO))

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Abstract

Recent developments in radiation therapy have largely centered on the improvement in delivering radiation to a highly conformal target with high precision. The increased use of stereotactic body radiotherapy (SBRT) has also introduced another dimension of treatment, potentially replacing surgery in select situations to aggressive treatment of oligometastatic disease to invoking a systemic response using immunomodulators. Simultaneously, advances in systemic therapy ranging from traditional chemotherapy regimens to targeted biologics, and more recently immune modulators, are rapidly affecting the field of radiation oncology. These advances rely on a synergy between significant improvements in radiation delivery, driven by image guidances and more conformal delivery or radiation, and a greater understanding of tumor biology. This chapter will focus on an understanding of advances in these areas and future directions for pediatric brain tumors levering these innovations.

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Authors and Affiliations

  1. Department of Radiation Oncology, University of California San Francisco, 1825 4th Street, Room M2260, San Francisco, CA, 94158, USA

    Mekhail Anwar MD, PhD

  2. Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY, 10065, USA

    Sean M. McBride MD, MPH

  3. Department of Radiation Oncology, Brigham and Women’s Hospital, Dana-Farber Cancer Institute, Boston Children’s Hospital, 450 Brookline Ave. D1622, Boston, MA, 02215-5418, USA

    Daphne A. Haas-Kogan MD

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  1. Mekhail Anwar MD, PhD
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Correspondence to Mekhail Anwar MD, PhD .

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  1. San Francisco, California, USA

    Nalin Gupta

  2. San Francisco, California, USA

    Anuradha Banerjee

  3. Boston, Massachusetts, USA

    Daphne A. Haas-Kogan

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Anwar, M., McBride, S.M., Haas-Kogan, D.A. (2017). Advances in Radiation Therapy. In: Gupta, N., Banerjee, A., Haas-Kogan, D. (eds) Pediatric CNS Tumors. Pediatric Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-30789-3_16

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