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Colloidal Carriers in Ophthalmic Drug Delivery

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Nano-Biomaterials For Ophthalmic Drug Delivery

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Abstract

Ocular diseases like cataract, glaucoma, retinoblastoma, diabetic retinopathy, retinal degeneration, retinitis pigmentosa, and choroidal neovascularization are the leading causes of blindness all over the world. Drugs for treating eye diseases are limited in their efficacy due to different ocular barriers. Furthermore, most of the drugs show either poor ocular permeation or rapid clearance from the eyes. The use of colloidal carriers such as nanoparticles, dendrimers, and liposomes has shown the potential to overcome these barriers to the usefulness of a drug. Preclinical and a few clinical studies illustrate that these carrier systems are very useful for delivering wide variety of drugs and genes. These carriers have found applications not only in drug delivery but also in imaging and diagnostics. This chapter focuses on some recent developments in these colloidal systems and discusses how drug delivery to both anterior and posterior eye can be optimized by understanding route of delivery and properties of colloidal systems and their suitability based on drug and disease targeted.

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Authors and Affiliations

  1. Associate Professor of Pharmaceutical Sciences, L|E|C|O|M Bradenton School of Pharmacy, 5000 Lakewood Ranch Blvd, Office#281, Bradenton, 34211, FL, USA

    Deepak Gupta

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  1. Deepak Gupta
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Editors and Affiliations

  1. College of Pharmacy, University of South Florida Health, Tampa, Florida, USA

    Yashwant Pathak

  2. College of Pharmacy, University of South Florida Health, Tampa, Florida, USA

    Vijaykumar Sutariya

  3. College of Pharmacy, University of South Florida, Tampa, Florida, USA

    Anjali A. Hirani

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Gupta, D. (2016). Colloidal Carriers in Ophthalmic Drug Delivery. In: Pathak, Y., Sutariya, V., Hirani, A. (eds) Nano-Biomaterials For Ophthalmic Drug Delivery. Springer, Cham. https://doi.org/10.1007/978-3-319-29346-2_15

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